Complete Arterial Revascularization With the Internal Thoracic Arteries

Dion, Robert

doi:10.1016/s1085-5637(07)70049-9

Cited by 18 publications

(12 citation statements)

References 38 publications

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“…Previous studies demonstrated that patency rates of bypass grafts might be lower when the bypass conduit was used as an aorto-coronary fashion than when it was used as a composite graft based on the LITA 78. Contradictory results also existed that the patency of the radial artery (RA) was lower when it was used as a composite graft based on the LITA compared to aorto-coronary grafts 2324.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a composite grafting strategy based on the in situ LITA enables an-aortic off-pump CABG in which the risk of stroke could be minimized 6. A previous study showed that the patency of the grafts, even that of the internal thoracic artery (ITA), decreased when they were used as an aorto-coronary fashion 7. A recent randomized controlled trial showed that the patency of the saphenous vein (SV) improved and was non-inferior to that of the right ITA when it was used as a composite graft based on the in situ LITA 8.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry

Kim

Jang

et al. 2019

J Korean Med Sci

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Background The left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes. However, no studies have examined substances other than nitric oxide that could be beneficial for the bypass conduit, native coronary artery or ischemic myocardium. This study was conducted to evaluate differences in metabolic profiles between the LITA and ascending aorta using gas chromatography-time of flight-mass spectrometry (GC-TOF-MS). Methods Twenty patients who underwent CABG using the LITA were prospectively enrolled. Plasma samples were collected simultaneously from the LITA and ascending aorta. GC-TOF-MS based untargeted metabolomic analyses were performed and a 2-step volcano plot analysis was used to identify distinguishable markers from two plasma metabolome profiles. Semi-quantitative and quantitative analyses were performed using GC-TOF-MS and enzyme-linked immunosorbent assay, respectively, after selecting target metabolites based on the metabolite set enrichment analysis. Results Initial volcano plot analysis demonstrated 5 possible markers among 851 peaks detected. The final analysis demonstrated that the L-cysteine peak was significantly higher in the LITA than in the ascending aorta (fold change = 1.86). The concentrations of intermediate metabolites such as L-cysteine, L-methionine and L-cystine in the ‘cysteine and methionine metabolism pathway' were significantly higher in the LITA than in the ascending aorta (2.0-, 1.4- and 1.2-fold, respectively). Quantitative analysis showed that the concentration of hydrogen sulfide (H 2 S) was significantly higher in the LITA. Conclusion The plasma metabolome profiles of the LITA and ascending aorta were different, particularly higher plasma concentrations of L-cysteine and H 2 S in the LITA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry

Kim

Jang

et al. 2019

J Korean Med Sci

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“…The BITA were harvested and grafted as previously described. [4][5] Operative characteristics are detailed in Table 3.…”

Section: Patientsmentioning

confidence: 99%

Comparison of Bilateral Internal Thoracic Artery Revascularization Using In Situ or Y Graft Configurations

Glineur¹,

Hanet²,

Poncelet³

et al. 2008

Circulation

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Background-Bilateral internal thoracic arteries (BITA) demonstrated superiority over other grafts to the left coronary system in terms of patency and survival benefit. Several BITA configurations are proposed for left-sided myocardial revascularization, but the ideal BITA assemblage is still unidentified. Methods and Results-From 03/2003 to 08/2006, 1297 consecutive patients underwent isolated bypass surgery in our institution. 481 patients met the inclusion criteria for randomization, and 304 (64%) were randomized. Patients were allocated to BITA in situ grafting (nϭ147) or Y configuration (nϭ152) then evaluated for clinical, functional, and angiographic outcome after 6 months and 3 years. Patient telephone interviews were conducted every 3 months and a stress test performed twice yearly under the referring cardiologist's supervision. Angiographic follow-up was performed 6 months after surgery. The primary and secondary end points were, respectively, major adverse cerebrocardiovascular events (MACCE) and the proportion of ITA grafts that were completely occluded at follow-up angiography. More arterial anastomoses were performed in patients randomized to the Y than the in situ configuration (3.2 versus 2.4; PϽ0.001). No significant difference between the 2 groups in terms of hospital mortality or morbidity was found. At follow-up, there was no significant difference in any MACCE rate between the 2 groups. 450 out of 464 anastomosis (97%) in the BITA Y group and 287 of 295 (97%) in the BITA in situ group were controlled patent (Pϭ0.99). Conclusion-Excellent patency rates were achieved using both BITA configurations with no significant differences in terms of MACCE up to 19 months postoperatively, but longer-term results remain to be established.

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“…The aim of the present study was, therefore, to investigate, whether a slight modification of the ITA-harvesting procedure might modify endothelial function of the graft. In the conventional harvesting technique the ITA is carefully prepared in a pedicle from the chest wall and finally, after heparinization, the ITA is clipped and dissected at its distal end, wrapped in a papaverine cloth and stored underneath the sternum until its implantation [10]. The advantage of this procedure is an immediate information for the surgeon about the quality of European Journal of Cardio-thoracic Surgery 23 (2003) 956-961 www.elsevier.com/locate/ejcts the vessel concerning its inner diameter and flow.…”

Section: Introductionmentioning

confidence: 99%

Improved endothelial function after a modified harvesting technique of the internal thoracic artery

Grapow¹

2003

European Journal of Cardio-Thoracic Surgery

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Complete Arterial Revascularization With the Internal Thoracic Arteries

Cited by 18 publications

References 38 publications

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry

Comparison of Bilateral Internal Thoracic Artery Revascularization Using In Situ or Y Graft Configurations

Improved endothelial function after a modified harvesting technique of the internal thoracic artery

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