Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Zhang, Longgui; Su, Ting; He, Bin; Gu, Zhongwei

doi:10.1007/bf03353774

Cited by 36 publications

(23 citation statements)

References 27 publications

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“…As oxalic acid aqueous solutions absorbs at around (and below) 300310 nm ( Figure S25a), 78 the drug-release quantification from those systems containing oxalic acid was done considering the calibration curve at 352 nm, whereas drug-release from CaCl 2 -based systems was monitored at 304 nm. It is important to mention that MTX UV-vis spectra vary depending on the solvent or pH of the media, which is in agreement with the data reported in the literature 79,80 Spectra recorded in the calibration media and oxalic acid aqueous solutions are similar (peak ca. 300 nm and shoulder at 351 nm), whereas spectra recorded in CaCl 2 aqueous solution or in water showed the absorption shoulder at ca.…”

Section: Mtx-loading and Release From Na-alg Gels Beads And Filmssupporting

confidence: 91%

Paradigm Shift for Preparing Versatile M²⁺-Free Gels from Unmodified Sodium Alginate

Pérez‐Madrigal

Torras²,

Casanovas

et al. 2017

Biomacromolecules

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This manuscript describes a new route to prepare rapidly Ca-free hydrogels from unmodified sodium alginate by simply mixing with small organic molecules such as poly(carboxylic acid) compounds as cross-linker agents instead of classical divalent metal salts such as CaCl. Dimethyl sulfoxide (DMSO) was also found to induce the rapid gelation of aqueous alginate solutions. The gelation process takes place at room temperature, and depending on the composition, gels with good thermal (90-100 °C) and mechanical properties compared to classical metal-containing analogs are obtained. DMSO-based gels showed remarkable self-supporting and thixotropic properties, which can be tuned by the biopolymer concentration. Furthermore, oxalic acid-based gels show superior elasticity than HCl, CaCl and DMSO-based gels. The possibility to prepare monoliths, beads, and films of these gels provide them with significant versatility. In particular, films made of alginate and oxalic acid show good potential as synergistic anticancer drug delivery carrier. Computational studies using both quantum mechanical and classical force-field methodologies reveal that hydrogen bonding networks between water and DMSO molecules located close to the alginate chains are responsible for the stability of DMSO-based gels. In contrast, the cohesion of oxalic acid-based gels is a consequence of the coexistence of multiple ionic associations involving oxalate, alginate, and Na counterions, which stabilize the system and keep all the interacting species grouped.

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Section: Mtx-loading and Release From Na-alg Gels Beads And Filmssupporting

confidence: 91%

Paradigm Shift for Preparing Versatile M²⁺-Free Gels from Unmodified Sodium Alginate

Pérez‐Madrigal

Torras²,

Casanovas

et al. 2017

Biomacromolecules

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“…Gu et al. reported the fabrication of α‐CD/PEG polyrotaxane nanoparticles via supramolecular self‐assembly to deliver anticancer drugs . In this study, the loading of methotrexate (MTX) into the α‐CD/PEG SNPs destroyed the polyrotaxane crystal structure, with UV absorbance peaks of MTX in SNPs exhibiting a red‐shift, indicating strong interactions between MTX and SNPs.…”

Section: Supramolecular Self‐assembled Structuresmentioning

confidence: 82%

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Karim

Dou

Liu

et al. 2016

Chemistry An Asian Journal

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Recent advances in host–guest chemistry have significantly influenced the construction of supramolecular soft biomaterials. The highly selective and non‐covalent interactions provide vast possibilities of manipulating supramolecular self‐assemblies at the molecular level, allowing a rational design to control the sizes and morphologies of the resultant objects as carrier vehicles in a delivery system. In this Focus Review, the most recent developments of supramolecular self‐assemblies through host–guest inclusion, including nanoparticles, micelles, vesicles, hydrogels, and various stimuli‐responsive morphology transition materials are presented. These sophisticated materials with diverse functions, oriented towards therapeutic agent delivery, are further summarized into several active domains in the areas of drug delivery, gene delivery, co‐delivery and site‐specific targeting deliveries. Finally, the possible strategies for future design of multifunctional delivery carriers by combining host–guest chemistry with biological interface science are proposed.

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“…Hydrophobic cinnamic acid was attached to the ends of the PEG chains in order to increase the space between the cyclodextrin rings, providing space for DOX to bind. This system can also be used to transport the drug methotrexate 24 .…”

Section: Self-assembled Nanoparticles As Delivery Vehiclesmentioning

confidence: 99%

“…Drugs are then added to the finished NP. Adapted with permission from 24 . B) Graphene functionalized with shielding molecules and ligands.…”

Section: Figmentioning

confidence: 99%

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

Trase

Ren

et al. 2016

Journal of Nanomaterials

204

130

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Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this article, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting and physical targeting), compare methods of action, advantages, limitations, and the current stage of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.

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Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Cited by 36 publications

References 27 publications

Paradigm Shift for Preparing Versatile M²⁺-Free Gels from Unmodified Sodium Alginate

Paradigm Shift for Preparing Versatile M²⁺-Free Gels from Unmodified Sodium Alginate

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

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Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery

Cited by 36 publications

References 27 publications

Paradigm Shift for Preparing Versatile M2+-Free Gels from Unmodified Sodium Alginate

Paradigm Shift for Preparing Versatile M2+-Free Gels from Unmodified Sodium Alginate

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Design of Nanoparticle-Based Carriers for Targeted Drug Delivery

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Resources

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Paradigm Shift for Preparing Versatile M²⁺-Free Gels from Unmodified Sodium Alginate

Paradigm Shift for Preparing Versatile M²⁺-Free Gels from Unmodified Sodium Alginate