Compensatory renal growth: Interactions of nephrectomy serum and urine antisera leading to a new theory of renal growth regulation

Snow, Brent W.; Tarry, William F.; Duckett, John W.

doi:10.1007/bf00256326

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…The great variability in DNA synthesis-stimulating activity levels exhibited by serum samples in different cell types shown in that study make it difficult for conclusions to be drawn as to the specificity of serum renotropic factor(s). The interpretation of data assessing the renotropic activity in unextracted plasma are complicated due to the presence in plasma of a variety of regulators (activators and inhibi tors) of renal growth [17][18][19][20], In fact, we observed a broad range of activity values in our subjects' plasma when using plasma concentrations of less than 30% in our tubule assay. These values though were lower than those previously reported by using human kidney cells in the bioassay of plasma [15], suggesting a certain species-specificity of the renotropic activity.…”

Section: Discussionmentioning

confidence: 89%

Partial Purification of a Renotropic Activity from Plasma of Uninephrectomized Human Subjects

Garcı́a-Ocaña

Ortega²,

González‐García³

et al. 1993

Nephron

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A renotropic factor was partially purified by sequential gel filtration and anion exchanger chromatography from plasma of human kidney transplantation donors and a renal cancer patient after uninephrectomy. This activity increased the rate of [³H]thymidine incorporation into DNA in rat cortical tubules, but not in rat liver cells, within the range of 100-200 ng/ml protein. The renotropic activity was detected between 7 and 12 days after uninephrectomy, and at least in 1 case decreased thereafter. This activity was undetected in gel-filtrated plasma of patients after a nonurological surgical procedure. The potency of this renotropic activity and its elution by gel filtration are similar to those displayed by a renal growth factor activity isolated from uninephrectomized rat plasma, as recently reported.

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Section: Discussionmentioning

confidence: 89%

Partial Purification of a Renotropic Activity from Plasma of Uninephrectomized Human Subjects

Garcı́a-Ocaña

Ortega²,

González‐García³

et al. 1993

Nephron

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“…Such a regenerative event occurs predominantly in cortico-medullar tubular cells at S3-segments. Humoral factors (i.e., "renotropine") are involved in renal growth after nephrectomy (37). In rats that underwent left nephrectomy, HGF mRNA and protein levels in the kidney and other intact organs (such as lungs and spleen) rapidly increased (38,39), followed by hyperplasia in tubular cells.…”

Section: Renotrophic Role In Acute Renal Injuriesmentioning

confidence: 99%

HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease

Mizuno¹

2008

Front Biosci

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Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target cell type. During the earlier stages of chronic renal failure, renal HGF expression increased, but in later stages HGF expression decreased, associated with manifestation of chronic renal failure. When anti-HGF IgG was administered into mice with chronic renal failure, renal dysfunction and fibrosis were accelerated, indicating a role of endogenous HGF to suppress chronic renal failure. For myofibroblasts, a key cell type in tissue fibrosis, HGF exerted biological activities, including (i) inhibition of growth, (ii) suppression of fibrogenic cytokine expression, and (iii) enhancement of matrix metalloproteinases involved in subsequent apoptosis. In models of glomerular and tubulo-interstitial fibrosis, administration of HGF or HGF gene therapy improved renal fibrosis and dysfunction. Since insufficient production of HGF is causative for renal fibrosis, supplementation with HGF represents a new approach to inhibit or improve chronic renal failure.

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“…1988, Montreal. Canada. sitivity to allow further characterization of the renotropic activity since the possible existence of circulating inhibitors of renal growth might interfere with such an activity [4,5], By using chromatographic techniques, we recently partially purified a renal growth factor activity from plasma of uninephrectomized rats [6]. This activity was found to increase, dose-dependently, ( 'U)thymidine incorpora tion into mouse kidney DNA in vivo as well as into DNA of LLC-PKi cells in vitro.…”

Section: Introductionmentioning

confidence: 99%

Biological Properties of a Renotropic Protein Present in Plasma of Uninephrectomized Rats

Esbrit

Garcı́a-Ocaña²,

García-Cañero³

et al. 1991

Kidney Blood Press Res

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The biological characteristics of a kidney growth factor (KGF) from uninephrectomized rat plasma have been studied. A crude preparation of this factor [Nephrol. Dial. Transplant. 4: 334–338,1989] was further purified by hydrophobic interaction HPLC and gel filtration. KGF was found to be a heat- and trypsin-resistant protein. This factor stimulated dose-depend-ently DNA synthesis by the mouse kidney in vivo, and by either rat renal tubules or serum-deprived LLC-PK₁ cells, in vitro. KGF also increased protein synthesis in these cells, in a dose-dependent manner. Moreover, KGF stimulated sodium uptake by these cells, associated with the maximal increase of protein synthesis. Our findings indicate that KGF is a potent renotropic protein which can play a key role in the renal compensatory growth after uninephrectomy.

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Compensatory renal growth: Interactions of nephrectomy serum and urine antisera leading to a new theory of renal growth regulation

Cited by 5 publications

References 12 publications

Partial Purification of a Renotropic Activity from Plasma of Uninephrectomized Human Subjects

Partial Purification of a Renotropic Activity from Plasma of Uninephrectomized Human Subjects

HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease

Biological Properties of a Renotropic Protein Present in Plasma of Uninephrectomized Rats

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