Complexes of different nitrogen donor heterocyclic ligands with SbCl3 and PhSbCl2 as potential antileishmanial agents against SbIII-sensitive and -resistant parasites

Lizarazo-Jaimes, Edgar H.; Reis, Priscila G.; Bezerra, Filipe M.; Rodrigues, Bernardo L.; Monte-Neto, Rubens L.; Melo, Maria Norma; Frézard, Frédéric; Demicheli, Cynthia

doi:10.1016/j.jinorgbio.2013.12.001

Cited by 17 publications

(9 citation statements)

References 38 publications

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“…We have payed special attention to quinoline, which constitutes the central nucleus of sitamaquine (25,26), acridine (27,28), quinoxaline (29)(30)(31), and coumarins (32,33). On the other hand, nitrofuran compounds (34,35), the most relevant registered as nifurtimox, and derivatives of the benzodioxol core (36) have been selected.…”

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confidence: 99%

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Baquedano

Alcolea

Toro

et al. 2016

Antimicrob Agents Chemother

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A series of new selenocyanates and diselenides bearing interesting bioactive scaffolds (quinoline, quinoxaline, acridine, chromene, furane, isosazole, etc.) was synthesized, and their in vitro leishmanicidal activities against Leishmania infantum amastigotes along with their cytotoxicities in human THP-1 cells were determined. Interestingly, most tested compounds were active in the low micromolar range and led us to identify four lead compounds (1h, 2d, 2e, and 2f) with 50% effective dose (ED 50 ) values ranging from 0.45 to 1.27 M and selectivity indexes of >25 for all of them, much higher than those observed for the reference drugs. These active derivatives were evaluated against infected macrophages, and in order to gain preliminary knowledge about their possible mechanism of action, the inhibition of trypanothione reductase (TryR) was measured. Among these novel structures, compounds 1h (3,5-dimethyl-4-isoxazolyl selenocyanate) and 2d [3,3=-(diselenodiyldimethanediyl)bis(2-bromothiophene)] exhibited good association between TryR inhibitory activity and antileishmanial potency, pointing to 1h, for its excellent theoretical ADME (absorption, distribution, metabolism, and excretion) properties, as the most promising lead molecule for leishmancidal drug design.

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confidence: 99%

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Baquedano

Alcolea

Toro

et al. 2016

Antimicrob Agents Chemother

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“…Few number of the absorption bands in the FTIR spectrum means that the symmetry of the complex is very good. A wide intense absorption band around 3428 cm −1 is due to stretching vibration of hydroxyl [ 43 , 44 ]. This indicates that there are the coordinated water or lattice water molecules in the complex.…”

Section: Resultsmentioning

confidence: 99%

Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex Containing 2,2′-Bipyridine

Liu

Wang

Zang

2018

Bioinorganic Chemistry and Applications

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A Cu(II) complex [Cu(bipy)(H2O)2(SO4)]n (bipy = 2,2′-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains. Under the condition of physiological pH, the interaction mechanism between the complex and hsDNA was explored with acridine orange as a fluorescence probe by spectroscopic methods. The binding modes between the complex and hsDNA were the electrostatic and embedded modes.

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“…14) [28]. The crystal structures of 76 and 77 are shown distorted square pyramid geometry with a five-coordinated Sb center.…”

Section: Antimony Complexes With Ligands Containing Nitrogen Donor Atomsmentioning

confidence: 98%

“…All Sb(III) complexes were characterized by elemental analysis, FT-IR, far-FT-IR, differential thermal analysis-thermogravimetry, X-ray diffraction, and conductivity measurements. The geometries around the antimony are either ionic 2-Mercaptopyrimidine (PMT) [9] octahedral (Oh) (2,3,16), cis-square pyramidal (cis-SP) (4,6,21,22), transsquare pyramidal (trans-SP) (5,17,18,26) and b,c,d-Cl or Br-square pyramidal (b,c,d-Cl or Br-SP) (7,19,20,12) and ionic salt (23), pseudo trigonal bipyramidal (ψ-TBP) (27,29), dimer (28) and neutral octahedral (29) [5-9] (Fig. 3).…”

Section: Antimony Complexes Of Thiones/thioles Ligandsmentioning

confidence: 99%

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Recent advances on antimony(III/V) compounds with potential activity against tumor cells

Hadjikakou

Öztürk

Banti

et al. 2015

Journal of Inorganic Biochemistry

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Complexes of different nitrogen donor heterocyclic ligands with SbCl3 and PhSbCl2 as potential antileishmanial agents against SbIII-sensitive and -resistant parasites

Cited by 17 publications

References 38 publications

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex Containing 2,2′-Bipyridine

Recent advances on antimony(III/V) compounds with potential activity against tumor cells

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