Comparison of Tropane Alkaloid Spectra Between Datura innoxia Grown in Egypt and Bulgaria

Berkov, Strahil; Zayed, Rawia

doi:10.1515/znc-2004-3-409

Cited by 25 publications

(16 citation statements)

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“…Dans ce travail, le 6-hydroxyatropine (alcaloïde 8) et son dérivé apo le 6-hydroxyapoatropine (alcaloïde 4) sont détectés pour la première fois dans les graines du Datura stramonium L. Ces deux alcaloïdes ont été rapportés dans les graines d'autres espèces de Datura, le Datura ceratocaula (alcaloïdes 4 et 8) [12] et le Datura innoxia (alcaloïde 8) [13].…”

Section: Résultats Cpg/sm Et Discussionunclassified

Détermination des alcaloïdes tropaniques des graines duDatura stramoniumL. par CPG/SM et CL/SM

et al. 2009

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Résumé -Introduction : Datura stramonium L., du nom local Chdeq ej-jmel, est utilisé en médecine traditionnelle marocaine. Matériels et méthodes : L'extrait organique issu des graines sèches réduites en poudre de Datura stramonium L. récoltées dans la région de Kénitra (ouest marocain) a été analysé par chromatographie gazeuse couplée à la spectrométrie de masse. Résultats : L'analyse a permis l'identification de huit alcaloïdes tropaniques, dont le 6-hydroxyatropine et le 6-hydroxyapoatropine qui sont détectés pour la première fois dans les graines de cette espèce. Par ailleurs, les analyses en chromatographie liquide couplée à la spectrométrie de masse ont confirmé que l'atropine et la scopolamine sont les alcaloïdes majoritaires. Discussion et conclusion : Ces deux agents antimuscariniques sont responsables, selon la dose, de sédation ou de délires hallucinatoires recherchés par les usagers. Mots clés : Datura stramonium L., graines, alcaloïdes tropaniques, CPG-SM, CLHP-SM Abstract -Introduction: Datura stramonium L. (Chdeq ej-jmel)is a traditional medicine used in Morocco. Materials and methods: Qualitative analyses of the basic extract of tropane alkaloids in seeds of Datura stramonium L. collected in the region of Kénitra (west of Morroco) were carried out by GC/MS. Results and discussion: Eight tropane alkaloids were identified. Six of these alkaloids were described in previous works, and the other two (6-hydroxyatropine and 6-hydroxyapoatropine) are reported for the first time for this species in the present work. On the other hand, analyses by LC/MS confirmed that atropine and scopolamine are the main tropane alkaloids in seeds of Datura stramonium L. Conclusion: These two drugs are involved in the hallucinogenic and sedative effects of the plant.

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Section: Résultats Cpg/sm Et Discussionunclassified

Détermination des alcaloïdes tropaniques des graines duDatura stramoniumL. par CPG/SM et CL/SM

et al. 2009

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“…tatula, etc.) (Berkov et al, 2006;Berkova and Zayed, 2004). Stems contain more amounts of tropane alkaloid than leaves, flowers, and seeds (Al-yahya and Evans, 1977;Philipov and Berkov, 2002;Lounasmaa and Tamminen, 1993;Vitale et al, 1995).…”

Section: Levels Found In Foods/plantsmentioning

confidence: 99%

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

Dey

Kundu

Kumar

et al. 2020

Recent Advances in Natural Products Analysis

192

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“…as well as berries of Atropa belladonna (deadly nightshade) (Adamse and van Egmond, 2010) and seeds of Hyoscyamus niger (henbane) have been reported as impurities in food (see Section 4.1). For feed materials, five sources of TA contamination were identified by van Kempen (1992), namely D. stramonium, D. ferox, D. metel, D. wrightii and D. inoxia, of which only the first two mentioned species were estimated to occur in relevant quantities in feed materials imported to Europe (Bucher and Meszaros, 1989 (Berkov and Zayed, 2004;Berkov et al, 2006;Doncheva et al, 2006;Philipov et al, 2007). (-)-Hyoscyamine and (-)-scopolamine have also been detected in the flowers of D. suaveolens (syn Brugmansia suaveolens (Hall et al, 1977;Erhardt et al, 2008)).…”

Section: Species Of Relevance For Food and Feedmentioning

confidence: 99%

Scientific Opinion on Tropane alkaloids in food and feed

2013

EFS2

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The European Food Safety Authority (EFSA) was asked to deliver a scientific opinion on the risks to human and animal health related to the presence of tropane alkaloids (TAs) in food and feed. TAs are secondary metabolites which occur in several plant families. Although more than 200 different TAs have been identified in various plants, respective data on toxicity and occurrence in food and feed are limited. Therefore, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) could only perform a risk assessment on (-)-hyoscyamine and (-)-scopolamine, the two TAs for which occurrence and toxicity data were available. Since the pharmacological effects of (-)-hyoscyamine and (-)-scopolamine occur within a short time after administration, the CONTAM Panel concluded that it was appropriate to establish an Acute Reference Dose (ARfD) for these substances. Based on the results for decreased heart rate in a human volunteer study, the CONTAM Panel established a group ARfD of 0.016 µg/kg body weight (b.w.) expressed as the sum of (-)-hyoscyamine and (-)-scopolamine, assuming equivalent potency. Results on TAs in 124 food and 611 feed samples were collected in two Member States. Most of the food and feed samples were left-censored (below limit of detection/limit of quantification). A reliable exposure estimate was only possible for one food and one age class (toddlers). Based on the limited information, the CONTAM Panel concluded that the dietary exposure of toddlers could be up to seven times the group ARfD and could exceed the group ARfD on approximately 11 to 18 % of consumption days. TA toxicosis in livestock and companion animals is relatively rare. © European SUMMARYFollowing a request from the European Commission, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on the risks to human and animal health related to the presence of tropane alkaloids (TA) in food and feed.TAs are secondary metabolites which naturally occur in plants of several families including Brassicaceae, Solanaceae (e.g. mandrake, henbane, deadly nightshade, Jimson weed) and Erythroxylaceae (including coca). The TAs are found in all parts of the plants and are responsible for the toxic effects of some of these plants. TAs contain an azabicyclo[3.2.1]octane ring structure. The common structural element is the tropane skeleton, (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octane. The group of TAs comprises more than 200 compounds and the wide range of compounds occurring especially in the Solanaceae family arises from the esterification of tropine with a variety of acids, such as acetic acid, propanoic acid, isobutyric acid, isovaleric acid, 2-methylbutyric acid, tiglic acid, (+)-α-hydroxy-β-phenylpropionic acid, tropic acid, and atropic acid.Although more than 200 different TAs were so far identified in various plants, respective data on their occurrence in food and feed and on toxicity are limited. The most studied TAs are (-)-hyoscyamine and (-)-scopolamine, which in contrast to the (+...

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Comparison of Tropane Alkaloid Spectra Between Datura innoxia Grown in Egypt and Bulgaria

Cited by 25 publications

References 2 publications

Détermination des alcaloïdes tropaniques des graines duDatura stramoniumL. par CPG/SM et CL/SM

Détermination des alcaloïdes tropaniques des graines duDatura stramoniumL. par CPG/SM et CL/SM

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

Scientific Opinion on Tropane alkaloids in food and feed

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