Complete resolution of cutaneous larva migrans with topical ivermectin: A case report

Magri, Francesca; Chello, Camilla; Pranteda, Guglielmo

doi:10.1111/dth.12845

Cited by 11 publications

(16 citation statements)

References 4 publications

(7 reference statements)

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“…Albendazole shows a potent antiparasitic effect against helminth infection (14). Topical treatment is gradually becoming more popular due to reported side effects of oral preparation (9,11). Thus, topical application…”

Section: Discussionmentioning

confidence: 99%

“…Thus, topical treatments, especially in localized lesions, have been advocated since 2016 and are associated with excellent improvement and minimal systemic side effects (3,6,12). Topical ivermectin, albendazole, and thiabendazole are commonly used topical treatment (6,9,13). Unfortunately, such topical treatments are not always readily available, as is the case in our centre.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Oral ivermectin and albendazole are the first-line treatment with excellent clinical response (9,10). However, both are associated with gastrointestinal side effects and allergic reaction (9,11). Thus, topical treatments, especially in localized lesions, have been advocated since 2016 and are associated with excellent improvement and minimal systemic side effects (3,6,12).…”

Section: Introductionmentioning

confidence: 99%

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Office-made 4% Albendazole Cream is an Effective Alternative Therapy for Cutaneous Larva Migrans: A Report of Three Cases

Mulia

Djawad

Adriani

et al. 2020

Serbian Journal of Dermatology and Venereology

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Introduction. Cutaneous larva migrans (CLM), commonly called creeping eruption, is a parasitic skin disorder caused by the invasion of larva to the skin. This disease classically presents as serpiginous lesions. Larva frequently originates from fecal material of cats and dogs. The pruritus is usually intense and if not treated might disrupt activity, lead to secondary infection, and extend to other regions. Oral and topical antihelminthic agents are the first-line treatment with excellent clinical response. However, they are not always readily available, as is it the case in our region. We attempt to tackle this limitation by formulating an office-made albendazole cream. This report shows the clinical efficacy of our regimen in three cases of CLM.Case Report. We report three cases of CLM diagnosed through history taking and clinical presentation. All cases were treated with topical office-made albendazole as requested by the patients and due to resource limitation. The topical preparation was made by dissolving 400 mg albendazole tablet into sterile water and mixing it with Vaseline to form 4% cream. Three times daily application for seven days led to excellent clinical response.Conclusion. Our 4% office-made albendazole cream was shown to be effective in treating CLM. Thus, this simple and practical preparation may serve as an alternative treatment for CLM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Office-made 4% Albendazole Cream is an Effective Alternative Therapy for Cutaneous Larva Migrans: A Report of Three Cases

Mulia

Djawad

Adriani

et al. 2020

Serbian Journal of Dermatology and Venereology

View full text Add to dashboard Cite

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“…After 2 weeks, their patient experienced complete remission. Successful treatment of CLM with topical ivermectin 1% cream was documented in additional patients with local application twice daily but different duration of treatment, between 3 days and 1 month . In contrast, treatment of CLM with topical ivermectin was found to be ineffective in one study by Veraldi and coworkers on 14 patients including two children with CLM treated with topical ivermectin 1% cream under occlusion with plaster twice daily for two weeks, since complete remission was only observed in one child …”

mentioning

confidence: 99%