Sex-specific temporal trends in the incidence and prevalence of hospitalized patients with preserved versus reduced left ventricular ejection fraction heart failure: A Japanese community-wide study

Abstract

BackgroundSex specific temporal trends in the incidence and prevalence of hospitalization for heart failure (HF), particularly in conjunction with reduced and preserved left ventricular ejection fraction (EF) remain unclear, especially in Asian general populations.MethodsWe conducted a community based HF registration study over a 10 year period in an aging cohort of the Japanese general population.ResultsA total of 2598 cases of hospitalized HF were registered during the survey period. Of these 1413 cases (55%) were initial admissions for HF (incident case). The study period was divided into five 2-year terms (T1, 2003–2004; T2, 2005–2006; T3, 2007–2008; T4, 2009–2010; T5, 2011–2012), and data were compared among the terms. Age adjusted incidence of HF (per 105 person-year) remained stable in men, but decreased significantly by 25% in women (from 104 at T1 to 79 at T5; p for trend < 0.05). Among incident cases who underwent echocardiography (≈ 90%), the proportion of HF with preserved EF increased in men (from 32% at T1 to 43% at T5; p for trend < 0.05), and was relatively high and remained stable throughout the study period in women (from 52% at T1 to 58% at T5; p for trend; NS).ConclusionAlthough the incidence of HF has declined especially in women between 2003 and 2012 in the study population, the proportion of HF with preserved EF has increased over time. These trends suggest a future prevalence of HF with preserved EF rather than HF with reduced EF in aging Asian populations.

CHADS2 and modified CHA2DS2‐VASc scores for the prediction of congestive heart failure in patients with nonvalvular atrial fibrillation

“…Risk prediction for the incidence of CHF in patients with AF is especially important since AF is highly associated with CHF in 40% to 60% of Japanese patients [14,15]. Suzuki et al proposed the use of the H2ARDD score (heart disease=2 points, anemia=1 point, renal dysfunction=1 point, diabetes=1 point, and diuretic use=1 point; range 0–6 points) for assessing the risk of CHF in patients with AF [16].…”

Real-World Heart Failure Burden in Thai Patients

“…In contrast, our findings were based on a hospital setting. Furthermore, the observed hospitalization rate was greater than in the Japan study, which was done in six general hospitals during 2003 and 2012; the prevalence rate of HF-related hospitalization varied from 181 to 238 per 100,000 person-years [ 19 ].…”