Comparison of the efficacy of subgingival irrigation with 2% povidone-iodine and tetracycline HCl in subjects with chronic moderate periodontitis: A clinico microbiological study

Abstract

Background:This study was performed to evaluate and compare the clinical and antimicrobial efficacy of subgingival irrigation with tetracycline and povidone-iodine as an adjunct to nonsurgical periodontal therapy.Materials and Methods:Twenty subjects with chronic moderate periodontitis were recruited in this split-mouth study with probing pocket depth of >3 and ≤5 mm and clinical attachment loss of 3-4 mm in relation to 16, 36, and 46. In each subject, three selected periodontal pockets were assigned to receive one out of three irrigants (1) sterile water (control) in 16; (2) tetracycline at 10 mg/ml in 36; (3) 2% povidone-iodine in 46, and these sites were designated as Group A, Group B, and Group C, respectively. Plaque score, gingival score, pocket probing depth, and clinical attachment level were evaluated before treatment and at 1 and 3 months posttreatment. Multiplex polymerase chain reaction was used to detect Porphyromonas gingivalis and Tannerella forsythensis which have been implicated as the major risk factors for periodontal disease. Subgingival plaque collected before treatment and at 1 and 3 months posttreatment. Data were analysed using ANOVA and repeated measure ANOVA. Results were considered significant if P < 0.05.Results:Clinical and microbiological parameters were reduced posttreatment, the reduction being significantly higher in Group B compared to Group C.Conclusion:It can be concluded that chemical and mechanical therapies were of slight benefit in the treatment of chronic moderate periodontitis, and there was an adjunctive effect of significance when scaling and root planing was combined with a single subgingival irrigation with tetracycline or povidone-iodine in lower concentration.

Oral Irrigation Devices: A Scoping Review

“…Microbiological outcomes were examined in 58 studies using culture, microscopy, polymerase chain reaction, and sequencing. Few assessed periodontitis patients using molecular biology techniques (Deepa et al 2023 ; Genovesi et al 2013 ; Kshitish and Laxman 2010 ; Perayil et al 2016 ). Overall, oral irrigation reduced pathogens, acidogenic bacteria, anaerobes, spirochetes, and motile rods.…”

“…These findings indicate a potential microbiome‐modulating, host‐response–altering mechanism of oral irrigation. Further research using modern molecular biology techniques is needed to clarify the effects on oral microbiota, especially in periodontitis patients where few such studies exist (Deepa et al 2023 ; Genovesi et al 2013 ; Kshitish and Laxman 2010 ; Perayil et al 2016 ).…”

Effects of Rinsing with Povidone-Iodine during Step II Periodontal Therapy: A Systematic Review and Meta-Analysis

“…Supplement Table S1: Precise search strategy for the three databases (Embase, Cochrane and PubMed) with the boolean parameters used (overview from PubMed). Supplement Table S2: List with excluded studies after full text screening with reason for exclusion [59][60][61][62][63][64][65][66][67]. Supplement Figure S1: Funnel plot of the included studies in the review (in term of probing pocket depth after 6 months).…”

The effect of 1% povidone iodine and 0,75% boric acid on chronic periodontitis treatment

“…Iodine nguyên chất và dẫn xuất của nó là PVP-I được nghiên cứu là một trong những chất có phổ hoạt động rộng và hiệu lực kháng khuẩn cao nhất 5 . Chức năng kháng khuẩn của PVP-I trong hỗ trợ điều trị VNC đã được công nhận qua nhiều nghiên cứu 6,7 . Tuy nhiên, sử dụng PVP-I bị giới hạn trên những bệnh nhân nhạy cảm với iodine, bệnh nhân có bệnh tuyến giáp, bệnh nhân có thai hoặc cho con bú để bảo vệ trẻ sơ sinh 8 thí nghiệm 9 .…”