Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex Containing 2,2′-Bipyridine

Abstract

A Cu(II) complex [Cu(bipy)(H2O)2(SO4)]n (bipy = 2,2′-bipyridine) was synthesized by hydrothermal method and characterized structurally by elemental analyses, single crystal X-ray diffraction, infrared spectra, and thermogravimetry and differential scanning calorimetry. The Cu(II) was hexacoordinated by two N atoms from bipy, two O atoms from different sulfate radical anions, and two O atoms from two water molecules, forming a slightly distorted octahedral geometry, and bridged by sulfato groups into polymeric chains. Under the condition of physiological pH, the interaction mechanism between the complex and hsDNA was explored with acridine orange as a fluorescence probe by spectroscopic methods. The binding modes between the complex and hsDNA were the electrostatic and embedded modes.

Novel tetranuclear grid-like Zn(ii) complexes derived from dihydrazone pyrimidine derivatives as antitumor agents

“…Complexes 1 and 2 are embedded in base pairs of the DNA double helix, resulting in the changes in the base-stacking force. [34][35][36] According to eqn (1), the binding force of complexes 1 and 2 with DNA by monitoring the absorbance changes at 210 nm and the mode of action was initially determined. The intrinsic binding constants (K b ) were calculated to be 5.09 × 10 6 M −1 and 4.82 × 10 6 M −1 , respectively.…”