Complications of type 2 diabetes in Iranian population: An updated systematic review and meta-analysis

Moradi, Yousef; Baradaran, Hamid Reza; Djalalinia, Shirin; Chinekesh, Ahdieh; Khamseh, Mohamad Ebrahim; Dastoorpoor, Maryam; Sioofy‐Khojine, Amir‐Babak; Saed, Lotfollah; Qorbani, Mostafa

doi:10.1016/j.dsx.2019.05.018

Cited by 23 publications

(13 citation statements)

References 29 publications

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“…4,5 An updated systematic review and meta-analysis of patients with T2DM in Iran showed that the combined prevalences of cardiovascular disease, retinopathy, and neuropathy were 33% (95% CI: 16-49%), 36% (95% CI: 27-45%), 43% (95% CI: 27-60%), respectively. 6 Moreover, the prevalence of microalbuminuria was 26%. 7 Cardiovascular disease caused by hypertension and dyslipidemia 8 is the major cause of mortality and morbidity in T2DM patients.…”

Section: Introductionmentioning

confidence: 98%

Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study

Aliyari¹,

Hajizadeh²,

Aminorroaya³

et al. 2020

DMSO

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Background: Increase in the prevalence of type 2 diabetic mellitus (T2DM) as a complex disease, its complications, and spread has become a dominant global health threat in recent decades. Objective: The aim of the current study was to investigate the impact of risk factors and transition probability on the development and progression of the late complications of T2DM. Methods: This study was an open cohort one which was conducted at Isfahan Endocrine and Metabolism Research Center (IEMRC). The data were collected from 1993 to 2018. The sample size consisted of 2519 adults diagnosed with type 2 diabetes. We applied the homogeneous multistate models including no complication, retinopathy alone, coronary artery disease (CAD), microalbuminuria, retinopathy and CAD, and the final absorbing mortality states. Results: Based on our results, time-varying hypertension strongly intensified the hazard of transition to mortality in CAD, no complication, CAD and retinopathy, and retinopathy patients by 4.99, 4.09, 3.42, and 2.65 times, respectively. Hypertension seemed to be a potential factor for the transition of microalbuminuria to no complication in diabetic patients. One-unit increase in LDL increased the hazard ratio of transition from CAD, and retinopathy and CAD to mortality by 1.8% and 2.4%, respectively. Moreover, one level increase in time-varying HbA1c increased the hazard ratio of transition to retinopathy and mortality among no complication diabetic patients by 30% and 67%, respectively. One level increase in time-varying HbA1c also intensified the hazard ratio of transition from retinopathy to mortality by 45%. The same level of increase in time-varying HbA1c also intensified the hazard ratio of transition from CAD alone to CAD and retinopathy, and microalbuminuria to retinopathy by 26% and 50%, respectively. Conclusion: In addition to glycemic control, our study indicates that controlling hypertension and hyperlipidemia is more effective in reducing mortality and the diabetic macro-and microvascular complications.

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Section: Introductionmentioning

confidence: 98%

Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study

Aliyari¹,

Hajizadeh²,

Aminorroaya³

et al. 2020

DMSO

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“…Esto contrasta al menos con otro reporte en el que las cifras de pacientes con complicaciones asociadas a dm2, así como presencia de comorbilidades en la muestra estudiada fue significativamente menor (4.6%) que las reportadas en este trabajo. 11 Si bien el impacto de la dm2 en la salud se ha estudiado desde hace mucho tiempo, globalmente existen similitudes y diferencias en cuanto a su comportamiento en diversas poblaciones, tal es el caso de lo reportado por Moradi y cols., 12 quienes detectaron una presencia de retinopatía de 36%, neuropatía 38% y nefropatía 43% en pacientes con dm2, en comparación con ese estudio, nosotros reportamos valores de retinopatía de 2.9%, neuropatía 18% y nefropatía 3.6%, estas diferencias tan grandes pueden estar relacionadas con el contexto sociodemográfico, económico y evolución de la enfermedad. Sería de gran interés, en el contexto médico y social, profundizar más en estudios que expliquen el comportamiento de la Respecto al inicio de insulinización, se ha determinado en otro estudio que los factores asociados a ésta fueron edad de 50-59 años, así como uso de uno o más hipoglucemiantes orales en más de 65% de pacientes; 13 en el presente trabajo la media de edad para el uso de insulina fue de 56.6 años y casi dos terceras partes de los pacientes consumían dos hipoglucemiantes.…”

Section: Discussionunclassified

Características y prevalencia de pacientes con diabetes mellitus tipo 2 bajo prescripción de hipoglucemiantes orales que cumplen criterios de insulinización

