Association between vitamin D and hypertension in people coming for health check up to a tertiary care centre in South India

Abstract

Background: Recently, there have been a surge in research worldwide regarding relation of vitamin D with several diseases. Many neurological diseases like multiple sclerosis, Alzheimer's disease as well as other diseases like cardiovascular disease have shown positive correlation with vit. D de ciency measured according to the international level. Most of the research on possible role of vitamin D has been carried out in America and European nations, while there is paucity of research in low-and middle-income nations (LMICS) that are nearer to the equatorial area. In countries like Nepal, geographically they lie near to the equator and sunlight exposure is well enough and milk consumption is quite moderate. Thus, special consideration for vitamin D level in Asian population seems plausible. This will not only help us to cover the vitamin D de cient population but will help us to avoid excessive and unnecessary usage of it. Objectives: This study aims to detect the situation of vitamin D in Nepalese population and secondly to nd out the suitable normalized reference range for serum vitamin D in multi-ethnic Nepalese population. Methodology: This was a hospital based prospective study. A prospective study was conducted using purposive sampling technique with in-vivo and in vitro bio-physiological method to collect serum vitamin D level. After rigorous inclusive and exclusive criteria, a total of 107 subjects were collected. Result: The present study showed that 32% of participants had de cit serum Vitamin-D level (<15 ng/mL), 48% of subjects had insu cient serum level of Vitamin-D (15-<30ng/mL) and 20% of participants had su cient serum level of Vitamin-D (>30ng/mL). Study showed that there is lower degree of positive relationship of Body Mass Index (BMI) with Serum Vitamin-D level (r=0.162, p=0.094), History of chronic illness (χ2=0.10, p=0.03), timing of occurrence of stroke (χ2=11.41,p=0.017) and diagnosis (χ2=21.19, p=0.011) had signi cant association with Serum vitamin-D level at p<0.05. Conclusion: There is direct signi cant association of Serum Vitamin D with socio-demographic variables when international unit is considered. Neurological disorder showed positive association with serum vitamin D level.

Prevalence of Vitamin D Deficiency in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study

“…The current investigation found no conclusive evidence of a relationship between hypertension and vitamin D levels (p-value =0.9596). On the contrary, in a study done in a tertiary care center in South India, hypertension was associated with vitamin D deficiency [ 19 ]. However, the current study has only 56 hypertensive participants and 16 participants whose cholesterol levels were deranged.…”

Prevalence of vitamin D deficiency and its association with cardiometabolic risk factors among healthcare workers in the Eastern Cape province, South Africa; cross-sectional study

“…In contrast, an analysis of data from the NHANES III 1988–1994 study showed that low vitamin D was significantly associated with CVDs and select CVD risk factors, including DM, obesity and hypertriglyceridemia 55 . A study conducted in South India demonstrated a strong association between hypertension and vitamin D deficiency 56 . On the other hand, in vivo studies show that low vitamin D levels are associated with increased systolic blood pressure accompanied by an increase in angiotensin 2, which is an important component of blood pressure regulation 55 .…”

Prevalence of Vitamin D deficiency and its association with cardiometabolic risk factors among healthcare workers in the Eastern Cape province, South Africa; Cross-Sectional Study

“…In contrast, an analysis of data from the III 1988-1994 study showed that vitamin D signi cantly associated with CVDs and select CVD risk factors, including DM, obesity and hypertriglyceridemia (50). A study conducted in South India a strong association between hypertension and vitamin D ciency (51). the other hand, in vivo studies show that low vitamin D are associated with increased systolic blood pressure accompanied by an increase in angiotensin 2, which is an important component of blood pressure regulation (50).…”