Comparison of the growth of virulent and attenuated strains of Candida albicans in the kidneys of normal and cortisone-treated mice by Chitin assay

White, Leroy; Gibb, Ellen; Newham, Helen C.; Richardson, Malcolm; Warren, Richard

doi:10.1007/bf00470753

Cited by 7 publications

(1 citation statement)

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“…This greater virulence may reside, in part, in less effective host defence mechanisms against the yeast phase of C. albicans. Differing cell-wall composition between the two growth forms has been reported (Chattaway, Holmes and Barlow, 1968;Braun and Calderone, 1978;White et al, 1979) and may have a bearing on variations in pathogenicity. Although the structure of the cell wall in C. albicans has not yet been fully elucidated, the total thickness of germ-tube walls has been found to be approximately one-half that of the walls of the blastospore (Cassone et al, 1973).…”

Section: Discussionmentioning

confidence: 85%

Tissue responses to the blastospores and hyphae of Candida albicans in the mouse

Evans

1981

Journal of Medical Microbiology

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SUMMARY. Separate groups of mice challenged intravenously with either the blastospore or hyphal forms of the same strain of Candida albicans were examined for comparative mortality rates, organ localisation, and tissue and cellular response to the organisms. Blastospores were more rapidly and consistently fatal to mice than the hyphae. Relatively more hyphal elements than blastospores were initially localised in the lungs but more blastospores than hyphal elements were trapped in the liver. The cells of both forms were more effectively killed in the lungs than in other organs. Blastospores initially found in the kidneys increased rapidly in numbers, but hyphal inocula either grew slowly in the kidneys or were eliminated. After mice were challenged with either hyphae or blastospores the initial inflammatory response in the lungs and liver was predominantly of polymorphonuclear leukocytes, but macrophages were the first inflammatory cells to be seen in kidney sections. Peripheral blood counts showed a leukocytosis in mice of both groups although only blastospores resulted in increased numbers of circulating atypical lymphocytes. The results indicated that lungs may play a more important role than other reticuloendothelial organs in innate resistance to vascular invasion by either of the morphological forms of C. albicans, and macrophages may be crucial to host resistance to renal invasion by this fungus.

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Section: Discussionmentioning

confidence: 85%