Comparison tests for plasma viscosity measurements

Lee, D.H.; Jung, Joon Min; Kim, S.Y.; Kim, K.T.; Cho, Y.I.

doi:10.1016/j.icheatmasstransfer.2012.10.018

Cited by 10 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, quantifying the viscosity of the MNP environment can provide information about nanoparticle binding to or internalization in cells, which would be useful for applications like targeted cancer treatment. Blood viscosity could also be detected as an indication of disease, [ 145 ] such as a brain hemorrhage, during which blood coagulation occurs. [ 146 ] Temperature can be another significant marker of disease; malignant cells have a higher temperature than normal cells, by possibly up to 1 °C, and general inflammation results in temperature changes.…”

Section: Magnetic Particle Imagingmentioning

confidence: 99%

Nonequilibrium Dynamics of Magnetic Nanoparticles with Applications in Biomedicine

2020

View full text Add to dashboard Cite

Magnetic nanoparticles are currently the focus of investigation for a wide range of biomedical applications that fall into the categories of imaging, sensing, and therapeutics. A deep understanding of nanoparticle magnetization dynamics is fundamental to optimization and further development of these applications. Here, a summary of theoretical models of nanoparticle dynamics is presented, and computational nonequilibrium models are outlined, which currently represent the most sophisticated methods for modeling nanoparticle dynamics. Nanoparticle magnetization response is explored in depth; the effect of applied field amplitude, as well as nanoparticle size, on the resulting rotation mechanism and timescale is investigated. Two applications in biomedicine, magnetic particle imaging and magnetic fluid hyperthermia, are highlighted.

show abstract

Section: Magnetic Particle Imagingmentioning

confidence: 99%

Nonequilibrium Dynamics of Magnetic Nanoparticles with Applications in Biomedicine

2020

View full text Add to dashboard Cite

show abstract

“…Blood plasma viscosity can be used for the diagnosis of several diseases such as cardiovascular disorders, rheumatoid arthritis, certain autoimmune diseases [1]. Plasma viscosity increases in parallel with erythrocyte sedimentation rate (ESR), however, it is not influenced by hematocrit (anemia, polycytemia).…”

Section: Introductionmentioning

confidence: 99%

Microcantilever based disposable viscosity sensor for serum and blood plasma measurements

Çakmak

Elbüken

Ermek

et al. 2013

Methods

View full text Add to dashboard Cite

a b s t r a c tThis paper proposes a novel method for measuring blood plasma and serum viscosity with a microcantilever-based MEMS sensor. MEMS cantilevers are made of electroplated nickel and actuated remotely with magnetic field using an electro-coil. Real-time monitoring of cantilever resonant frequency is performed remotely using diffraction gratings fabricated at the tip of the dynamic cantilevers. Only few nanometer cantilever deflection is sufficient due to interferometric sensitivity of the readout. The resonant frequency of the cantilever is tracked with a phase lock loop (PLL) control circuit. The viscosities of liquid samples are obtained through the measurement of the cantilever's frequency change with respect to a reference measurement taken within a liquid of known viscosity. We performed measurements with glycerol solutions at different temperatures and validated the repeatability of the system by comparing with a reference commercial viscometer. Experimental results are compared with the theoretical predictions based on Sader's theory and agreed reasonably well. Afterwards viscosities of different Fetal Bovine Serum and Bovine Serum Albumin mixtures are measured both at 23°C and 37°C, body temperature. Finally the viscosities of human blood plasma samples taken from healthy donors are measured. The proposed method is capable of measuring viscosities from 0.86 cP to 3.02 cP, which covers human blood plasma viscosity range, with a resolution better than 0.04 cP. The sample volume requirement is less than 150 ll and can be reduced significantly with optimized cartridge design. Both the actuation and sensing are carried out remotely, which allows for disposable sensor cartridges.

show abstract

“…The temperature uncertainty is ±0.02 K (k = 2) from 288.15 to 378.15 K. The precision of the dynamic viscosity measurements is ±0.5%. The overall uncertainty of the measurements (taking into account the purity and handling of the samples) is estimated to be 2% [2,[7][8][9].…”

Section: Uhrmentioning

confidence: 99%

Comparison tests for the determination of the viscosity values of reference liquids by capillary viscometers and stabinger viscometer SVM 3001

Sariyerli

Sakarya

Akcadag

2018

Int. J. Metrol. Qual. Eng.

View full text Add to dashboard Cite

The present study was realized for measuring viscosities of reference liquids using capillary viscometers and Stabinger viscometer SVM 3001 with viscosity interval between 1 mm2/s and 5000 mm2/s with temperatures from 20 °C to 80 °C. Based on our measurement with various liquids, we determine the viscosity values and compare both of the results. The aim of this study to evaluate the results of the primary level viscosity measurement system and stabinger viscometer and to compare the measurement results due to the providing traceability of Stabinger viscometer by TUBITAK UME. An increasing number of national metrology institutes and accredited laboratories provide viscometer calibration with reference liquids in a wide viscosity range. It is a common practice to use the viscosity of water as the metrological basic of viscometry. The national standard of viscosity provided by TUBITAK UME consists of a set of ubbelohde viscometers covering the measuring range of kinematic viscosities from about 0.5 mm2/s to 100 000 mm2/s. At the low viscosity, long − capillary viscometers are used as primary standards which are directly calibrated water.

show abstract

Comparison tests for plasma viscosity measurements

Cited by 10 publications

References 25 publications

Nonequilibrium Dynamics of Magnetic Nanoparticles with Applications in Biomedicine

Nonequilibrium Dynamics of Magnetic Nanoparticles with Applications in Biomedicine

Microcantilever based disposable viscosity sensor for serum and blood plasma measurements

Comparison tests for the determination of the viscosity values of reference liquids by capillary viscometers and stabinger viscometer SVM 3001

Contact Info

Product

Resources

About