Bioactive glass-based materials with hierarchical porosity for medical applications: Review of recent advances

Quantifying the micro-architectural similarity of bioceramic scaffolds to bone

“…The processing methods described above have also been combined with supramolecular chemistry to produce hierarchical macro-mesoporous bioactive glass structures [30]. Fig.…”

Synthesis and In Vitro Activity Assessment of Novel Silicon Oxycarbide-Based Bioactive Glasses

“…The co-existence of a crystalline phase and a residual glassy phase affects the mechanical properties of scaffolds; consequently, the processed 45S5 Bioglass ® scaffolds often have low strength [8]. In order to overcome this drawback and to increase the crystallization temperature of BGs, significant efforts have been made with a special focus on developing novel compositions using new synthesis methods such as the sol–gel process [9,10,11,12]. An early extensive investigation of new glass compositions was conducted by Brink and colleagues to identify alternative bioactive glass compositions suitable for use as processed materials such as coatings and scaffolds [13,14].…”

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“…A variety of calcium and ceramic bone graft void fillers have been used to not only promote osseointegration but also as a drug delivery carrier. However, the success of bone graft in osteointegration and antibiotic release can be correlated with the porosity of bone graft substrate [24,25]. Several highly porous CPbased bone void fillers have been shown effective for both in vitro drug release and in vivo infection protection and osseointegration.…”