Comportement electrochimique anodique de divers neuroleptiques en milieu aqueux et non-aqueux

Kauffmann, Jean‐Michel; Patriarche, Gaston; Genies, M.

doi:10.1016/0013-4686(82)85065-2

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…The electrochemical oxidation [17,19] and réduction [18.20] of the molécules have been studied quite extensively. Table 1 contains a summary of the mechanisms proposed.…”

Section: Resultsmentioning

confidence: 99%

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Tentative correlation between the electrochemical oxidation of neuroleptics and their pharmacological properties

Kauffmann¹,

Viré²,

Patriarche³

1984

Bioelectrochemistry and Bioenergetics

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A number of drugs are largely metabolized after oral administration, especially by redox processes. Among the neuroleptics. loxapine. clotiapine and clozapine. which are sevenmembered tricyclic molé cules with a piperazine sidechain. are known to be extensively metabolized by oxidation. An electrochemical study of thèse compounds was initiated in order to détermine their in vitro redox properties and to elucidate their oxidation mechanisms. The measurements were carried out in aqueous and nonaqueous média using voltammetric, cyclic voltammetric, coulometric. exhaustive electrolysis and thinlayer spectroelectrochemical techniques. The oxidation mechanisms, which differ essentially depending on the pH of the solution, are suggested. In view of thèse results, various similarities have been detected between the in vitro oxidation processes and the pharmacological behaviour reported in the literature. For example, the importance of the piperazine sidechain has been pointed out: oxidation no longer occurs if this sidechain is protonated; similarly, binding to the receptor is prevented if the lone électron pair of the tertiary atom is occupied. Nucleophilic additions have aiso been observed in nonaqueous média and the compounds have been identified using classical spectroscopic techniques. If the oxidation mechanism is identical on the piperazine chain for the three compounds. the process is somewhat différent when it occurs on the tricyclic ring. Loxapine and clotiapine exhibit différent behaviour from clozapine, in their electrochemical as well as in their pharmacological properties.

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“…The electrochemical oxidation [17,19] and réduction [18.20] of the molécules have been studied quite extensively. Table 1 contains a summary of the mechanisms proposed.…”

Section: Resultsmentioning

confidence: 99%

“…The equipment for thin-layer spectroelectrochemistry has been described elsewhere [17][18][19][20][21].…”

Section: Ismentioning

confidence: 99%

Tentative correlation between the electrochemical oxidation of neuroleptics and their pharmacological properties

Kauffmann¹,

Viré²,

Patriarche³

1984

Bioelectrochemistry and Bioenergetics

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“…In particular, d 10 metal complexes have attracted much interest in recent years, not only because of their interesting structures but also because of their photoluminescence properties [12,13]. Although there have been several reports on the electrochemical behavior of piperazine molecules [14][15][16][17], study of their anodic oxidation in a coordinated polymer has not been reported. In this paper we report the preparation, crystal structure, IR spectroscopy, thermal stability, and the luminescence and electrochemical properties of a novel cadmium coordination polymer [Cd(pipH)(Cl)(l-Cl) 2 ] n ÁnH 2 O.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the crystal structure and electrochemical properties of catena-poly[[chlorido(piperazin-1-ium–κN))cadmium(II)]-di-μ-chlorido]monohydrate

Mabrouk¹,

Dkhili²,

Besbes-Hentati³

et al. 2015

Res Chem Intermed

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A novel Cd(II) coordination polymer [Cd(C 4 H 11 N 2 )(l-Cl) 2 Cl] n ÁnH 2 O with a supramolecular structure has been synthesized by reaction of CdCl 2 2Á5H 2 O with piperazine. The compound was investigated by X-ray diffraction, electrochemistry, and IR spectroscopy. The CdCl 3 (C 4 H 11 N 2 )ÁH 2 O entity in the compound forms a 1D coordination polymer as a result of the bridging function of the chlorine atoms Cd-Cl 2 -Cd. Adjacent 1D coordination polymers are connected by (O,N,C)-H…Cl, (O,N)-H…Cl, and N-H…O hydrogen bonds, generating a three-dimensional supramolecular network. With this atomic arrangement, the complex can form an electroactive film on a platinum electrode by anodic oxidation in acetonitrile solution.

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“…The electrochemical characterization of the process was done by using chronocoulometry, voltammetry and exhaustive coulometry 6, 7. The oxidation involved the aniline N atom and resulted to be a two‐step one‐electron reversible process, coupled with irreversible chemical reactions (EC mechanism).…”

Section: Introductionmentioning

confidence: 99%

Analytical Determination and Electrochemical Characterization of the Oxazolidinone Antibiotic Linezolid

Merli¹,

Pretali²,

Fasani³

et al. 2011

Electroanalysis

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Linezolid belongs to a class of antibiotics known as oxazolidinones. It is receiving great attention due to its activity toward multidrugs resistant bacteria, and simple and cheap methods for the analysis of this compound in pharmaceutical preparations are required. In this work, the electrochemistry of the antibiotic linezolid was investigated and a differential pulse voltammetric method based on the oxidation of the oxazolidinonic compound at a glassy carbon electrode has been developed and optimized for its determination; LOD of 50 mg L À1 and a linearity up to 200 mg L À1 were reported. The electrochemical process was studied by using different electrochemical techniques and confirmed by HPLC-MS/MS.

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Comportement electrochimique anodique de divers neuroleptiques en milieu aqueux et non-aqueux

Cited by 16 publications

References 14 publications

Tentative correlation between the electrochemical oxidation of neuroleptics and their pharmacological properties

Tentative correlation between the electrochemical oxidation of neuroleptics and their pharmacological properties

Investigation of the crystal structure and electrochemical properties of catena-poly[[chlorido(piperazin-1-ium–κN))cadmium(II)]-di-μ-chlorido]monohydrate

Analytical Determination and Electrochemical Characterization of the Oxazolidinone Antibiotic Linezolid

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