Componentes Químicos E Atividade Antimicrobiana De

Montrucchio, Deise Prehs; Miguel, Obdúlio Gomes; Miguel, Marílis Dallarmi; Monache, Franco Delie; Carvalho, J. L. S.

doi:10.5380/acd.v6i2.6109

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“…The 70% ethanolic extract from the leaves of S. marginata yielded 15 pure compounds: 3-O-D-β-glucopyranosylsitosterol, 19 the saponins pulsatilla saponin D, 20 hederacolchiside A 1 , 21 salzmannianoside B, 11 and compound 1, the flavonoids quercetin 3-O-α-L-rhamnopyranoside, 22 epicatechin, 23 cassiaoccidentalin A (2), 24 27 and compound 4, and the proanthocyanidins proanthocyanidins A-1 and A-2 28 and cinnamtannin B-1 (Figure 1). 29 The absolute configurations of the sugar moieties were verified by measurement of the optical rotation of each purified sugar after acid hydrolysis of fractions A and B.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

et al. 2014

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A phytochemical study of a Serjania marginata leaf extract with antiulcer activity afforded 15 compounds, including the new 3-O-α-l-arabinopyranosyl(1→3)-α-l-rhamnopyranosyl(1→2)[β-d-glucopyranosyl(1→4)]-α-l-arabinopyranosyloleanolic acid (1) and 7,5″-anhydroapigenin 8-C-α-(2,6-dideoxy-5-hydroxy-ribo-hexopyranosyl)-4'-O-β-d-glucopyranoside (4). The structures of the new compounds were determined by spectroscopic analysis, including 1D and 2D NMR techniques, mass spectrometry, and chemical methods. Compound 4 is a C-hexopyranosylapigenin with an unusual cyclic ether linkage between C-5″ and C-7 of apigenin. The isolated proanthocyanidins have high antioxidant activities, and these compounds are probably responsible for the gastroprotective effect of the extract.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

et al. 2014

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“…As the 13 C-NMR data of 4 are not available in the literature consulted, we performed a calculation in order to estimate the chemical shifts of 4 by subtracting the effect of the OH group in C-3 and adding the OCH 3 group in its place, and then calculating the α, β and γ effects on the carbon chemical shift (Table 2). Lupeol is a common triterpene with this skeleton and hence the Dδ C calculation was based on its 13 C-NMR data. 29 These calculations allowed the identification of 3β-methoxy-lup-20(29)-ene which is reported for the first time in Olacaceae.…”

Section: Chemistrymentioning

confidence: 99%

“…2 It belongs to the Olacaceae which has 24 genus and 150 species. 3 From this family, several chemical classes have been isolated such as alkaloids, [4][5][6][7][8][9] proanthocyanidins, 10,11 chromones, 12 steroids, 13 flavonoids, 12,14 isoprenoids, 12 polyisoprenoids, 15 diterpenes, 16,17 sesquiterpenes, 9 triterpenes, 10,13,[18][19][20] and glycerol-derivatives. 12 Previous phytochemical studies on M. guianensis reported the isolation of triterpenes, 18,20 xanthone and minquartynoic acid.…”

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confidence: 99%

Triterpenes from Minquartia guianensis (Olacaceae) and in vitro antimalarial activity

Cursino¹,

Núñez²,

Paula³

et al. 2012

Quím. Nova

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Minquartia guianensis, popularly known as acariquara, was phytochemically investigated. The following triterpenes were isolated from the dichloromethane extract of leaves: lupen-3-one (1), taraxer-3-one (2) and oleanolic acid (3). The dichloromethane extract of branches yielded the triterpene 3β-methoxy-lup-20(29)-ene (4). The chemical structures were characterized by NMR data. Plant extracts, substance 3, squalene (5) and taraxerol (6), (5 and 6 previously isolated), were evaluated by in vitro assay against chloroquine resistant Plasmodium falciparum. The dichloromethane extract of leaves and the three triterpenes assayed have shown partial activity. Thus, these results demonstrated that new potential antimalarial natural products can be found even in partially active extracts

