Complex formation between poly(ethylene glycol) and α-cyclodextrin

Harada, Akira; Kamachi, Mikiharu

doi:10.1021/ma00212a039

Cited by 860 publications

(764 citation statements)

References 1 publication

Supporting

Mentioning

727

Contrasting

Unclassified

Order By: Relevance

“…Polyrotaxanes have supramolecular architectures with cyclodextrins (CDs) threaded in poly(ethylene glycol) (PEG) chains, they are attractive materials to biomaterials scientists and chemists [1][2][3][4][5]. As CDs and PEG have been approved by Food & Drug Administration (FDA) in pharmaceutical formulations, the polyrotaxanes exhibit great potential applications in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Zhang

et al. 2014

Nano-Micro Lett.

View full text Add to dashboard Cite

α-Cyclodextrin/poly(ethylene glycol) (α-CD/PEG) polyrotaxane nanoparticles were prepared via a self-assembly method. Anticancer drug methotrexate (MTX) was loaded in the nanoparticles. The interaction between MTX and polyrotaxane was investigated. The formation, morphology, drug release and in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles were studied. The results show that the MTX could be efficiently absorbed on the nanoparticles, and hydrogen bonds were formed between MTX and α-CDs. The typical channel-type stacking assembly style of polyrotaxane nanoparticles was changed after MTX was loaded. The mean diameter of drug loaded polyrotaxane nanoparticles were around 200 nm and the drug loading content was as high as about 20%. Drug release profiles show that most of the loaded MTX was released within 8 hours and the cumulated release rate was as high as 98%. The blank polyrotaxane nanoparticles were nontoxicity to cells. The in vitro anticancer activity of the MTX loaded polyrotaxane nanoparticles was higher than that of free MTX.

show abstract

Section: Introductionmentioning

confidence: 99%

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Zhang

et al. 2014

Nano-Micro Lett.

View full text Add to dashboard Cite

show abstract

“…Harada et al [27] studied the sequestration of polymers such as PEG within CDs. They found that α-cyclodextrins formed complexes with PEG of various molecular weights to give stoichiometric complexes in high yields.…”

Section: Cyclodextrin-based Nanoparticles For Hydrophilic Drug Complementioning

confidence: 99%

Self-assembled polysaccharide nanostructures for controlled-release applications

Myrick

Vendra

Krishnan

2014

Nanotechnology Reviews

View full text Add to dashboard Cite

Self-assembling polysaccharide nanostructures have moved to the forefront of many fields due to their wide range of functional properties and unique advantages, including biocompatability and stimulus responsiveness. In particular, the field of controlled release, which involves influencing the location, concentration, and efficacy of active pharmaceutical ingredients (APIs), diagnostics, nutrients, or other bioactive compounds, has benefited from polysaccharide biomaterials. Nanostructure formation, stimulus responsiveness, and controlledrelease performance can be engineered through facile chemical functionalization and noncovalent intermolecular interactions. This review discusses polysaccharide nanoparticles, designed for targeted and time-controlled delivery of emerging APIs, with improved in vivo retention, stability, solubility, and permeability characteristics. Topics covered include nanoparticles of cyclodextrin and cyclodextrin-containing polymers, hydrophobically modified polysaccharides, polysaccharide nanoparticles that respond to pH, temperature, or light stimulus, polysaccharide prodrug complexes, polysaccharide complexes with lipids and proteins, and other polysaccharide polyelectrolyte complexes.

show abstract

“…7 The guests may be hydrophilic or hydrophobic small molecules and polymer macromolecules, which can form inclusion complexes with cyclodextrins. Since Harada et al 8 reported linear polyethylene glycol with different molecular weights could form necklace-like inclusion complexes with α-CD named polypseudorotaxanes in 1990, many cyclodextrin inclusion complexes with polymers have been prepared in the past decades. Tallury et al 9 discovered conductive polymers such as polyanilines (PANI) could form the "host-guest" inclusion structures with β-cyclodextrins, and studied the interactions between polyanilines and β-cyclodextrins in their inclusion complexes via molecular dynamics simulations; Sajadi Tabassi et al 10 prepared the inclusion complexes of the water-soluble triblock copolymer PCL-PEG-PCL with α-CD; Semsarzadeh 11 also produced an inclusion complex between PDMS and γ-CD at room temperature in the presence of light and in the absence of mixing.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Inclusion Complex between β-Cyclodextrin and Polylactic Acid

Nan¹,

Fang²,

Jun³

2015

Polymer Korea

View full text Add to dashboard Cite

Abstract:The inclusion complexes (ICs) between polylactic acid (PLA) and β-cyclodextrin (CD) were prepared by coprecipitation method in this work. The orthogonal experiments were designed to investigate the influence of different factors on the formation of inclusion complexes. The results suggested that the optimum scheme of inclusion compounds could be obtained when the feeding ratio of CD to PLA (wt%) was 20:1, stirring speed was 6 kr/min and the stirring time was 30 min. The structures and properties of the inclusion complexes were characterized by 1 H NMR, FTIR, DSC, FT-Raman, XRD and TGA. The DSC results demonstrated that the crystallization behavior of the inclusion complexes nearly disappeared. It was found that β-CD-PLA inclusion complex had a better thermal stability compared with the neat PLA. The model of the inclusion complexes was proposed on the basis of XRD, 1 H NMR and DSC results.

show abstract

Complex formation between poly(ethylene glycol) and α-cyclodextrin

Cited by 860 publications

References 1 publication

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Self-assembled polysaccharide nanostructures for controlled-release applications

Preparation and Characterization of Inclusion Complex between β-Cyclodextrin and Polylactic Acid

Contact Info

Product

Resources

About