Complex Acetylenes from the Roots of<i>Ferula communis</i>

Teresa, J. De Pascual; Villaseco, M. A.; Hernández, Javier; Morán, Joaquı́n R.; Urones, Julio G.; Grande, M.

doi:10.1055/s-2007-969253

Cited by 9 publications

(2 citation statements)

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“…The genus Ferula is chemically characterized by volatile oils, sesquiterpenes (Fraga, 1989), sesquiterpene lactones (Holub and Budesinsky, 1986), acetophenone derivatives (Appendino et al, 1989), coumarins (Murray et al, 1982), acetylenes (Teresa et al, 1986), and polysulfanes (Caglioti et al, 1958;Mahran et al, 1975;Trease and Evans, 1983;Zhi-da et al, 1987;Kajimoto et al, 1989). The first study on sulfur compounds in the volatile oil of Ferula was reported by Caglioti et al (1958).…”

Section: Introductionmentioning

confidence: 99%

New Sulfides from Ferula rutabensis

Alsaid

Sattar

El‐Feraly

et al. 1996

International Journal of Pharmacognosy

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Section: Introductionmentioning

confidence: 99%

New Sulfides from Ferula rutabensis

Alsaid

Sattar

El‐Feraly

et al. 1996

International Journal of Pharmacognosy

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“…It is also used as a deodorant. Previous investigations of the chemical composition of Ferula have identified essential oils, flavonoids, minerals, and ferulic acid in the extract [2]. Most reports of Ferula have concentrated on the pharmacological aspects of these compounds.…”

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Polysaccharides from Ferula sinkiangensis and Potent Inhibition of Protein Tyrosine Phosphatase 1B

et al. 2014

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Ferula sinkiangensis is known as a medicinal plant for thousands of years in China. It is a perennial plant species endemic in Xinjiang and is used in traditional Uyghur medicine for a long time >1@. There are many reports on the pharmacological activities of Ferula, which include treating dysentery, counteracting toxins killing parasitic worms, and resolving phlegm. It is also used as a deodorant. Previous investigations of the chemical composition of Ferula have identified essential oils, flavonoids, minerals, and ferulic acid in the extract [2]. Most reports of Ferula have concentrated on the pharmacological aspects of these compounds. Only a few reports have described methods for the extraction of the polysaccharides, and none has described the isolation or identification of these compounds. To the best of our knowledge, there is no report about polysaccharides from roots of Ferula.This study will provide a basis for future research and application of these polysaccharides.The goal of the current work was to establish a method to isolate and quantitate the polysaccharides from roots of Ferula, as well as to determine their monosaccharide compositions, elucidate their structures, and evaluate water-soluble polysaccharides (FSPs), a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) in vitro.Lipids, pigments, and low-molecular-weight compounds were removed from air-dried raw material by extraction with petroleum ether, CHCl 3 , and MeOH [3]. The remaining raw material was dried and then extracted with hot water to obtain FSPs. The yield was 9.5%.The total sugar and protein were measured by anthrone-sulfuric acid and Bradford methods [4,5] with D-glucose and bovine serum albumin (BSA) as standard. The analysis of total sugar and protein contents indicated that FSPs was composed of 45.1 r 3% polysaccharide and 12.5 r 3% protein. Furthermore, uronic acid measurement by the m-hydroxydiphenol method [6] with D-galacturonic acid as standard indicated that 28.1 r 3% of the polysaccharide moiety in FSPs was acidic. Consequently, the preliminary results demonstrated that FSPs was an acid proteoglycan.After removing proteins by the Savage method [7], the crude polysaccharides (FSPs) gave a negative response to the Bradford test, and no absorption was detected at 280 and 260 nm, indicating the absence of protein and nucleic acids.The neutral polysaccharide, eluted with distilled water, was named FSPs-n. The acidic polysaccharides, eluted by the stepwise addition of 0-1.0 M NaCl solutions, was named FSPs-a. The yields of the two fractions were 6.8 and 14.8% in the crude polysaccharides [8,9].According to the results of HPLC analysis [10,11], the carbohydrate portion of FSPs contained ribose, arabinose, glucose, fucose, and galactose in a ratio of 8.9:3.3:2.1:1.5:0.3. FSPs-n was composed of glucose, xylose, arabinose, galactose, and mannose in a ratio of 3.9:4.0:1.8:1.4:0.8, and FSPs-a contained glucose, xylose, mannose, and arabinose in a ratio of 6.5:4.0:1.7:1.0. Furthermore, FSPs and FSPs-a were composed of gluc...

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Umbelliferae

Hegnauer

1990

Chemotaxonomie Der Pflanzen

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Complex Acetylenes from the Roots ofFerula communis

Cited by 9 publications

References 5 publications

New Sulfides from Ferula rutabensis

New Sulfides from Ferula rutabensis

Polysaccharides from Ferula sinkiangensis and Potent Inhibition of Protein Tyrosine Phosphatase 1B

Umbelliferae

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