Comparison of the efficacy of crude methanolic extracts of Cassia occidentalis and Euphorbia hirta with levamisole-HCL against gastrointestinal nematodes of economic importance to goat production in Uganda

Nsereko, Godfrey; Emudong, Patrick; Omujal, Joseph; Acai, James Okwee; Kungu, Joseph M.; Kabi, Fred; Mugerwa, Swidiq; Bugeza, James

doi:10.1007/s11250-019-01939-6

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…Euphorbia hirta has anthelmintic properties (Nsereko et al, 2019), as well antiinflammatory and anxiolytic effects on neonatal asthmatic rats with inflammation (Xia et al, 2018). Isolated compounds caffeic acid and epicatechin 3-gallate showed antibacterial effect against Pseudomonas aeruginosa (Perumal et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Bayala¹,

Zohoncon²,

Djigma³

et al. 2020

Int. J. Bio. Chem. Sci

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Medicinal plants are a potential source of drug discovery and development of cancer chemoprevention drugs. Thus, the aim of this work was to study the antioxidant and antiproliferative activities of hydromethanolic extracts of Musa sapientum L., Cassia italica (Mill.) Spreng., Crateva adansonii DC., Euphorbia hirta L. and Ceratotheca sesamoides Endl. from Burkina Faso. The antioxidative activity of hydromethanolic extracts of plant was assessed using DPPH radical scavenging assay and ABTS+ radical cation decolorisation assay. Antiproliferative activity was evaluated by MTT assay. Of these five plant extracts, hydromethanolic extract of Euphorbia hirta leaf twigs showed the best antioxidant activity both by DPPH (IC50 = 0.53 ± 0.04 μg extract / μg DPPH) and ABTS (C = 0.302 ± 0.003 μMET / g extract) methods. In addition, hydromethanolic extract of Euphorbia hirta leaf twigs showed the best antiproliferative activity on LNCaP cell lines of prostate cancer while the hydromethanolic extract of the Ceratotheca sesamoides leaf stems showed the best antiproliferative activity on the HeLa cell lines of cervical cancer. This work has shown not only the antioxidant and anticancer activities of these five local plants, but also the potential valorization of these species used in traditional medicine in Burkina Faso.Keywords: Cancer, antioxydant, antiproliferative, Medicinal plants, Burkina Faso.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Bayala¹,

Zohoncon²,

Djigma³

et al. 2020

Int. J. Bio. Chem. Sci

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“…From time immemorial, parts of medicinal plants and their ingredients have been used as primary therapeutic agents in the management of disease conditions [1][2][3] . For centuries, medicinal herbaceous plants including Polygonum chinense L. 4 , Euphorbia hirta L. 5 and Ilex rotunda Thunb 6 have been and are being processed into herbal tea for the management of such disease conditions as dyspepsia, enteritis, gastric ulcer and other digestive system diseases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Ulcerogenic Effects of the Crude Extract and Fractions of Dialium guineense Tree Bark in Ethanol-Induced Peptic Ulcer in Albino Rats

Johnlouis,

Sunday,

Adanma

et al. 2024

Asian J. Biol. Sci

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Background and Objective: Medicinal plants contain bioactive molecules with pharmacological potential for managing diseases. Peptic ulcer is a ravaging disease that has been attributed to cases of mortality across the globe and Dialium guineense; a medicinal plant could form bases for its amelioration hence, this study sets out to evaluate the anti-ulcerogenic potentials of a crude ethanol extract and fractions of Dialium guineense stem bark in ethanol-induced ulcer in albino rats. Materials and Methods:The biochemical effects of Dialium guineense stem bark in ethanol-induced ulcers were determined using standard protocols. The SPSS version 22 was used for the one-way ANOVA analysis (p<0.05). Results: For the gastro-protective estimation, ulcer index and percentage protection score of the treatment groups were significantly (p<0.05) lower than those of the untreated groups and the standard drug (omeprazole) in a dose-dependent manner. There were significant (p<0.05) elevations in red blood cell and hemoglobin concentrations respectively in the groups co-treated with different fractions of Dialium guineense. The result also indicated a significant (p<0.05) decrease in the tumor necrotic factor-α and the interleukin-1β concentration across the fractions group compared with the normal group. The result of the antioxidant study showed significant (p<0.05) increases in the superoxide dismutase, catalase activities and glutathione concentrations of the co-treated groups compared to the untreated group. The organ histology showed protected stomach architecture in the co-treated groups compared to that of the negative control which showed full laceration of the stomach wall. Conclusion:Hence, it could be concluded that different fractions of Dialium guineense stem bark extract have an organo-protective activity which could be attributed to its high antioxidant activity as antioxidants have been found to reverse the toxicity caused by pro-oxidants.

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Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role

Zhou

Yang

Tian

et al. 2020

Biomedicine & Pharmacotherapy

168

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Comparison of the efficacy of crude methanolic extracts of Cassia occidentalis and Euphorbia hirta with levamisole-HCL against gastrointestinal nematodes of economic importance to goat production in Uganda

Cited by 8 publications

References 17 publications

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Evaluation of Anti-Ulcerogenic Effects of the Crude Extract and Fractions of Dialium guineense Tree Bark in Ethanol-Induced Peptic Ulcer in Albino Rats

Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role

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