Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

Abstract

A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400-500 µm, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.

The “Artificial Artery” as In Vitro Perfusion Model

“…We have chosen those materials because they are known to be used clinically and in research [42], [43], [44], [45], [46], [47]. All membranes were provided by Membrana and varied in their physical properties such as wall thickness and maximum pore size ( Table S1 ).…”

Bioactive glass-based materials with hierarchical porosity for medical applications: Review of recent advances

“…The obtained composite scaffolds showed increased mechanical strength up to 1 MPa compared to the pure silk reference material, formation of surface hydroxyapatite after 24 h and a high ALP activity [106]. Su et al used solvent casting and particulate leaching to fabricate MBG/polyamide scaffolds that exhibited excellent biocompatibility and osteoconductivity as well as more effective osteogenesis than the reference polyamide scaffold in vivo [107].…”

3D-printed hierarchical scaffold for localized isoniazid/rifampin drug delivery and osteoarticular tuberculosis therapy

“…For instance, Shi et al and Yun et al reported the preparation of hierarchically MBG scaffolds by using the nonionic triblock copolymer and polyurethane as co-templates to achieve nanoporosity (<10 nm) and macro porosity (>100 lm) respectively, and their compressive modulus was less than 1 MPa [30][31][32]. As a solution, composites of biodegradable polymers (PCL, PLGA, alginate, collagen and so on) and MBG ceramics were developed to increase the mechanical stability [33,34]. In addition, an alternative 3D plotting method is developed to promote mechanical strength [35,36].…”