Comparison of the Incidence of Acute Decompensated Heart Failure Before and After the Major Tsunami in Northeast Japan

Nakamura, Motoyuki; Tanaka, Fumitaka; Nakajima, Shigeru; Honma, Miho; Sakai, Toshiaki; Kawakami, Mikio; Endô, Hiroshi; Onodera, Masayuki; Niiyama, Masanobu; Kubo, Takashi; Sakamaki, Kentaro; Onoda, Toshiyuki; Sakata, Kiyomi; Morino, Yoshihiro; Takahashi, Tomohiro; Makita, Shinji

doi:10.1016/j.amjcard.2012.08.020

Cited by 37 publications

(30 citation statements)

References 10 publications

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“…This suggests that damage caused by the disaster in the study areas was much less serious. In addition, our previous study demonstrated that the incidence of HF in the same area was stable for several months after the disaster [33]. On the basis of these data we believe that any bias induced by the disaster in the incidence of HF regardless of the presence or absence of preserved EF in the present study area may be small.…”

Section: Discussionsupporting

confidence: 61%

Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study

Honma

Tanaka

Sato

et al. 2015

IJC Heart & Vasculature

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BackgroundSex specific temporal trends in the incidence and prevalence of hospitalization for heart failure (HF), particularly in conjunction with reduced and preserved left ventricular ejection fraction (EF) remain unclear, especially in Asian general populations.MethodsWe conducted a community based HF registration study over a 10 year period in an aging cohort of the Japanese general population.ResultsA total of 2598 cases of hospitalized HF were registered during the survey period. Of these 1413 cases (55%) were initial admissions for HF (incident case). The study period was divided into five 2-year terms (T1, 2003–2004; T2, 2005–2006; T3, 2007–2008; T4, 2009–2010; T5, 2011–2012), and data were compared among the terms. Age adjusted incidence of HF (per 105 person-year) remained stable in men, but decreased significantly by 25% in women (from 104 at T1 to 79 at T5; p for trend < 0.05). Among incident cases who underwent echocardiography (≈ 90%), the proportion of HF with preserved EF increased in men (from 32% at T1 to 43% at T5; p for trend < 0.05), and was relatively high and remained stable throughout the study period in women (from 52% at T1 to 58% at T5; p for trend; NS).ConclusionAlthough the incidence of HF has declined especially in women between 2003 and 2012 in the study population, the proportion of HF with preserved EF has increased over time. These trends suggest a future prevalence of HF with preserved EF rather than HF with reduced EF in aging Asian populations.

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Section: Discussionsupporting

confidence: 61%

Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study

Honma

Tanaka

Sato

et al. 2015

IJC Heart & Vasculature

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“…9 Nevertheless, the frequency of acute decompensated heart failure increased in the high flooding area. 8 Therefore, the influence of the disaster on cardio-and cerebrovascular diseases was thought to be mainly due to the degree of destructive damage to the living environment.…”

Section: Strokementioning

confidence: 99%

“…Increases in the incidences of cerebrovascular diseases and pneumonia 7 and acute heart failure 8 were reported after the Great East Japan earthquake. However, the reason for the increase in cerebrovascular diseases after this disaster (ie, whether stress attributable to the quake or stress attributable to tsunami damage, or insufficiency of medical care service increased cerebrovascular attacks) was unclear.…”

mentioning

confidence: 99%

Influence of the Great East Japan Earthquake and Tsunami 2011 on Occurrence of Cerebrovascular Diseases in Iwate, Japan

Omama

Yoshida

Ogasawara

et al. 2013

Stroke

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“…This event was the fourth most powerful earthquake on record and triggered a devastating tsunami. After the disaster, the incidence of cardiovascular and psychiatric diseases increased in the coastal areas of Iwate [1], [2] and Miyagi prefectures [3], [4], and a large-scale population-based biobank, the Tohoku Medical Megabank, was instituted for systematic data collection, storing, and parceling of biological samples, such as serum, plasma, peripheral blood mononuclear cells (PBMCs), and genomic DNA and RNA extracted from PBMCs and urine, as well as heath information (lifestyle, history of illness, and living environment) and gene analysis information, in order to investigate the effects of the earthquake and tsunami on the health of local residents.…”

Section: Introductionmentioning

confidence: 99%

Reduction of Systematic Bias in Transcriptome Data from Human Peripheral Blood Mononuclear Cells for Transportation and Biobanking

et al. 2014

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Transportation of samples is essential for large-scale biobank projects. However, RNA degradation during pre-analytical operations prior to transportation can cause systematic bias in transcriptome data, which may prevent subsequent biomarker identification. Therefore, to collect high-quality biobank samples for expression analysis, specimens must be transported under stable conditions. In this study, we examined the effectiveness of RNA-stabilizing reagents to prevent RNA degradation during pre-analytical operations with an emphasis on RNA from peripheral blood mononuclear cells (PBMCs) to establish a protocol for reducing systematic bias. To this end, we obtained PBMCs from 11 healthy volunteers and analyzed the purity, yield, and integrity of extracted RNA after performing pre-analytical operations for freezing PBMCs at −80°C. We randomly chose 7 samples from 11 samples individually, and systematic bias in expression levels was examined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), RNA sequencing (RNA-Seq) experiments and data analysis. Our data demonstrated that omission of stabilizing reagents significantly lowered RNA integrity, suggesting substantial degradation of RNA molecules due to pre-analytical freezing. qRT-PCR experiments for 19 selected transcripts revealed systematic bias in the expression levels of five transcripts. RNA-Seq for 25,223 transcripts also suggested that about 40% of transcripts were systematically biased. These results indicated that appropriate reduction in systematic bias is essential in protocols for collection of RNA from PBMCs for large-scale biobank projects. Among the seven commercially available stabilizing reagents examined in this study, qRT-PCR and RNA-Seq experiments consistently suggested that RNALock, RNA/DNA Stabilization Reagent for Blood and Bone Marrow, and 1-Thioglycerol/Homogenization solution could reduce systematic bias. On the basis of the results of this study, we established a protocol to reduce systematic bias in the expression levels of RNA transcripts isolated from PBMCs. We believe that these data provide a novel methodology for collection of high-quality RNA from PBMCs for biobank researchers.

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Comparison of the Incidence of Acute Decompensated Heart Failure Before and After the Major Tsunami in Northeast Japan

Cited by 37 publications

References 10 publications

Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study

Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study

Influence of the Great East Japan Earthquake and Tsunami 2011 on Occurrence of Cerebrovascular Diseases in Iwate, Japan

Reduction of Systematic Bias in Transcriptome Data from Human Peripheral Blood Mononuclear Cells for Transportation and Biobanking

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