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ANTIFUNGAL POTENTIAL OF EXTRACTS AND FRACTIONS OF Randia nitida LEAVES ON SOYBEAN PATHOGENS AND THEIR PHYTOCHEMISTRY

et al. 2016

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-This study aimed to evaluate the antifungal activity of methanol extract and fractions of leaves of Randia nitida (Kunth) DC on Colletotrichum truncatum (Schw.) Andrus & Moore, Rhizoctonia solani Kühn and Sclerotinia sclerotiorum (Lib.) De Bary and perform chemical and antioxidant activity tests. Crude methanol extract (EBM) and fractions (hexane = FHX, dichloromethane = FDM and ethyl acetate = FAE) underwent classical phytochemical analysis and determination of total phenols, flavonoids and antioxidant activity. Samples were individually incorporated into PDA culture mediums (potato-dextrose-agar) at concentrations of 10, 20, 40, 80 and 160 µg mL -1 of extract or fraction. Mycelial growth was evaluated when control reached the edge of the plate. Phytochemical results indicated that flavonoids, steroids and triterpenoids are the major chemical constituents in both EBM and fractions. Total phenols, flavonoids and antioxidant activity were higher for FAE and EBM, followed by FDM and FHX; however, the latter showed higher content of steroids and triterpenoids compared to the other fractions. For C. truncatum, R. solani and S. sclerotiorum, the most efficient fractions were respectively FAE, FDM and FHX, all of them in the highest concentration (160 µg mL -1). The highest inhibition rate was observed against S. sclerotiorum, reaching 93.75%. We concluded that all fractions have antifungal activity on the plant pathogens, being FHX the most active against S. sclerotiorum, which might have been due to the presence of steroids and triterpenes.Keywords: Alternative control. Sclerotinia sclerotiorum. Rhizoctonia solani. Colletotrichum truncatum. Secondary metabolites. DPPH. foram submetidas a análise fitoquímica clássica e determinado os fenóis totais, flavonoides e atividade antioxidante. As amostras foram incorporadas, individualmente, ao meio de cultura BDA (batata-dextrose-ágar) nas concentrações de: 10, 20, 40, 80 e 160 µg mL -1 de extrato ou fração. O crescimento micelial foi avaliado quando a testemunha alcançou a borda da placa. Os resultados fitoquímicos indicaram que os flavonoides, esteroides e triterpenos são os constituintes químicos majoritários no EBM e nas frações . O teor de fenóis totais, flavonoides e a atividade antioxidante foi maior para a fração FAE e extrato EBM, seguido da fração FDM e da FHX, contudo a fração hexânica apresentou maior conteúdo de esteroides e triterpenos em relação as demais frações . Para os três fungos, as frações eficientes foram as frações FAE, FDM e FHX, respectivamente, todas na maior concentração estudada (160 µg mL -1 ). A maior porcentagem de inibição foi observada frente ao patógeno S. sclerotiorum, chegando a 93,75%. Conclui-se que todas as frações apresentam atividade antifúngica sobre os fitopatógenos e a fração FHX foi a mais ativa frente a Sclerotinia sclerotiorum, provavelmente pela presença de esteroides e triterpenos. POTENCIAL ANTIFÚNGICO DE EXTRATOS E FRAÇÕES DE Palavras

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Componentes Químicos E Atividade Antimicrobiana De

Cited by 3 publications

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Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

Unusual C,O-Fused Glycosylapigenins from Serjania marginata Leaves

Triterpenes from Minquartia guianensis (Olacaceae) and in vitro antimalarial activity

ANTIFUNGAL POTENTIAL OF EXTRACTS AND FRACTIONS OF Randia nitida LEAVES ON SOYBEAN PATHOGENS AND THEIR PHYTOCHEMISTRY

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