Sol-gel derived boehmite nanostructures is a versatile nanoplatform for biomedical applications

Abstract

Alumina is one of the most promising carriers for drug delivery due to the long history of its usage as a vaccine adjuvant. Sol-gel synthesis provides excellent conditions for entrapment of biomolecules within an inorganic cage providing stabilization of proteins under the extremal conditions. In this paper, we show in vitro investigation of monodisperse alumina xerogel nanocontainers (AXNCs) using bovine serum albumin as a model protein entrapped in sol-gel alumina building blocks. Particularly, dose and cell-type dependent cytotoxicity in HeLa and A549 cancer cell lines were employed as well as investigation of antibacterial effect and stability of AXNCs in different biological media. It was shown, that the release of entrapped protein could be provided only in low pH buffer (as in cancer cell cytoplasm). This property could be applied for anticancer drug development. We also discovered boehmite nanoparticles effect on horizontal gene transfer and observed the appearance of antibiotic resistance by means of exchanging of the corresponding plasmid between two different E. coli strains. The present work may help to understand better the influence of AXNCs on various biological systems, such as prokaryotic and eukaryotic cells, and the activity of AXNCs in different biological media.

Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations

“…In addition to direct DNA damage under the influence of NPs, there are also data on increasing the efficiency of horizontal transfer of genetic material when exposed to NPs. It has been shown that Al 2 O 3 , AlOOH, TiO 2 , SiO 2 , and Fe 2 O 3 NPs can contribute to the conjugating transfer of plasmid (up to 20–100 times) [ 159 , 160 , 161 ]. It is important to note that the transfer increased inside the species or genus of bacteria.…”

Boehmite@tryptophan‐Pd nanoparticles: A new catalyst for C–C bond formation

“…Among the various supports, boehmite nanoparticles are considered as outstanding solid supports because of their physical and chemical properties such as excellent thermal and chemical stability, large internal surface area and high concentration of surface OH groups. Boehmite nanoparticles have applications in a wide variety of endeavors suchz as: the preparation of sol–gel ceramics, for rheology control, as medicinal desiccants and their carrier, as absorbents, for coatings, in electrochemical sensors, as vaccine adjuvants, in the petrochemical industry and most widely used as catalysts and catalyst carriers . More importantly, the immobilization of transition metal complexes on the nano‐boehmite surface has been rarely reported in the literature for the purpose of synthesizing heterogeneous catalysts …”

Cu(II) and Gd(III) doped boehmite nanostructures: a comparative study of electrical property and thermal stability

“…Some research is based on different properties such as optical [33], electrical [34], mechanical properties [35] of boehmite those are showing its multi-dimensional usability. Biocompatibility is another major advantage of selecting boehmite for any application [36]. Boehmite was reported as a promising dental and orthopedic material due to its biocompatibility and bioavailability [37,38].…”