Recent advances on antimony(III/V) compounds with potential activity against tumor cells

Hadjikakou, Sotiris K.; Öztürk, I.I.; Banti, Christina N.; Kourkoumelis, Nikolaos; Hadjiliadis, Nick

doi:10.1016/j.jinorgbio.2015.06.006

Cited by 74 publications

(24 citation statements)

References 38 publications

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“…Several compounds containing bismuth complexes have shown promising in vitro activities against gastric ulcers caused by Helicobacter pylori as well as its usage as a radio-therapeutic agent for cancer treatment [26,76]. Similarly, there have been increased interest in the biological application of antimony based compounds and have been used against microbes and parasites [6]. Its major use, however, is in the treatment of leishmaniasis [31].…”

Section: Some Biological Potential Of Bismuth and Antimony Dithiocarbmentioning

confidence: 99%

“…In addition, the straightforwardness of their synthesis has also contributed to their increased attention [4]. The two elements, bismuth (Bi) and antimony (Sb), are both in Group 15 (pnictogen) of the Periodic Table [5,6]. Bismuth is the heaviest element of this group and is often referred to as a "green" metal due to its benign nature and low toxicity compared to the other group 15 elements such as arsenic and antimony [5].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies, reactivity and the synthesis of different transition metal dithiocarbamate compounds, with diverse structural geometry have been carried out [19]. This has been due to their ease of synthesis [19] and their diverse applications in medicine, organic synthesis, agriculture, and recently as precursors for metal sulphide nanoparticles [18].Bismuth and antimony compounds have been reported to show great potential as medicinal agents [5,6] but their complexes with dithiocarbamate have not been extensively studied. However, the few studied ones have shown a wide range of chemistry and biological activities.…”

mentioning

confidence: 99%

“…Bismuth and antimony compounds have been reported to show great potential as medicinal agents [5,6] but their complexes with dithiocarbamate have not been extensively studied. However, the few studied ones have shown a wide range of chemistry and biological activities.…”

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Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes

Adeyemi

Onwudiwe

2020

Molecules

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Interest in the synthesis of Bi(III) and Sb(III) dithiocarbamate complexes is on the rise, and this has been attributed to their wide structural diversity and their interesting application as biological agents and in solid state/materials chemistry. The readily available binding sites of the two sulphur atoms within the dithiocarbamate moiety in the complexes confers a wide variety of geometry and interactions that often leads to supramolecular assemblies. Although none of the bismuth or antimony metals are known to play any natural biological function, their dithiocarbamate complexes, however, have proven very useful as antibacterial, antileishmanial, anticancer, and antifungal agents. The dithiocarbamate ligands modulate the associated toxicity of the metals, especially antimony, since bismuth is known to be benign, allowing the metal ion to get to the targeted sites; hence, making it less available for side and other damaging reactions. This review presents a concise chemistry and some known biological potentials of their trivalent dithiocarbamate complexes.

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Section: Some Biological Potential Of Bismuth and Antimony Dithiocarbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes

Adeyemi

Onwudiwe

2020

Molecules

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“…Antimony has been used as a drug for over more than 100 years. The use of antimony in medicine has been reviewed by Hadjikakou et al [9].…”

Section: Introductionmentioning

confidence: 99%

Novel Antimony(iii) Halide Complexes With Some N-Alkyl Thioureas: Synthesis, Characterization and Study of Their Effect Upon the Catalytic Oxidation of Linoleic Acid to Hydroperoxylinoleic Acid by Lipoxygenase

Öztürk

2016

J. Turk. Chem. Soc., Sect. A: Chem.

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C) spectroscopy and TG-DTA analysis. The reactions of N-methylthiourea (NMTU) and N-ethylthiourea (NETU) with SbX3 (X = Cl or Br) in a 2:1 ligand/metal rate but unexpected products were formed in a 3:1 ligand/metal rate. The compounds are non-electrolytes in solution and spectroscopic data of the compounds are appropriate with six coordinate octahedral geometry by three halide ions and three sulfur atoms from thiourea ligands. N-methythiourea and N-ethylthiourea ligands behave as monodentate in compounds 1-4 with the binding through sulfur. The influence of these compounds 1-4, N-methythiourea and N-ethylthiourea upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by lipoxygenase was kinetically studied.

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Metallodrugs in Medicine

Yousuf

Bashir

2020

Advances in Metallodrugs

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Recent advances on antimony(III/V) compounds with potential activity against tumor cells

Cited by 74 publications

References 38 publications

Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes

Chemistry and Some Biological Potential of Bismuth and Antimony Dithiocarbamate Complexes

Novel Antimony(iii) Halide Complexes With Some N-Alkyl Thioureas: Synthesis, Characterization and Study of Their Effect Upon the Catalytic Oxidation of Linoleic Acid to Hydroperoxylinoleic Acid by Lipoxygenase

Metallodrugs in Medicine

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