Complex Compounds of Sm(III) with Chlorhexidine Synthesis, characterization, luminescent properties and antibacterial activity

Abstract

Three new samarium(III) complex compounds with chlorhexidine as ligand and mixed ligands chlorhexidine/o-phenanthroline have been prepared and characterized by elemental and thermogravimetrical analyses, infrared, electronic and luminescence spectra. The complexes corresponded to the formulas: [Sm(CHX)(NO3)2]� NO3, [Sm(CHX)(o-phen)2]� (NO3)3 and [Sm2(CHX)(o-phen)2(NO3)4]�(NO3)2, where CHX was the chlorhexidine. Chlorhexidine acted as neutral tetradentate NNNN donor, coordinating through the four imine nitrogen atoms. The two mixed ligands complexes showed a strong luminescent emission in solid state, characteristic of samarium(III) ion. The metal complexes and the chlorhexidine diacetate were in vitro evaluated for their antimicrobial activity against two Gram negative bacteria. The results revealed that all compounds were very effective in reducing the bacterial growth rate, even at low concentration.

In Vivo Antimalarial Test of Artocarpin and in vitro Antimalarial Test of Artonin M Isolated from Artocarpus

“…The results of in vitro antimalaria of 2 showed that this compound exhibits very high activity against Plasmodium, giving an IC50 value of 0.3 µg/mL (5.976 x 10 -7 M), and this is comparable with the control positive chloroquine with an IC50 value of 3 x 10 -7 M. This value is stronger than the antimalarial drug from the organotin (IV) compound, which has been reported lately [9,10,16] and may be better than other synthetic compounds having antimalarial activity which have been reported by others [17][18][19][20]. The data of activity test can be seen in Figure 8 and Table 2, while the data for the chloroquine are in Figure 9.…”

The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine

“…Alexander Fleming highlighted the importance of chemistry research in designing and modifying molecules to develop new drugs or to enhance the properties of the existing ones [9,[49][50][51]. After decades, in the context of antimicrobial resistance this is more necessary than ever [9].…”

New Bioactive Co(II) and Ni(II) Complexes with Ofloxacin Mixed-Ligand

“…Their coordination ability is determined by their structural features, namely a planar heteroaromatic system with two nitrogen atoms which permit the formation of a chelate with the metal ion [9,10]. The literature comprises papers in which phen and bipy are used as coligand in the obtaining of metal complexes which have applications in chemistry, biology and medicine [11][12][13][14][15][16][17][18][19][20][21].…”