Comparison platelet indices in diabetic patients with and without diabetic foot ulcer

Mardia, Andri I; Gatot, Dairion; Lindarto, Dharma

doi:10.1088/1755-1315/125/1/012134

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Also, Aktar et al (2016) showed that RDW and PDW levels in patients with infectious diseases were significantly higher than in patients in the non-infectious group [32] . Also, in a study in 2018, it was found that PDW level was significantly higher in patients with diabetic foot infection than in patients without diabetic foot infection [8] . Furthermore, in the present study, RDW level in the septicemia group was higher than in the UTI (p=.001), pneumonia (p=.035), and diabetic foot infection (p=.00) groups.…”

Section: Discussionmentioning

confidence: 93%

“…Common infections in hospitals, requiring serious attention include urinary tract infection (UTI), septicemia, pneumonia, and diabetic foot infection, because serious illnesses are associated with severe complications and mortality [2] . Also, these four groups of infectious diseases are among the most common diseases in different societies [2,7,8] . One of the main concerns of infectious disease physicians is the early diagnosis of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that inflammation and infection affect some blood indices [7,8,14] that could be used by physicians as diagnostic markers in diagnosing infectious diseases, including RDW, PDW, ESR (erythrocyte sedimentation rate), and CRP (C-reactive protein) [15,16] . To diagnose common infections, immune cells are counted, especially neutrophils [17,18] .…”

Section: Introductionmentioning

confidence: 99%

“…To diagnose common infections, immune cells are counted, especially neutrophils [17,18] . These parameters could be estimated and evaluated by a complete blood count [14,15] via a simple blood test, which is usually done routinely at the time of admission for patients, and no more specialized tests are needed [8] . The gold standard approach to diagnosing sepsis is blood culture.…”

Section: Introductionmentioning

confidence: 99%

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Association between Hematology Indices as Early Markers and Urinary Tract Infection, Septicemia, Pneumonia, and Diabetic Foot Infection

Majidpour

Arianpor²,

Fathizadeh³

et al. 2022

IEM

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Backgrounds: Infectious diseases are one of the main leading causes of morbidity and mortality worldwide. Therefore, diagnosis and treatment of infectious diseases are very important. Infection affects some blood indices that could be used as diagnostic markers. Therefore, this study aimed to compare blood parameters in four important and prevalent infectious diseases. Materials & Methods: In this study, 202 out of 892 patients with a final diagnosis of UTI (urinary tract infection), septicemia, pneumonia, or diabetic foot infection were evaluated; they were hospitalized in Rasoul Akram hospital in Iran from August 2017 to February 2018. Patients' demographic and laboratory data, such as RDW (red cell distribution width), PDW (platelet distribution width), RBC (red blood cell), CRP (C-reactive protein), ESR (erythrocyte sedimentation rate), and, WBC (white blood cells), were evaluated. Findings: This study results showed that mortality rate in sepsis cases was higher than in other cases (42.1%). Changes in blood parameters such as RDW, PDW, and EDR levels as well as monocyte, basophil, and eosinophil counts were significant among patients with different infectious diseases, while there was no significant difference in terms of changes in some blood parameters, such as WBC, neutrophil, and lymphocyte counts and CRP level between patients with different infectious diseases. For statistical analysis, one-way ANOVA and LSD post hoc tests were used. Conclusion:According to this study results, it was found that the range of blood parameters varies in different types of infectious diseases. Therefore, the physician could employ routine blood parameters along with other diagnostic factors to more accurately diagnose the type of infection and prescribe more appropriate antibiotics.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between Hematology Indices as Early Markers and Urinary Tract Infection, Septicemia, Pneumonia, and Diabetic Foot Infection

Majidpour

Arianpor²,

Fathizadeh³

et al. 2022

IEM

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“…Mardia et al found a high platelet count, PDW and PCT levels in DM patients with diabetic foot ulcers in contrast to DM patients without diabetic foot ulcers. It indicates that platelets are activated and increased its ability for aggregation (19) . In our ndings Patients with diabetic foot using glimepiride showed high anti thrombotic effect with relatively increased platelet count and deceased indices than patients without complications.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Metformin and Glimepiride on Platelet Count and Indices Among Diabetic Patients Attending Jaber Abu Aliz Diabetic Center in Khartoum State

Hussein

Babikir

Elmagzoub

et al. 2021

Preprint

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BackgroundDiabetes mellitus (DM) is a global pandemic, Platelets have crucial role in accelerated atherosclerosis and thrombosis which characterize DM.AimThe aim of the study was to detect the effect of two major oral hypoglycemic drugs (Metformin and Glimepiride) on platelet count and indices MPV (Mean platelet volume), PLCR (platelet large cell ratio), PDW (platelet distribution width). Beside, to study the effects of variation in Age, sex, duration of the drug, dose of drug, HbA1C level and associated complications.Material and methods96 diabetic patients have been included in this study in addition 50 apparently healthy non-diabetic matching for age and sex subjects have been tested as control group.EDTA anti-coagulated venous blood samples has been taken from each , platelet count and indices were measured using automatic blood counter (Sysmex KX-21N) and HbA1C was Measured using Ichroma II . Statistics was performed by SPSS (version 22). ResultsThe results showed that both types of treatment have reduced platelets indices but the reduction in Glimepiride was insignificant except in PDW when compared with control. Also both have no effect on platelet count. Both treatments have insignificant variation on measured parameters when considering age, gender, dose and treatment duration though significant variation in Glimepiride study population was detected due to associated complications and HbA1C level.ConclusionIt is concluded that both types of drugs reduce platelet indices which have a good prognostic effect on the Pro-thrombotic state and accelerated atherosclerosis which is associated with type 2 Diabetic patients. Metformin have better effect on platelet indices than Glimepiride. Further case control trails are required.

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How important are mean platelet volume and neutrophil values in diabetic foot amputation decision?

Kapukaya

Keklikcioglu

et al. 2021

Eur J Plast Surg

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Comparison platelet indices in diabetic patients with and without diabetic foot ulcer

Cited by 4 publications

References 3 publications

Association between Hematology Indices as Early Markers and Urinary Tract Infection, Septicemia, Pneumonia, and Diabetic Foot Infection

Association between Hematology Indices as Early Markers and Urinary Tract Infection, Septicemia, Pneumonia, and Diabetic Foot Infection

The Effect of Metformin and Glimepiride on Platelet Count and Indices Among Diabetic Patients Attending Jaber Abu Aliz Diabetic Center in Khartoum State

How important are mean platelet volume and neutrophil values in diabetic foot amputation decision?

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