Comparison of vitamin D levels in obese and non obese patients with polycystic ovarian syndrome in a South Indian population

Lakshman, Lakshmi R.; Pillai, Binu Parameswaran; Lakshman, Rahul; Kumar, Harish; Sudha, S.; Jayakumar, RV

doi:10.5455/2320-1770.ijrcog20130915

Cited by 4 publications

(5 citation statements)

References 41 publications

(51 reference statements)

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“…The vitamin D receptor gene regulates approximately 3% of the human genome, including genes that are crucial for glucose and fat metabolism [ 44 ]. A known mechanism that can provide a probable explanation for the favorable effects of vitamin D on serum TG levels is its effect on calcium [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial

et al. 2016

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BACKGROUND/OBJECTIVESVitamin D plays an important role in the etiology of gestational diabetes mellitus (GDM). This study evaluated the effect of vitamin D supplementation on metabolic indices and hs-C-reactive protein (CRP) levels in GDM patients.SUBJECTS/METHODSThe study was a randomized, placebo-controlled, double-blinded clinical trial. Seventy-six pregnant women with GDM and gestational age between 24-28 weeks were assigned to receive four oral treatments consisting of 50,000 IU of vitamin D3 (n = 38) or placebo (n = 38) once every 2 weeks for 2 months. Fasting blood glucose (FG), insulin, HbA1c, 25-hydroxyvitamin D, lipid profile, hs-CRP, and homeostasis model assessment-insulin resistance (HOMA-IR) were measured before and after treatment. Independent and paired t-tests were used to determine intra- and intergroup differences, respectively. ANCOVA was used to assess the effects of vitamin D supplementation on biochemical parameters.RESULTSCompared with the placebo group, in the vitamin D group, the serum level of 25-hydroxyvitamin D increased (19.15 vs. -0.40 ng/ml; P < 0.01) and that of FG (-4.72 vs. 5.27 mg/dl; P = 0.01) as well as HbA1c (-0.18% vs. 0.17%; P = 0.02) decreased. Improvements in the lipid profiles were observed in the vitamin D group, but without statistical significance. Significant increases in concentrations of hs-CRP, FG, HbA1c, total cholesterol, and LDL cholesterol were observed in the placebo group. No significant change in fasting insulin and HOMA-IR was observed in either group.CONCLUSIONSIn GDM patients, vitamin D supplementation improved FG and HbA1c but had no significant effects on lipid profile or hs-CRP.

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Section: Discussionmentioning

confidence: 99%

Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial

et al. 2016

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“…from South India reported low vitamin D levels in both PCOS and control women with mean vitamin D levels15.45±7.88ng/ml and 12.83±5.76ng/ml respectively [14] . In another study, prevalence of vitamin D deficiency was equally common among Korean PCOS women and controls [15] .…”

Section: Discussionmentioning

confidence: 97%

Vitamin D levels in PCOS women and correlation with metabolic parameters

Neelaveni¹,

Himaja²,

Rao³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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Background: PCOS is the common endocrine disorder with reproductive and metabolic dysfunction, which may get adversely affected in association with hypovitaminosis D. we studied vitamin D levels in PCOS women and correlation with metabolic parameters. Materials and Methods: In this cross-sectional study, we enrolled 108 PCOS women, after excluding women, who were on insulin sensitisers, hormone therapy, vitamin D. Detailed history, physical examination findings were noted. Fasting blood sample was analysed for hormonal, biochemical Parameres and OGTT was done as per the standard protocol. Study subjects were categorized based on vitamin D levels into vitamin D deficiency (<20ng/ml), insufficiency (20-30ng/ml), sufficiency (>30ng/ml) groups and were compared for clinical and metabolic parameters using appropriate statistical tests and p< 0.05 was considered statistically significant. Results: study population had a mean age of 24.99±5.07 years with a mean BMI of 28.1±4.67kg/m2. Hypovitaminosis D was found in 85.2% (deficiency in 62.96%, insufficiency in 22.2%) and normal vitamin D levels in 14.8% of the PCOS women. Impaired fasting glucose was found in10.2%, IGT in 15.7% and type2 diabetes in 4.63% women. Triglycerides, LDL-C were significantly higher and HDL-C were lower in women with hypovitaminosis D, with a significant negative correlation with triglycerides and no correlation with other metabolic parameters. Conclusion: vitamin D deficiency is very common in PCOS women and may exacerbate the metabolic disturbances.

