Comparison of the effects of an intravenous lidocaine infusion combined with 1% isoflurane versus 2% isoflurane alone on selected cardiovascular variables and recovery characteristics during equine general anaesthesia

Benedetti, Inga‐Catalina Cruz; Nottrott, K.; Fourel, Isabelle; Bris, Marjolaine Le; Mongellas, Emilie; Portier, Karine

doi:10.1111/vaa.12376

Cited by 4 publications

(8 citation statements)

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“…Both studies were in horses undergoing magnetic resonance imaging that were anaesthetised three times with isoflurane [310] and six times with sevoflurane [383]. Another study classified as "maintenance with PIVA" also confirmed that the experience gained during previous recoveries may positively affect future recoveries [252].…”

Section: Other Factorsmentioning

confidence: 79%

“…(32) Cardiopulmonary effects and recovery quality of remifentanil-isoflurane anesthesia in horses [247] (33) Clinical comparison of two regimens of lidocaine infusion in horses undergoing laparotomy for colic [248] (34) Effects of medetomidine constant rate infusion on sevoflurane requirement, cardiopulmonary function, and recovery quality in Thoroughbred racehorses undergoing arthroscopic surgery [249] (35) The cardiovascular status of isoflurane-anaesthetized horses with and without dexmedetomidine constant rate infusion evaluated at equivalent depths of anaesthesia [250] (36) Cardiopulmonary effects and anaesthesia recovery quality in horses anaesthetized with isoflurane and low-dose S-ketamine or medetomidine infusions [251] (37) Comparison of the effects of an intravenous lidocaine infusion combined with 1% isoflurane versus 2% isoflurane alone on selected cardiovascular variables and recovery characteristics during equine general anaesthesia [252] (38) Clinical usefulness of intravenous constant rate infusion of fentanyl and medetomidine under sevoflurane anesthesia in Thoroughbred racehorses undergoing internal fixation surgery [253] (39) Effect of detomidine or romifidine constant rate infusion on plasma lactate concentration and inhalant requirements during isoflurane anaesthesia in horses [254] (40) Clinical comparison of dexmedetomidine and medetomidine for isoflurane balanced anaesthesia in horses [255] (41) Clinical evaluation of constant rate infusion of alfaxalone-medetomidine combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery [256] (42) Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery [257] (43) Plasma concentrations at two dexmedetomidine constant rate infusions in isoflurane anaesthetized horses: A clinical study [258] 2 (44) Hemodynamic function during neurectomy in halothane-anesthetized horses with or without constant dose detomidine infusion [259] (45) Combination of continuous intravenous infusion using a mixture of guaifenesin-ketamine-medetomidine and sevoflurane anesthesia in horses [260] (46) Evaluation of a mixture of thiopental-guafinesine-medetomidine and sevoflurane anesthesia in horses [261] (47) Influence of ketamine or xylazine supplementation on isoflurane anaesthetized horses-a controlled clinical trial [262] (48) Comparative study on sevoflurane anesthesia alone and combined with partial intravenous anesthesia using dexmedetomidine in healthy horses [263] 3 (49) Problems associated with perioperative morphine in horses: A retrospective case analysis [264] (50) Recovery quality after romi...…”

Section: Loe Referencesmentioning

confidence: 99%

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Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature

Gozalo-Marcilla

Ringer

2021

Animals

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Recovery remains the most dangerous phase of general anaesthesia in horses. The objective of this publication was to perform a structured literature review including levels of evidence (LoE) of each study with the keywords “recovery anaesthesia horse”, entered at once, in the search browsers PubMed and Web of Science. The two authors independently evaluated each candidate article. A final list with 444 articles was obtained on 5 April 2021, classified as: 41 “narrative reviews/expert opinions”, 16 “retrospective outcome studies”, 5 “surveys”, 59 “premedication/sedation and induction drugs”, 27 “maintenance with inhalant agents”, 55 “maintenance with total intravenous anaesthesia (TIVA)”, 3 “TIVA versus inhalants”, 56 “maintenance with partial intravenous anaesthesia (PIVA)”, 27 “other drugs used during maintenance”, 18 “drugs before/during recovery”, 18 “recovery systems”, 21 “respiratory system in recovery”, 41 “other factors”, 51 “case series/reports” and 6 “systems to score recoveries”. Of them, 167 were LoE 1, 36 LoE 2, 33 LoE 3, 110 LoE 4, 90 LoE 5 and 8 could not be classified based on the available abstract. This review can be used as an up-to-date compilation of the literature about recovery after general anaesthesia in adult horses that tried to minimise the bias inherent to narrative reviews.

