Comparison of the structure of key variants of microcystin to vasopressin

Gehringer, Michelle M.; Milne, P. J.; Lucietto, F.R.; Downing, Tim G.

doi:10.1016/j.etap.2004.08.006

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…1) are commonly found in freshwater cyanobacteria in China [10]. MCYST-LR was the most toxic followed by [Dha 7 ] MCYST-LR and MCYST-RR [11]. In recent studies, it has been found MCYSTs severely inhibit protein phosphatases 1 (PP-1) and 2A (PP-2A) and have a tumor-promoting activity in the rat liver [12,13].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Microcystins in Rat Plasma by LC–ESI Tandem MS

Dai

Xie

Gao

et al. 2008

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A rapid and sensitive method was developed and validated for the determination of MCYST (microcystin)-RR, -LR, and [Dha 7 ] MCYST-LR in rat plasma by liquid chromatography-tandem mass spectrometry. The analytes were extracted from rat plasma by protein precipitation, followed by solid-phase extraction. Liquid chromatography with electrospray ionization mass spectrometry, operating in selected reaction monitoring (SRM) mode, was used to quantify MCYST-RR, -LR, and [Dha 7 ] MCYST-LR in rat plasma. The recoveries for each analyte in rat plasma ranged from 70.8 to 88.7%. The calibration curve was linear within the range from 0.005 to 1.25 lg mL ] MCYST-LR. The overall precision was determined on three different days. The values for within-and between-day precision in rat plasma were within 15%. This method was applied to the identification and quantification of microcystins in rat plasma with acute exposure of microcystins via intravenous injection.

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Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Microcystins in Rat Plasma by LC–ESI Tandem MS

Dai

Xie

Gao

et al. 2008

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“…The Cyanobacterial Research Group (CRG) at Nelson Mandela Metropolitan University (Port Elizabeth, NMMU) evolved post-2000 based on the need to produce adequate toxin for extensive toxicological studies (Gehringer et al, 2003a:b;Botha et al, 2004a;b;Gehringer et al, 2004;Gehringer et al, 2005). Optimisation of large-scale production and purification of microcystin for these studies required manipulation of environmental conditions.…”

Section: The Cyanobacterial Research Group (Crg)mentioning

confidence: 99%

An overview of cyanobacterial research and management in South Africa post-2000

Harding¹,

Downing

Ginkel³

et al. 2009

WSA

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The quality of South Africa's water resources is becoming increasingly impaired by eutrophication, to the extent that regional crises now prevail. Thirty-five percent of the total storage is eutrophic to hypertrophic -including grosslyenriched reservoirs that far exceed the globally-accepted definition of hypertrophy. Failing infrastructure contributes to the problem of polluted urban runoff which comprises a significant fraction of flows to inland reservoirs, particularly in the landlocked, economic heartland of the country. In the period post-2000, a number of developments have underpinned the provision of a research and management infrastructure that ensures that South African water resource management structures are capable of dealing with cyanobacterial problems. This paper details the progress and achievements that have been made during this period.

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“…The adsorption capacity of the SNMSH to ionic dyes with K o/w and comparison with the other sorbents reported The octanol/water partition coefficient, calculated with the Molinspiration Cheminformatics 37 stable chemical property i.e. lg K o/w ¼ 3.67,42 it is difficult for MC-LR to be removed from drinking water by conventional methods, e.g. flocculation and disinfection.…”

mentioning

confidence: 99%