Comparison of ThinPrep and Conventional Preparations on Fine Needle Aspiration Cytology Material

Dey, Pranab; Luthra, Usha K.; George, Josely; Zuhairy, Fatma; George, Sara S.; Haji, Bahiya I

doi:10.1159/000326224

Cited by 76 publications

(135 citation statements)

References 6 publications

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“…In the present study the cellularity of MLBC smears was initially inferior to CS but after switching from split sampling technique to utilization of a separate pass entirely for MLBC the cellularity of MLBC smears became almost equivalent to CS as was reported by Dey P et al 6 (Table 4). Perez-Reyes et al 19 employed split sampling technique where they divided the aspirate into two halves, one for LBC and the other for CS, hence in their study the cellularity of LBC was inferior to CS.…”

Section: Cellularitysupporting

confidence: 79%

“…17 In addition LBC eliminates the obscuring elements seen in the conventional smears and also provides superior cell preservation. 4,6,17,18 On the other hand, alterations in architecture and cellular morphology as well as loss of informative background are usually seen in FNA smears prepared by LBC. 16,17,19,20,21 In the present study, the age range and mean age was comparable with other studies.…”

Section: Discussionmentioning

confidence: 99%

“…Paraffin embedded H&E stained sections were obtained and studied under light microscopy. In order to standardize the present study the following scoring system 6 was utilized:- …”

Section: Methodsmentioning

confidence: 99%

“…Most of the smears showed better-preserved cells with enhanced nuclear detail, including a more pronounced nucleoli which was also observed by various other authors. 6,16,17 Thus Micheal CW et al, 17 Biscotti CV et al 21 and Feoli F et al 20 observed that in order to avoid diagnostic errors it is advisable to undergo prior training in LBC to understand the morphological changes produced by LBC. Most of the MLBC smears showed cells arranged in monolayered sheets that enabled us to study the cell morphology even better which was also observed by Pawar PS et al 24 In the present study that there was an apparent decrease in number of myoepithelial cells in MLBC smears as compared to CS which was also observed by other authors.…”

Section: Cell Changesmentioning

confidence: 99%

See 3 more Smart Citations

Manual Liquid Based Cytology in Breast Fine Needle Aspiration – Comparison with the Conventional Smear

Mahinderu¹,

Nandini²,

Kishore³

et al. 2016

IOSR

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Section: Cellularitysupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

“…Paraffin embedded H&E stained sections were obtained and studied under light microscopy. In order to standardize the present study the following scoring system 6 was utilized:- …”

Section: Methodsmentioning

confidence: 99%

Section: Cell Changesmentioning

confidence: 99%

See 2 more Smart Citations

Manual Liquid Based Cytology in Breast Fine Needle Aspiration – Comparison with the Conventional Smear

Mahinderu¹,

Nandini²,

Kishore³

et al. 2016

IOSR

View full text Add to dashboard Cite

“…[5][6][7] Occasionally, LBP are the sole preparation when FNA material is scant. In our case, residual material from the FNA was used to prepare the TP.…”

mentioning

confidence: 99%

Fine needle aspiration of meningioma: Cytologic features on ThinPrep

Viswanathan

Sung

Facey

et al. 2017

Diagnostic Cytopathology

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Comparison of ThinPrep and conventional smears in detecting carcinoma in bile duct brushings

Siddiqui

Gokaslan

Saboorian

et al. 2003

Cancer

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BACKGROUND.Bile duct brushing cytology is a common procedure for the exclusion of adenocarcinoma in the bile duct. The authors evaluated the use of ThinPrep (TP) to determine whether the information obtained is equivalent to that found with conventional smear cytology (CS). METHODS.Thirty-eight prospectively collected endoscope retrograde cholangiopancreatography-guided bile duct brushing samples were split in the following manner. First, two to four CS were prepared and immediately spray-fixed or wet-fixed. Second, the remaining sample was rinsed in PreservCyt™ (Cytyc Corp., Boxborough, MA). In the laboratory, one TP slide was prepared from each sample.TP and CS were stained by routine Papanicolaou stain. For the current study, TP and CS were reviewed independently by two cytopathologists. The diagnoses made by the two methods were compared with the final histology. RESULTS.The cytologic diagnoses for both TP and CS were categorized into five main groups: 1) unsatisfactory, 2) negative, 3) reactive, 4) suspicious for malignancy, and 5) malignant. The diagnoses on the 38 TP bile duct brushings and CS were categorized as follows: 1) unsatisfactory-2, 4; 2) negative-7, 4; 3) reactive-10, 14; 4) suspicious for malignancy-9, 9; and 5) malignant-10, 7, respectively. Histologic follow-up was available in 14 cases (reactive-4, suspicious for malignancy-1, and malignant-9). The sensitivity was 77% for TP and 66% for CS. The specificity was 100% for both methods.CONCLUSIONS. The two methods described in the current study detected equivalent disease on bile duct brushings. TP was found to provide better preservation and cytologic detail. However, the diagnostic criteria may require modification. Cancer (Cancer Cytopathol)

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Comparison of ThinPrep and Conventional Preparations on Fine Needle Aspiration Cytology Material

Cited by 76 publications

References 6 publications

Manual Liquid Based Cytology in Breast Fine Needle Aspiration – Comparison with the Conventional Smear

Manual Liquid Based Cytology in Breast Fine Needle Aspiration – Comparison with the Conventional Smear

Fine needle aspiration of meningioma: Cytologic features on ThinPrep

Comparison of ThinPrep and conventional smears in detecting carcinoma in bile duct brushings

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