Complex formation of methylcellulose with poly(acrylic acid)

Hydrogen‐Bonded Complexes and Blends of Poly(acrylic acid) and Methylcellulose: Nanoparticles and Mucoadhesive Films for Ocular Delivery of Riboflavin

“…Previously, we have studied the complexation between PAA and MC in aqueous solutions by turbidimetric titration, isothermal titration calorimetry, transmission electron microscopy, and surface plasmon resonance (Biacore) and evaluated the effects of pH and solution concentration on the intensity of interactions and structure of IPCs formed. [12][13][14][15][16] Rheological properties of PAA-MC complexes in aqueous solutions were also reported by other authors. [17] It was established that the complexes formed have non-stoichiometric nature and contain excessive molar quantities of PAA.…”

“…All our previous studies of complexation between PAA and MC in aqueous solutions were focused on determination of the stoichiometry of complexation, [12,13] probing the complexation strength and thermodynamics, [14] evaluation of pH and concentration effects on the formation, structural organization, and stability of IPCs, [12][13][14] and the fabrication of PAA-MC based multilayered materials. [14][15][16] We have established the possibility of forming PAA-MC complexes as nanoparticles when 0.2 wt% polymer solutions were mixed at 30:70 wt% ratio at pHs 1.4, 2.4, and 3.2, [14] however, did not evaluate the stability of these colloidal suspensions to aggregation.…”

“…It is important to note that an intensive growth in the IPCs particle size observed at pH below 3.2-3.3 agrees well with our previously reported turbidimetric determination of pH crit . [12,13] The understanding of the complex formation between PAA and MC in aqueous solutions at different pHs is of significant interest for practical applications, especially for the development of novel dosage forms. Nanoparticles formed by PAA-MC complexes can be used to formulate drug delivery systems, e.g., as nano-containers for poorly soluble drugs because of presence of hydrophobic domains in the IPC structure.…”

Hydrophilic Interpolymer Associates as a Satellite Product of Reactions of Formation of Interpolymer Complexes

“…Interpolymer complexes (IPC) stabilized by hydrogen bonds were studied in considerable number of publications [1][2][3][4][5]; a review on mentioned results was given, in particular, in [6]. Interests in these compounds are dictated including the possibility of using the results for different applications in life sciences, especially in molecular biology [6].…”