Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Bayala, Bagora; Zohoncon, Théodora Mahoukèdè; Djigma, Florencia Wendkuuni; Nadembega, Christelle; Baron, Silvère; Lobaccaro, Jean-Marc A.; Simporé, Jacques

doi:10.4314/ijbcs.v14i3.1

Cited by 6 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the extracts of C. papaya and C. nucifera show a moderate effect on the PC-3 lines. According to Bayala et al [38], the cytotoxic effects in this study could be attributed in part to the antioxidant potency of the extracts demonstrated in the previous studies. Indeed, the cytotoxic and anti-proliferative effect of triterpenes, tannins, flavonoids, and saponins highlighted in the extracts has been proven [38] [39].…”

Section: Discussionsupporting

confidence: 62%

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of Carica papaya L. and Cocos nucifera L.

Belem-Kabré¹,

Ouédraogo²,

Bayala³

et al. 2023

AiM

Self Cite

View full text Add to dashboard Cite

Objective: This study focused on the antibacterial and anti-proliferative activity of extracts from Carica papaya and Cocos nucifera roots. Methodology:The minimum inhibitory concentration and the minimum bactericidal concentration of the extracts on Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, and Staphylococcus aureus were deduced by the microdilution method. The anti-biofilm activity was determined on all four strains and anti-quorum sensing activity by inhibition of violacein production in Chromobacterium violaceum. Anti-proliferative activity on prostate cultured cancer cells was evaluated by MTT assay. Sterols and triterpenes were also assayed in this study. Results: The methanolic extract of Carica papaya showed the best anti-biofilm effect with a percentage inhibition of 66.10 ± 1.79. The methanolic extract of Cocos nucifera had the strongest inhibition on the production of quorum sensing (61.42 ± 0.28). In addition, the methanolic extract of Cocos nucifera roots showed the best cytotoxic effect on prostate cancer LNCaP cell lines (IC 50 = 26.98 ± 2.6 μg/mL) and Carica papaya on the PC-3 lines (IC 50 = 127.20 ± 5.99 μg/mL). The extracts were also rich in triterpenes and sterols. Conclusion: This study provides support for How to cite this paper: Belem-Kabré,

show abstract

Section: Discussionsupporting

confidence: 62%

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of Carica papaya L. and Cocos nucifera L.

Belem-Kabré¹,

Ouédraogo²,

Bayala³

et al. 2023

AiM

Self Cite

View full text Add to dashboard Cite

show abstract

“…Despite being a promising anticancer source, hydroethanolic extract of M. sapientum leaves showed no inhibitory effect on LNCap of prostate cancer and HeLa cervical cancer cells with IC 50 > 1000 µg/mL [38].…”

Section: Anticarcinogenic Activitymentioning

confidence: 93%

Musa sapientum L. (banana): potential for drug development

Pereira¹,

Firmo²,

Coutinho³

2022

JBNS

View full text Add to dashboard Cite

Fruits are sources of vitamins, sugars and bioactive compounds associated with reducing the risk of diseases, such as those related to the heart system, gastrointestinal tract, bacterial infections, diabetes, among others. In addition to being widely used in the production of functional foods, in recent years, the pharmaceutical industry has been researching various fruits to be used in the production of medicines. Among the plant species that produce fruits appreciated all over the world, Musa sapientum L., popularly known as banana tree, stands out. The objective of this article was to carry out an integrative review of the scientific literature on the plant species Musa sapientum L. (Musaceae), highlighting its biological properties already demonstrated in pre-clinical tests. The search was carried out in Pubmed, Google Scholar and ScienceDirect databases, using appropriate descriptors and inclusion and exclusion criteria. A total of 735 files were identified, after the screening process, 52 articles were selected and analyzed. The results showed that the fruit of this species has already been extensively studied from the point of view of biological activities, especially antibacterial, antioxidant, antidiabetic, antiinflammatory. The scientific articles analyzed confirm the traditional use of this fruit in the treatment of diseases and that many have already been evaluated through pre-clinical trials. However, no clinical study has ever been conducted with this fruit. Thus, it is concluded that there are numerous proven biological properties for the species M. sapientum, data that can encourage further research, generating more use and elucidating issues that have not yet been clarified for the development of effective and safe drugs.

show abstract

Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

Elshnoudy,

Elkhouly,

Masoud

et al. 2024

Phytochem Rev

View full text Add to dashboard Cite

The increase in cases of various cancers, the number of cancer patients, and the serious side effects of current chemical treatments have encouraged researchers to discover novel and more effective drugs from plant sources. In this review, PubMed and Scopus were searched for English-language peer-reviewed articles published since 1994, using the keywords: Medicinal plants, Egypt, and Cancer. The inclusion criteria for this systematic review were English peer-reviewed original research articles. A total of 286 studies were included. Studies have shown that the active compounds in certain plants can have anticancer activities by various mechanisms, such as cell cycle arrest, apoptosis induction, and antioxidant effects. Additionally, it is evident that medicinal plants can act as inhibitors of cancer cells. Plants can also act as immune checkpoint inhibitors, which inhibit proteins such as PD-L1 on tumor cells, PD-1 and CTLA-4 on T cells, and help to regulate immune responses. This review also discusses the efficacy of nanoparticles of these plants against cancer cells. The findings indicate the high potential of investigating the bioactive anticancer components of Egyptian medicinal plants for advancing novel treatments that are more effective in combating cancer. The extracts and active compounds of the medicinal plants detailed in this review could provide the foundation for further clinical trials to be conducted, to develop new anticancer drugs.

show abstract

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Cited by 6 publications

References 36 publications

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of <i>Carica papaya</i> L. and <i>Cocos nucifera</i> L.

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of <i>Carica papaya</i> L. and <i>Cocos nucifera</i> L.

Musa sapientum L. (banana): potential for drug development

Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

Contact Info

Product

Resources

About

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

Cited by 6 publications

References 36 publications

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of &lt;i&gt;Carica papaya&lt;/i&gt; L. and &lt;i&gt;Cocos nucifera&lt;/i&gt; L.

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of &lt;i&gt;Carica papaya&lt;/i&gt; L. and &lt;i&gt;Cocos nucifera&lt;/i&gt; L.

Musa sapientum L. (banana): potential for drug development

Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

Contact Info

Product

Resources

About

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of <i>Carica papaya</i> L. and <i>Cocos nucifera</i> L.

Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of <i>Carica papaya</i> L. and <i>Cocos nucifera</i> L.