Comparison study of gut microbiota in case of Parkinson’s disease and other neurological disorders

Алексеевич, Петров Вячеслав; Михайловна, Алифирова Валентина; Владимировна, Салтыкова Ирина; Александровна, Жукова Ирина; Григорьевна, Жукова Наталья; Борисовна, Дорофеева Юлия; Викторович, Тяхт Александр; Алексеевич, Алтухов Илья; Сергеевна, Кострюкова Елена; Андреевна, Титова Марина; Сергеевна, Миронова Юлия; Петровна, Ижболдина Ольга; Анатольевна, Никитина Мария; Владимировна, Перевозчикова Татьяна; Александровна, Файт Елена; Эдуардович, Сазонов Алексей

doi:10.20538/1682-0363-2016-5-113-125

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…Â èññëåäîâàíèå áûëî âêëþ÷åíî 192 ìåòàãåíîìíûõ ïðîôèëÿ êèøå÷íîé ìèêðîáèîòû, ïîëó÷åííûõ â ðåçóëüòàòå àìïëèêîííîãî ñåêâåíèðîâàíèÿ ïî ôðàãìåíòó V3-V4 ãåíà áàêòåðèàëüíîé 16S ðÐÍÊ, êîòîðûå áûëè ïðîàíàëèçèðîâàíû è îïóáëèêîâàíû ðàíåå íàøèì êîëëåêòèâîì [15,16]. Âñå îáðàçöû äåëèëè íà äâå ãðóïïû: ýêñïåðèìåíòàëüíóþ, â êîòîðóþ âîøëî 93 ìåòàãåíîìíûõ ïðîôèëÿ îò ïàöèåíòîâ ñ ïîäòâåðaeäåííûì äèàãíîçîì áîëåçíè Ïàðêèíñîíà, è êîíòðîëüíóþ.…”

Section: материалы и методыunclassified

Diagnostic potential of gut microbiota in Parkinson’s disease

et al. 2020

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Background. Nowadays many efforts are taken in searching for Parkinson’s disease biomarkers, especially for an early recognition of the disease. The gut microbiota is one of the potential sources of biomarkers, changes in the composition of which in PD are actively studied.The aim of this study is to identify microbiota biomarkers in the Parkinson’s disease with an estimated accuracy of the diagnostics, including differential diagnostics, relative to other neurological diseases for patients of the Russian population.Material and methods. One hundred ninety-two metagenomics profiles from patients with Parkinson’s disease (n = 93), people with other neurological diagnoses (n = 33), and healthy controls (n = 66) were included in this study. These profiles were obtained with amplicon sequencing of bacterial 16S rRNA genes. Classifying models were made using the naive Bayes classifier, the artificial neural network, support vector machine, generalized linear model, and partial least squares regression.As a result we established that an optimal classification by the composition of the gut microbiota on the validation sample (sensitivity 91.30%, specificity 91.67% at 91.49% accuracy) amid patients was demonstrated with a naive Bayes classifier using the representation of the following genera as predictors: Christensenella, Methanobrevibacter, Leuconostoc, Enterococcus, Catabacter, Desulfovibrio, Sphingomonas, Yokenella, Atopobium, Fusicatenibacter, Cloacibacillus, Bulleidia, Acetanaerobacterium, and Staphylococcus.Conclusions. Information of the gut microbiota taxonomic composition may be used in differential diagnosis of Parkinson’s disease.

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Section: материалы и методыunclassified

Diagnostic potential of gut microbiota in Parkinson’s disease

et al. 2020

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“…Влияние кишечной микробиоты на организм человека не ограничивается только местом ее Обзоры и лекции непосредственного обитания. В настоящее время появляется все больше исследований о возможной взаимосвязи кишечной микробиоты с хроническими неинфекционными болезнями не только желудочно-кишечного тракта, но и бронхолегочной, нервной и сердечно-сосудистой систем [5,32,33]. В ýкспериментальном исследовании показано, что мыши, лишенные микробиоты кишечника (под воздействием антибактериальных препаратов), имеют повышенный риск развития аллергии [34].…”

Section: исследования микробиоты на фоне воспалительных заболеваний кишечника (клинические данные)unclassified

Helminths and intestinal microbiota interaction: role in the development of noncommunicable diseases

et al. 2019

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There is an increase in the prevalence of chronic, noncommunicable diseases, including allergic and autoimmune diseases in developed countries. In this regard, the study of factors modifying the population’s immune response is very important.According to the “old friends” hypothesis , insufficiency of infectious stimulation and decrease in prevalence of helminthiasis are associated with development of noncommunicable diseases. Studies revealed that intestinal parasites modulate the host immune response and alter susceptibility to immunological diseases. It is suggested that one of the pathogenetic mechanisms of immune response modulation by parasites is an increase in the content of gastrointestinal bacteria with anti-inflammatory effect. Advanced technologies of microorganism identification provide a deep insight into the microbiota in different pathologies. The study of changes in the intestine and bile microbiota of the host in helminthiases provides new possibilities for prevention, diagnosis and control of such conditions as chronic inflammatory bowel diseases and allergic diseases. The purpose of this review is to analyze current experimental and clinical data on intestinal microbiota in helminth infections and possible association with development of chronic noncommunicable diseases.

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“…The microbiome is a dynamic ecological community which mainly includes bacteria, archaea, fungi and viruses [13]. There is growing evidence proving that the microbiome plays key roles in the cancer and neurological disease [14][15][16][17]. During recent years, the potential role of the microbiome in various human diseases has attracted the attention of researchers [13,18].…”

Section: Introductionmentioning

confidence: 99%

Rubidium chloride modulated the fecal microbiota community in mice

Chen

Zhuo

et al. 2021

BMC Microbiol

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Background The microbiota plays an important role in host health. Although rubidium (Rb) has been used to study its effects on depression and cancers, the interaction between microbial commensals and Rb is still unexplored. To gain the knowledge of the relationship between Rb and microbes, 51 mice receiving RbCl-based treatment and 13 untreated mice were evaluated for their characteristics and bacterial microbiome changes. Results The 16S ribosomal RNA gene sequencing of fecal microbiota showed that RbCl generally maintained fecal microbial community diversity, while the shifts in fecal microbial composition were apparent after RbCl exposure. RbCl significantly enhanced the abundances of Rikenellaceae, Alistipes, Clostridium XlVa and sulfate-reducing bacteria including Deltaproteobacteria, Desulfovibrionales, Desulfovibrionaceae and Desulfovibrio, but significantly inhibited the abundances of Tenericutes, Mollicutes, Anaeroplasmatales, Anaeroplasmataceae and Anaeroplasma lineages. With regarding to the archaea, we only observed two less richness archaea Sulfolobus and Acidiplasma at the genus level. Conclusions Changes of fecal microbes may in part contribute to the anticancer or anti-depressant effects of RbCl. These findings further validate that the microbiome could be a target for therapeutic intervention.

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Comparison study of gut microbiota in case of Parkinson’s disease and other neurological disorders

Cited by 12 publications

References 38 publications

Diagnostic potential of gut microbiota in Parkinson’s disease

Diagnostic potential of gut microbiota in Parkinson’s disease

Helminths and intestinal microbiota interaction: role in the development of noncommunicable diseases

Rubidium chloride modulated the fecal microbiota community in mice

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