HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease

Mizuno, Shinya

doi:10.2741/3211

Cited by 62 publications

(63 citation statements)

References 85 publications

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“…BT-474 cells express the c-Met receptor, whereas ZR-75-1 cells do not. Because activation of the c-Met receptor by HGF reduces fibrosis (36,37), HGF signaling through the c-Met receptor may be responsible for the decreased total interstitial fibrosis observed in the BT-474 tumors (38,39). On the other hand, HER2 signaling increases the expression of the Wilms' tumor suppressor gene (WT1) product through activation of protein kinase B (Akt; ref.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors

et al. 2010

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Angiotensin-(1-7) ] is an endogenous 7-amino acid peptide hormone of the renin-angiotensin system that has antiproliferative properties. In this study, Ang-(1-7) inhibited the growth of cancer-associated fibroblasts (CAF) and reduced fibrosis in the tumor microenvironment. A marked decrease in tumor volume and weight was observed in orthotopic human breast tumors positive for the estrogen receptor (BT-474 or ZR-75-1) and HER2 (BT-474) following Ang-

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Section: Discussionmentioning

confidence: 99%

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors

et al. 2010

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“…Hepatocyte growth factor (HGF) was initially identified as a mitogen of hepatocytes and promotes the regeneration and repair of the kidney, lung and several other tissues (6)(7)(8). In terms of its clinical application, human HGF plasmid DNA has been used in the treatment of critical limb ischemia (9,10).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of intradiscal hepatocyte growth factor injection for the treatment of intervertebral disc degeneration

Zou

Jiang

et al. 2013

Molecular Medicine Reports

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Abstract.A poor nutritional supply to the cells of the avascular intervertebral discs, caused by dehydration of the extracellular matrix, is a major cause of intervertebral disc degeneration (IDD). Since hepatocyte growth factor (HGF) has been shown to exert antifibrotic effects, we hypothesized that HGF treatment may be capable of retarding IDD. The present study aimed to evaluate the efficacy of HGF treatment in retarding IDD in a rat tail model of disc degeneration. The disc degeneration models were induced by needle puncture of the rat tail discs. Four weeks following needle puncture, a triblock poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide; PLGA-PEG-PLGA) polymer gel loaded with HGF or the gel alone was injected into rat tail discs. The efficacy of HGF in retarding IDD was assessed by magnetic resonance imaging (MRI), histological and immunohistochemical evaluation of the type I collagen, type II collagen and bone morphogenetic protein-2 (BMP-2) expression levels. Following injection of the HGF-loaded gel into the nucleus pulposus (NP), a significant trend towards an increase in T2 signal intensity (P=0.028), type II collagen staining in the NP and the number of BMP-2-positive cells in the annulus fibrosus was observed. In addition, the results demonstrated a significant trend towards a decrease in the histological score (P=0.025) and type I collagen staining in the NP compared with segments treated with the gel alone, following the induction of disc degeneration by stab injury. Following treatment with HGF, a tendency for the level of disc height to be maintained was also observed (no statistical significance). By MRI, histological and immunohistochemical evaluation, the present study demonstrated that HGF-loaded PLGA-PEG-PLGA gel was able to retard disc degeneration when injected into the degenerative discs of rat tail models.

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“…Hepatocyte growth factor (HGF), originally identified and cloned as a potent mitogen for mature hepatocytes [16][17][18] , has mitogenic, morphogenic, and anti-apoptotic activities in a wide variety of cells, preferentially in most epithelial and Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage www.nature.com/aps Hu SY et al Acta Pharmacologica Sinica npg endothelial cells [19][20][21] . It is particularly important that HGF enhances regeneration of organs such as liver, kidney and lung [20] .…”

Section: Introductionmentioning

confidence: 99%

Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage

Duan²,

Li³

et al. 2009

Acta Pharmacol Sin

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Aim: To investigate the effect of HGF on proliferation, apoptosis and migratory ability of human vascular endothelial cells against gamma ray irradiation. Methods: ECV304 cells derived from adult human umbilical vein endothelial cells (HUVEC) were irradiated with a single gamma ray dose of 20 Gy. Immunocytochemistry and Western blot analysis were used to detect c-Met protein expression and HGF/c-Met signal pathway. In the HGF-treated groups, ECV304 cells were incubated with HGF (20 or 40 ng/mL) 3 h prior to irradiation. At 48 h postirradiation, the proliferation of ECV304 cells was measured by MTT assay, the apoptosis was assessed by flow cytometry, and the migratory ability of ECV304 cells was measured by transwell chamber assay. Results: c-Met protein is expressed in ECV304 cells and can be activated by HGF. Gamma ray irradiation inhibits proliferation and migration of ECV304 cells in a dose-dependent manner. HGF significantly promoted the proliferation of ECV304 cells, and flow cytometry revealed that HGF can inhibit apoptosis of ECV304 cells. Transwell chamber assay also showed that HGF increases migration activity of endothelial cells. Conclusion: HGF may afford protection to vascular endothelial cells against gamma ray irradiation-induced damage.

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HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease

Cited by 62 publications

References 85 publications

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors

Efficacy of intradiscal hepatocyte growth factor injection for the treatment of intervertebral disc degeneration

Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage

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