Component Analysis of Esophageal Cancer Incidence in Kazakhstan

Igissinov, Saginbek; Igissinov, Nurbek; Moore, Malcolm A; Kozhakhmetov, Saken; Igissinova, Gulnur; Сарсенова, С. В.; Aldiyarova, Gulmira; Bilyalova, Zarina; Zhabagin, K. T.; Manambayeva, Z. A.

doi:10.7314/apjcp.2013.14.3.1945

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Since 2011, screening for CRC has been carried out in Kazakhstan among the entire population aged 50 to 70 every two years using fecal occult blood test and colonoscopy procedure. This is a continuation of several studies of the dynamics in malignant neoplasms incidence by the method of component analysis, we conducted studies in this direction earlier (Igissinov et al, 2012;Igissinov et al, 2013;Igissinov et al, 2015;Kuanyshkaliyeva et al, 2016;Igissinov et al, 2019), assessing the influence of demographic factors, risk factors and their combination at the same time, taking into account gender, ethnic groups in different localities. The aim of the study was to use principal components analysis to shed light on the dynamics of the incidence of CRC in Kazakhstan.…”

Section: Introductionmentioning

confidence: 88%

Trends of Colorectal Cancer Incidence in Kazakhstan

Mauyenova

Zhadykova

Khozhayev

et al. 2021

Asian Pac J Cancer Prev

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Background and objective: Colorectal cancer (CRC) remains one of the most widespread human malignancies. The aim of this study was to study trends of the incidence of CRC in Kazakhstan. Materials and Method: This retrospective study was done using descriptive and analytical methods of oncoepidemiology. Results: During the study period from 2009 to 2018, 28,950 new cases of CRC were recorded, 13,779 (47.6%) cases were allocated to men and 15,171 (52.4%) to women. It was found that the incidence rate of CRC increased from 14.79 (2009) to 17.72 in 2018 and the overall growth was 2.93 cases per 100,000. This increase was due to the age structure -∑Δ A =+1.42, the risk of acquiring illness -∑Δ R =+1.31, and their combined effect -∑Δ RA =+0.20. The component analysis results revealed that the increase in the number of patients with CRC was mainly due to the growth of the population (ΔP=+37.7%), changes in age structure (Δ A =+26.6%), and changes associated with the risk of acquiring illness (Δ R =+24.6%). The number of patients (both sexes) was increasing in many regions largely due to the influence of the age structure of the population. In addition, it was found that growth in the number of patients in most regions, both men and women, was associated primarily with the risk of acquiring illness. Conclusion: The findings of the current study showed increasing trends in the incidence of CRC in all regions of the country. These changes were mainly influenced by demographic factors (population size and age structure), risk of acquiring the disease, and their combined effect.

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Section: Introductionmentioning

confidence: 88%

Trends of Colorectal Cancer Incidence in Kazakhstan

Mauyenova

Zhadykova

Khozhayev

et al. 2021

Asian Pac J Cancer Prev

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“…Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the two most common types of EC, while Less than 1% are sarcomas or small cell carcinomas, with very rarely reported incidence of esophageal lymphoma, melanoma, or carcinoid [ 3 ]. The main risk factors for EC in Asian belt till now have not been understood very well [ 5 ]. Poor nutritional status, low intake of fruits and vegetables, low socioeconomic status, smoking and excessive alcohol consumption are known as putative risk factors [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with esophageal cancers, diagnosed at tertiary level in Afghanistan: a descriptive cross-sectional study

et al. 2022

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Background: Worldwide, esophageal cancer (EC) is a common cancer in term of incidence and mortality and is the 4th common cancer in Afghanistan. Current study aimed to evaluate the profile of risk factors for EC among patients diagnosed at tertiary level in Afghanistan. Methodology: A descriptive cross-sectional study was carried out between January 2019 up to February 2021 including all esophageal cancers diagnosed at pathology department of French Medical Institute for Mothers and Children, Afghanistan. Result: 240 diagnosed cases were analyzed, in which 59.40% of squamous cell carcinoma and 41.07% Adenocarcinoma. Both histopathological type of were predominantly diagnosed in males. The majority of the patients were residents of rural areas. More than 80% of the patients were illiterate with only less than 2% completing higher education. Majority of the patients were laborers and farmers while less than 10% were employed. According to income assessment, more than 80% were from low-income household, the rest from middle-income and none from high-income family. Oral snuff consumption was noted in 33.9% of squamous cell carcinoma patients and 40% adenocarcinoma patients whereas, family history of esophageal cancer was observed in 37.8% and 36.7% in both types of carcinomas, respectively. More than 60% of both types of carcinomas patients were hot tea drinkers. Conclusion: Current study demonstrated that most patients diagnosed with esophageal cancers were male, uneducated, belongs to low-income groups, lives in rural areas. These findings suggest distribution of esophageal cancer in specific socioeconomic groups, clearly demonstrating the need further analytical study.

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“…Such analysis of changes of certain factors affecting the TC incidence will help the cancer care providers to identify the causative factors and make cancer control in the studied areas of Kazakhstan more targeted. The analysis also allows the regional oncology managers to properly account for the TC incidence trends as an important indicator of public cancer care , as well as to assess the status of detection and the quality of diagnostics (Igissinov et al, 2012;Igissinov et al, 2013;Igissinov et al, 2015;Kuanyshkalieva et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Cancer in Kazakhstan: Component Analysis of Incidence Dynamics

Igissinov

Kozhakhmetov

Zhantubetova

et al. 2019

Asian Pac J Cancer Prev

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Background: The International Agency for Research on Cancer (IARC) reports that 567,000 new cases of thyroid cancer (TC) were registered in the world in 2018, and the age-standardized incidence rate was 6.7 per 100,000. The Global Cancer Observation forecasts a 35% growth in the number of new cases worldwide by 2040. The number of patients with TC in Kazakhstan is also increasing steadily. This investigation was the first epidemiological study of TC trends by component analysis among the population of Kazakhstan. This paper presents the results of the component analysis of TC incidence trends in Kazakhstan. Methods: The study covers primary data of TC cases (ICD 10-C73) registered throughout Kazakhstan from 2009 to 2018. TC incidence trends were evaluated using component analysis according to the methodological recommendations. Results: 5,559 new TC cases were registered during the 10-year study period. The average age of patients was 52.0±0.2 years, the average annual age-standardized rate in 2009-2018 was 3.3±0.2 0 / 0000 , with a constant upward trend (Т=+6.6%). According to the component analysis results, the increase in incidence was mainly due to the combined effect of the two factors: the increased disease risk (Δ R =+61.7%), and the population growth (Δ P =+15.4%). Conclusion: The noted increase in incidence was mainly caused by the changes in risk factors, such as the worsening environmental aspects and the increase in detection of clinically non-manifesting cases. The results of the study shall be taken into account when planning anticancer activities for TC.

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Component Analysis of Esophageal Cancer Incidence in Kazakhstan

Cited by 10 publications

References 6 publications

Trends of Colorectal Cancer Incidence in Kazakhstan

Trends of Colorectal Cancer Incidence in Kazakhstan

Risk factors associated with esophageal cancers, diagnosed at tertiary level in Afghanistan: a descriptive cross-sectional study

Thyroid Cancer in Kazakhstan: Component Analysis of Incidence Dynamics

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