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Section: Other Factorsmentioning

confidence: 79%

Section: Loe Referencesmentioning

confidence: 99%

Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature

Gozalo-Marcilla

Ringer

2021

Animals

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“…Since quality of recovery may not be the primary objective in many studies, the ability to make conclusions relating to quality of recovery may be underpowered in some circumstances and should be interpreted with caution. After retrospectively calculating sample sizes, several authors discussed that their studies had been underpowered 21,22 . One of those authors calculated that their sample size, based on differences in mean arterial pressure, would need to be 17 times larger to detect differences in quality of recovery 21 .…”

Section: Resultsmentioning

confidence: 99%

“…After retrospectively calculating sample sizes, several authors discussed that their studies had been underpowered 21,22 . One of those authors calculated that their sample size, based on differences in mean arterial pressure, would need to be 17 times larger to detect differences in quality of recovery 21 . This highlights the limitation that affects many studies of this nature, particularly when the distribution of the data associated with the primary and secondary objectives is different.…”

Section: Resultsmentioning

confidence: 99%

Recovery of horses from general anaesthesia: A systematic review (2000‐2020) of risk factors and influence of interventions during the recovery period

Loomes

Louro

2021

Equine Veterinary Journal

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Background In equine anaesthesia, the recovery period is a time of considerable risk and has been the focus of prolific research. Risk factors, including age, type and duration of procedure or temperament may influence recovery quality. Unfortunately, the anaesthetist is unable to control for these factors, therefore various pharmacological interventions and recovery methods have been developed with the objective of improving recovery quality. However, no consensus among anaesthetists has been reached for many of these interventions and their implications for recovery‐related mortality and morbidity. Objectives To conduct a systematic review of the published evidence relating to risk factors and interventions in the recovery period which may influence recovery quality from equine general anaesthesia (GA). Study design A systematic evaluation of the equine veterinary literature using the GRADE framework. Methods A literature search was performed and studies were assessed for eligibility by both authors utilising PRISMA guidelines. Studies meeting inclusion criteria were evaluated by both authors, categorically summarised and the quality of evidence for each sub‐topic was assessed using the GRADE framework. Results Thirty‐nine studies were identified which directly assessed the impact of risk factors and recovery interventions on recovery quality after equine GA. There was evidence to support that peri‐anaesthetic risk factors such as anaesthesia duration, American Society of Anesthesiologists (ASA) physical status and surgical procedure influenced recovery quality. We also identified sufficient evidence that administration of α‐2 adrenoreceptor agonists immediately prior to recovery, improves recovery quality. Main limitations The validity of the results of some studies may have been compromised by missing data and small sample sizes. Conclusions Recovery quality is influenced by factors including: anaesthesia duration, ASA physical status and surgical procedure. Recovery quality can be improved by the administration of an α‐2 adrenoreceptor agonist immediately prior to recovery.

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“…In man, FeXe 70% is often associated with the administration of a potent μ agonist with sparing anesthetic effect, which leads us to think that the MAC might be different ( 2 ). Lidocaine volatile anesthetic-sparing effect in horses is well recognized ( 18 , 19 ). In order to imitate the sparing effect of fentanyl, we added lidocaine in our anesthetic protocol.…”

Section: Discussionmentioning

confidence: 99%

The Modification and Performance of a Large Animal Anesthesia Machine (Tafonius®) in Order to Deliver Xenon to a Horse

Santangelo

Robin

Simpson³

et al. 2017

Front. Vet. Sci.

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IntroductionXenon, due to its interesting anesthetic properties, could improve the quality of anesthesia protocols in horses despite its high price. This study aimed to modify and test an anesthesia machine capable of delivering xenon to a horse.Materials and methodsAn equine anesthesia machine (Tafonius, Vetronic Services Ltd., UK) was modified by including a T-connector in the valve block to introduce xenon, so that the xenon was pushed into the machine cylinder by the expired gases. A xenon analyzer was connected to the expiratory limb of the patient circuit. The operation of the machine was modeled and experimentally tested for denitrogenation, wash-in, and maintenance phases. The system was considered to consist of two compartments, one being the horse’s lungs, the other being the machine cylinder and circuit. A 15-year-old, 514-kg, healthy gelding horse was anesthetized for 70 min using acepromazine, romifidine, morphine, diazepam, and ketamine. Anesthesia was maintained with xenon and oxygen, co-administered with lidocaine. Ventilation was controlled. Cardiorespiratory variables, expired fraction of xenon (FeXe), blood gases were measured and xenon was detected in plasma. Recovery was unassisted and recorded.ResultsFeXe remained around 65%, using a xenon total volume of 250 L. Five additional boli of ketamine were required to maintain anesthesia. PaO2 was 45 ± 1 mmHg. The recovery was calm. Xenon was detected in blood during the entire administration time.ConclusionThis pilot study describes how to deliver xenon to a horse. Although many technical problems were encountered, their correction could guide future endeavors to study the use of xenon in horses.

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Comparison of the effects of an intravenous lidocaine infusion combined with 1% isoflurane versus 2% isoflurane alone on selected cardiovascular variables and recovery characteristics during equine general anaesthesia

Cited by 4 publications

References 10 publications

Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature

Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature

Recovery of horses from general anaesthesia: A systematic review (2000‐2020) of risk factors and influence of interventions during the recovery period

The Modification and Performance of a Large Animal Anesthesia Machine (Tafonius®) in Order to Deliver Xenon to a Horse

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