“…The regions identified from gp46 were 20-49, 89-115, 136-160, 175-199, 213-236, 235-254, and 277-292 [30]. Central residues 190-209 have also been shown to induce complement-mediated cytotoxicity [31]. In addition to mapping additional epitopes corresponding to residues 213-236 and 288-317 with mAbs derived from HAM/TSP patients, Baba et al, fine mapped within aa 175-199 to four distinct epitopes: 187-193, 191-196, 193-199, and a continuous conformational epitope that required the entire region for reactivity.…”