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“…There are studies which showed widespread prevalence of vitamin D deficiency in India. [3738] Poor sun exposure due to modern lifestyle, vegetarian diet, skin pigmentation, and cultural practices like parda and burka may be the reasons for this high prevalence in our population. Vitamin D is synthesized when the UV rays from the sun fall on the skin.…”

Section: Discussionmentioning

confidence: 99%

“…Participants were classified as vitamin D deficient, insufficient, and sufficient on the basis of vitamin D concentration of <20 ng/ml, 20-30 ng/ml, and >30 ng/ml, respectively, according to recent consensus. [3738] Vitamin D deficiency can be classified as severe (<10 ng/ml) and mild-moderate deficiency (10-20 ng/ml) depending on the vitamin D levels. [37] The quantitative estimation of 25-OHD 3 is done using ARCHITECT 25-OH assay, which is a Chemiluminescent Microparticle Immuno Assay (CMIA).…”

Section: Methodsmentioning

confidence: 99%

Association between vitamin D and hypertension in people coming for health check up to a tertiary care centre in South India

Vatakencherry

Saraswathy

2019

J Family Med Prim Care

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Background: Recently, there have been a surge in research worldwide regarding relation of vitamin D with several diseases. Many neurological diseases like multiple sclerosis, Alzheimer's disease as well as other diseases like cardiovascular disease have shown positive correlation with vit. D de ciency measured according to the international level. Most of the research on possible role of vitamin D has been carried out in America and European nations, while there is paucity of research in low-and middle-income nations (LMICS) that are nearer to the equatorial area. In countries like Nepal, geographically they lie near to the equator and sunlight exposure is well enough and milk consumption is quite moderate. Thus, special consideration for vitamin D level in Asian population seems plausible. This will not only help us to cover the vitamin D de cient population but will help us to avoid excessive and unnecessary usage of it. Objectives: This study aims to detect the situation of vitamin D in Nepalese population and secondly to nd out the suitable normalized reference range for serum vitamin D in multi-ethnic Nepalese population. Methodology: This was a hospital based prospective study. A prospective study was conducted using purposive sampling technique with in-vivo and in vitro bio-physiological method to collect serum vitamin D level. After rigorous inclusive and exclusive criteria, a total of 107 subjects were collected. Result: The present study showed that 32% of participants had de cit serum Vitamin-D level (<15 ng/mL), 48% of subjects had insu cient serum level of Vitamin-D (15-<30ng/mL) and 20% of participants had su cient serum level of Vitamin-D (>30ng/mL). Study showed that there is lower degree of positive relationship of Body Mass Index (BMI) with Serum Vitamin-D level (r=0.162, p=0.094), History of chronic illness (χ2=0.10, p=0.03), timing of occurrence of stroke (χ2=11.41,p=0.017) and diagnosis (χ2=21.19, p=0.011) had signi cant association with Serum vitamin-D level at p<0.05. Conclusion: There is direct signi cant association of Serum Vitamin D with socio-demographic variables when international unit is considered. Neurological disorder showed positive association with serum vitamin D level.

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Comparison of vitamin D levels in obese and non obese patients with polycystic ovarian syndrome in a South Indian population

Cited by 4 publications

References 41 publications

Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial

Effects of vitamin D supplementation on metabolic indices and hs-CRP levels in gestational diabetes mellitus patients: a randomized, double-blinded, placebo-controlled clinical trial

Vitamin D levels in PCOS women and correlation with metabolic parameters

Association between vitamin D and hypertension in people coming for health check up to a tertiary care centre in South India

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