Compatibility Study Between Famotidine and Some Excipients Using Differential Scanning Calorimetry

“…This was verified by a new study with a second heating, it showed a broad melting peak corresponding to the drug changing at a lower temperature with a slight change in associated enthalpy. There are many active ingredients that are incompatible with this excipient for example famotidine [48], quinapril [49] or metronidazole [50].…”

Section: Thermal Analysismentioning

confidence: 99%

Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets

Blasco¹,

Pena-Fernandez

Peña

2020

Pharmaceuticals

View full text Add to dashboard Cite

This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies.

show abstract

“…Solution interaction studies may have some predictive capability because of such possibilities. For example, polyvinylpyrrolidone (PVP or povidone) can interact with compounds containing hydrogen-donating functional groups (3,4).…”

Section: -Hydrogen-donating Interactionsmentioning

confidence: 99%

Basic principles of drug--excipients interactions

Vranić

2004

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Excipients are generally considered inert additives included in drug formulation to help in the manufacturing, administration or absorption. Other reasons for inclusion concern product differentiation, appearance enhancement or retention of quality. Excipients can initiate, propagate or participate in chemical or physical interactions with an active substance, possibly leading to compromised quality or performance of the medication. Understanding the chemical and physical nature of excipients, the impurities or residues associated with them and how they may interact with other materials, or with each other, forewarns the pharmaceutical technologist of possibilities for undesirable developments.

show abstract

Compatibility Study Between Famotidine and Some Excipients Using Differential Scanning Calorimetry

Cited by 13 publications

References 6 publications

Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization

Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization

Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets

Basic principles of drug--excipients interactions

Contact Info

Product

Resources

About