Objectives:To examine the comfort level and survey preferences of participants who completed handheld computer-assisted self-interviews (H-CASI). Methods: Obstetrics patients (N=187) were surveyed about their comfort with the H-CASI and its readability, likeability, ease of use, and preferability over paper-and-pencil surveys. Results: Most participants were comfortable using the handheld computer and stated a preference of H-CASI over paperand-pencil surveys. Previous computer experience and lower education level predicted greater handheld-computer preference. Conclusion: Results suggest that data collection using H-CASI may be an appropriate and preferable strategy for many participants.