Silva¹,

Mendoza²

2022

Atención Familiar

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Objetivo: evaluar las características y prevalencia de pacientes con diabetes mellitus tipo 2 (dm2) bajo prescripción de hipoglucemiantes orales que cumplen con criterios de insulinización. Métodos: estudio transversal descriptivo. Se analizaron 367 expedientes de pacientes con dm2, edad de 30 a 70 años de la Unidad de Medicina Familiar No. 20 en Ciudad de México, con tres meses mínimo de tratamiento con hipoglucemiantes orales. Se registraron características sociodemográficas y clínicas de la dm2, tipo de hipoglucemiante oral, comorbilidades y se identificaron los criterios para inicio de tratamiento con insulina de acuerdo con la Asociación Americana de Diabetes y la Asociación Europea para el Estudio de la Diabetes. Resultados: de la totalidad de expedientes, se observó una media de edad 56.5 años (de±9.0), 58.3% estaba compuesto por mujeres y 50.1% estaba controlado (n=184). 37.6% de pacientes cumplió criterios para insulinización, sus características fueron: edad de 61 a 70 años, 42.8%, mujeres, 52.9%, dedicados al hogar, 32.6%, casados, 66.7%, tiempo de evolución de dm2 1-5 años, 32.6%; 95.7% presentó comorbilidades, obesidad, 52.9%, hipertensión arterial, 52.2% y dislipidemia, 51.4%; neuropatía, 18.8%, nefropatía, 3.6% y retinopatía, 2.9%. Conclusiones: existió un alto porcentaje de pacientes descontrolados bajo prescripción de hipoglucemiantes orales, más de una tercera parte reunieron criterios para inicio de terapia con insulina, mientras que la mayoría de estos presentó algún tipo de comorbilidad.

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“…Requires lifelong drug therapy with blood glucose-lowering agents, a modified lifestyle that includes a balanced and healthy diet and regular exercise in both cases [16,17] . People with diabetes are more susceptible to foot ulcers than non-diabetics any foot injury is serious in the case of patients with diabetes as the severity of diabetic foot infections ranges from superficial to the deep infection involving the bone [18] . Types of infection include cysts, cellulitis, myositis, septic arthritis, necrotizing fasciitis, osteomyelitis, and tendonitis.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Aerobic Bacteria Isolated From Diabetics Foot Infection Locally and Antibiotics Influence

Jaafar¹

2020

ATMPH

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Diabetic foot infection is one of the terrible complications of diabetes leading to morbidity and mortality. This study evaluated the resistance and sensitivity of isolated aerobic bacterial frequencies that were isolated from patients with diabetic food for the commonly used antibiotics to assist in identifying empirical therapy.This study aimed to determine the antibiotic sensitivity and resistance pattern to detect aerobic bacterial pathogens present in diabetes pus against 13 commonly used standard antibiotics: erythromycin, oxacillin, chloramphenicol, ciprofloxacin, vancomycin, methycillin, amoxicillin, cephoprazin, and biphenylpropionone.Forty patients with a diabetic foot infection, including 28 males and 12 females from Al Najaf center for diabetes and endocrine in Al-Sadir medical city, were clinically sampled for 5 months. All swabs from these 40 patients showed a positive culture and a total of 98 isolates were isolated.Standard aerobic microbiological techniques were used to process clinical specimens. Also the Kirby-Bauer disc diffusion method was used to study the antimicrobial susceptibility pattern.The Infections are generally due to Gram-positive bacteria. The most isolated Gram-positive bacteria was Staphylococcus aureus bacteria and streptococcus spp. followed by Staphylococcus aureus and Bacillus spp. (49%, 34%, 13%and 3%), respectively. While Proteus spp. and Pseudomonas spp. the most isolated Gram-negative bacteria followed by Escherichia coli and Klebsiella spp. and Enterobacter spp. and Acenetobacter baumannii (32%, 27%, 19%, 11%, 5% and 5%), respectively.

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Complications of type 2 diabetes in Iranian population: An updated systematic review and meta-analysis

Cited by 23 publications

References 29 publications

<p>Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study</p>

<p>Multistate Models to Predict Development of Late Complications of Type 2 Diabetes in an Open Cohort Study</p>

Características y prevalencia de pacientes con diabetes mellitus tipo 2 bajo prescripción de hipoglucemiantes orales que cumplen criterios de insulinización

Aerobic Bacteria Isolated From Diabetics Foot Infection Locally and Antibiotics Influence

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