Comparison of the effect of hemihydrate calcium sulfate granules and Cerabone on dental socket preservation: An animal experiment

Abstract

Background. Early bone loss due to tooth extraction can be significantly reduced by socket preservation. The aim of this study was to compare the in vivo effects of hemihydrate calcium sulfate granules (an alloplastic material) and Cerabone (a bovine-derived xenograft) on socket preservation in dogs. Methods. Six male Mongrel dogs were randomly divided into 2 groups (n=3) for sacrificing and histological evaluation 4 and 8 weeks after a surgery. The second and third premolars on both sides of the lower jaw were extracted surgically. The sockets on one side were filled with Cerabone, and with calcium sulfate on the opposite side. In the slides, the ratio of the area of newly formed bone to the area of the entire cavity, and the ratio of the area of fibrous connective tissue to the area of the entire cavity were measured. The presence of inflammation was also examined. Wilcoxon signed-rank test, Sign test and McNemar test were used for statistical analyses (ɑ=0.05). Results. The means of new bone proportion were 11% and 8% for Cerabone and calcium sulfate, respectively (P=0.58). The means of connective tissue proportion were 29% and 33% for Cerabone and calcium sulfate, respectively (P=0.72). No inflammatory cells were observed in the Cerabone group, although 50% of the samples in the calcium sulfate group showed inflammation (P=0.50). Conclusion. The effects of calcium sulfate and Cerabone on socket preservation in dogs on bone formation, fibrous connective tissue and inflammation levels were not significantly different at 4- and 8-week postoperative intervals.

Histological Evaluation of Bone Regeneration Using Hydroxyapatite Based Bone Substitute Derived from Antler: An Animal Study

“…No residual graft particles were seen in this study groups and bone graft substitutes were completely integrated, which is in agreement with the results of the study by Sargolzaie et al 20 However, in the study by Sadeghi et al, 16 the amount of residual particles after 12 weeks was calculated as 20.45% in the nanocrystalline hydroxyapatite group and as 14.85% in the human freeze-dried bone graft group. The reason attributed to the presence of silicate compounds in the nanocrystalline hydroxyapatite was that they were encapsulated by fibrous connective tissue that takes time to be absorbed.…”

Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

“…Among all bone grafts, cerabone ® was selected as biomaterial in the control group. Cerabone ® has been well studied to date in both preclinical animal studies [ 50 , 51 , 52 , 53 , 54 , 55 , 56 ] and human clinical trials [ 57 , 58 , 59 ]. Socket preservation using cerabone ® has proven to be a reliable method to minimize the loss of bone volume at the extraction site [ 57 ].…”

Regeneration of Buccal Wall Defects after Tooth Extraction with Biphasic Calcium Phosphate in Injectable Form vs. Bovine Xenograft: A Randomized Controlled Clinical Trial

“…Previous studies do not indicate whether the percentage of soft tissue in the biopsies is clinically relevant, so it would be interesting to investigate in further studies whether this difference has clinical implications. Although this remains unknown for now, it is known from previous studies that the quality and quantity of regenerated bone and the absence of an inflammatory reaction of the tissue are important prerequisites for the long-term success of implant prosthetic therapy [ 57 , 58 ]. Our group of authors previously reported two histologic studies on the osteogenic potential of I-BCP compared with BX in different clinical indications.…”