Human Leukocyte Antigen Concordance and the Transmission Risk via Breast‐Feeding of Human T Cell Lymphotropic Virus Type I

Biggar, Robert J.; Ng, Jennifer; Kim, Norma; Hisada, Michie; Li, Hong-Chuan; Cranston, Beverly; Hanchard, B; Maloney, Elizabeth M.

doi:10.1086/498910

Cited by 62 publications

(41 citation statements)

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“…Indeed, Biggar et al noted that concordance in HLA class I alleles between a mother and her infant was a strong risk factor for transmission by breast feeding. 13 Specifically, among infants who were breast fed for at least 12 months, HTLV-I infection occurred in 14% of those who differed from their mother at all 3 alleles (HLA-A, B and C), 16% of those who differed at 2 alleles and 38% of those who differed at 0 or 1 allele. 13 All participants in the current analysis were infected with HTLV-I, primarily a consequence of breast feeding during infancy or sexual activity as an adult.…”

Section: Discussionmentioning

confidence: 99%

“…13 Specifically, among infants who were breast fed for at least 12 months, HTLV-I infection occurred in 14% of those who differed from their mother at all 3 alleles (HLA-A, B and C), 16% of those who differed at 2 alleles and 38% of those who differed at 0 or 1 allele. 13 All participants in the current analysis were infected with HTLV-I, primarily a consequence of breast feeding during infancy or sexual activity as an adult. 1 Although HLA may play a weaker role in controlling established infection than it does in preventing infection, we observed that HTLV-I proviral load, which is a major determinant of ATL and HAM/TSP risk, tended to be higher among our asymptomatic carriers who had common HLA B alleles.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 HTLV-I is transmitted primarily by cell-to-cell contact, 11 and transmission from mother to infant is directly related to burden of infection in the mother (proviral load) 12 and is significantly increased for mothers and infants who are highly HLA concordant. 13 In the present study, we examined HLA gene polymorphisms of 305 Jamaican subjects with HTLV-I infection, postulating that people with higher prevalence HLA types may develop an immune response against a narrower range of cell-associated viral or neoplastic antigens and consequently may be at higher risk of ATL or HAM/TSP.…”

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confidence: 99%

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Risk of human T‐lymphotropic virus type I‐associated diseases in Jamaica with common HLA types

Goedert

Gao

et al. 2007

Intl Journal of Cancer

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Human T‐lymphotropic virus‐I (HTLV‐I) causes adult T‐cell leukemia/lymphoma (ATL) and HTLV‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class‐I (A,B) and class‐II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population‐based, asymptomatic HTLV‐I‐infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV‐I proviral load between asymptomatic carriers with common versus uncommon types was compared by t‐test. ATL differed from asymptomatic carriers in overall DQB1 allele and class‐I haplotype frequencies (p ≤≤ 0.04). ATL risk was increased significantly with common HLA‐B (OR 2.25, 95% CI 1.19–4.25) and DRB1 (OR 2.11, 95% CI 1.13–3.40) alleles. Higher prevalence HLA‐B alleles were associated with higher ATL risk (OR 1.14 per quartile, ptrend = 0.02). Asymptomatic carriers with common HLA‐B alleles had marginally higher HTLV‐I proviral load (p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA‐B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma. © 2007 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Risk of human T‐lymphotropic virus type I‐associated diseases in Jamaica with common HLA types

Goedert

Gao

et al. 2007

Intl Journal of Cancer

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“…However, unlike HIV, HTLV-1 is transmitted primarily by cell-to-cell contact rather than by free virus. We reasoned that factors affecting cellular immunity might be more important for the vertical transmission of HTLV-1 than for HIV (Biggar et al 2006). Transmission rates are 16% for children born to infected mothers, 27% for children nursed by infected mothers for more than three months and 5% for children nursed by infected mothers for less than three months (Ureta-Vidal et al 1999).…”

Section: Mother To Childmentioning

confidence: 99%

Human T-Cell Lymphotropic Virus (HTLV-1) and Adult T-Cell Leukemia

Abbaszadegan¹,

Gholamin²

2011

T-Cell Leukemia

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“…Transmission efficiency through the mother to child route is estimated to be more than 20% and has been correlated with individual variables, such as the proviral load of HTLV-1, HLA type, as well as duration of breastfeeding [7]. Transmission from mother to child during the intrauterine or peripartum period has been reported to occur in less than 5% of cases [2].…”

Section: Introductionmentioning

confidence: 99%

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

Ms¹,

Cf²,

G³

et al. 2014

Trop Med Surg

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Objective: Although HTLV-1 is associated with severe diseases, there is ongoing vertical transmission since prenatal HTLV screening is not implemented in countries where the virus is present. We performed a cross-sectional analysis to verify the impact of counseling pregnant HTLV-1 seropositive women, who participate in the GIPH cohort study in Brazil, on this vertical transmission.Methods: GIPH study started in 1997 as an open prevalent cohort of HTLV-positive individuals. Children born from HTLV-1 seropositive women were divided into: (1) born before and (2) after the participation of mothers in the GIPH cohort ("GIPH babies"). The pregnant women participating in the study were counseled in order to prevent viral transmission, with recommendations of avoiding breastfeeding, giving infant formula, and preferably having the delivery by cesarean section. Results:We identified 54 children born of HTLV seropositive mothers. 3/21 (14.3%) of the children born from mothers who received no counseling were found positive for HTLV-1, in contrast to 1/18 (5.6%) of the "GIPH babies", whose mothers received counseling. 15 children were not tested, either due to the family's refusal or impossibility to locate them. Discussion:We found that it was worthwhile to counsel the mothers, since, as previously reported in the literature, we could observe a decline in the vertical transmission, which demonstrates the importance of prenatal screening of the virus. These actions should be widespread in countries where HTLV is present, in order to avoid the silent transmission of HTLV and future diseases in children born from positive mothers.

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Human Leukocyte Antigen Concordance and the Transmission Risk via Breast‐Feeding of Human T Cell Lymphotropic Virus Type I

Cited by 62 publications

References 21 publications

Risk of human T‐lymphotropic virus type I‐associated diseases in Jamaica with common HLA types

Risk of human T‐lymphotropic virus type I‐associated diseases in Jamaica with common HLA types

Human T-Cell Lymphotropic Virus (HTLV-1) and Adult T-Cell Leukemia

Vertical Transmission of Human T-Cell Lymphothropic Virus Type 1: Impact of Counseling Seropositive Women

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