Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Čandrlić, Marija; Tomas, Matej; Karl, Matej; Malešić, Lucija; Včev, Aleksandar; Kačarević, Željka Perić; Matijević, Marko

doi:10.3390/ijms23052539

Cited by 14 publications

(26 citation statements)

References 62 publications

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“…[17][18][19][20] BCPs have been produced by mixing HA and β-TCP powders, or by sintering CDHAs at high temperature to produce mixtures of the two different phases, 20 and injectable BCP particles have been recently evaluated as bone graft materials for oral surgery applications. 21 BCP microspheres have been proposed for similar bone tissue regeneration. 22 Their shape and flowability make microspheres candidates as injectable materials, 23,24 and by controlling their porosity, BCP microspheres could be tailored for drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

“…The ratio between the more soluble β‐TCP and the more stable HA can be varied to adjust the level of bioactivity, bioresorbability, osteoconductivity, and osteoinductivity 17–20 . BCPs have been produced by mixing HA and β‐TCP powders, or by sintering CDHAs at high temperature to produce mixtures of the two different phases, 20 and injectable BCP particles have been recently evaluated as bone graft materials for oral surgery applications 21 . BCP microspheres have been proposed for similar bone tissue regeneration 22 .…”

Section: Introductionmentioning

confidence: 99%

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Conversion of borate glass microspheres to hollow biphasic calcium phosphate ceramic microspheres for bone defects

2022

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Hollow biphasic calcium phosphate (BCP) microspheres with different fractions of nanocrystalline hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) were prepared, and their in vitro and in vivo reactivity were assessed. The microspheres were prepared by reacting soluble borate glass microspheres in phosphate solutions (0.1-or 0.25-M K 2 HPO 4 ) with different values of pH (7-12) to produce hollow calcium-deficient hydroxyapatite (CDHA) microspheres with Ca/P ratios that increased with solution pH. Heating the hollow CDHA microspheres to 800 • C produced hollow, nanoporous BCP microspheres with ratios of nanocrystalline HA and β-TCP that correspond to the Ca/P ratio of the CDHA precursors. Hollow BCP microspheres with a greater fraction of β-TCP released calcium ions most quickly in a K-acetate acidic buffer solution, consistent with their greater bioactivity in the in vivo tests. CDHA and BCP microspheres converted to nanocrystalline carbonated HA when immersed in 37 • C simulated body fluid. Hollow CDHA and BCP microspheres were implanted in rat calvarial defects, and after 8 weeks, the BCP microspheres with a β-TCP/HA ratio of 70/30 (by weight) promoted a greater fraction of new bone formation (33% ± 7%) compared to BCP microspheres with a β-TCP/HA ratio of 44/56 (20% ± 9%) and compared to the respective CDHA precursor microspheres (17% ± 4%, 17% ± 5%). Bone formation was not observed in the subcutaneous implants of any types of these hollow microspheres, after 8 and 12 weeks, and the more reactive BCP microspheres (β-TCP/HA = 70/30) were associated with significantly more blood vessel formation in the subcutaneous implants. These results indicate that the properties of hollow BCP microspheres can be tailored by their processing conditions and are useful as scaffold materials for tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conversion of borate glass microspheres to hollow biphasic calcium phosphate ceramic microspheres for bone defects

2022

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“…However, there was lesser remaining grafting material (BCP 25.3%; DBBM 45.9%) and greater non-mineralized tissue (BCP 38.1%; DBBM 18.2%) in BCP than that in DBBM after 6 months of healing [14]. Another comparative study evaluated BCP and DBBM when used for socket preservation [15]. Histomorphometric analysis performed 6 months after the procedure showed no significant difference in new bone formation and residual materials between the two groups.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, BCP has shown comparable favorable outcomes with deproteinized bovine bone mineral (DBBM), which is one of the most frequently used xenogeneic bone substitute materials [14,15]. A recent clinical study comparing histomorphometric outcomes of sinus floor elevation with BCP and DBBM demonstrated that the amount of new bone was similar between the two grafts (BCP 35.9%; DBBM 35.4%).…”

Section: Discussionmentioning

confidence: 99%

“…HA resorbs slowly and remains relatively stable, whereas β-TCP resorbs faster and releases calcium and phosphate ions to induce new bone formation [12]. Several preclinical in vitro studies have assessed the usage of different HA and β-TCP ratios in BCP, with some authors reporting no difference between different ratios in histological and volumetric outcomes, while other studies have reported a significant difference [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Case series of maxillary anterior bone augmentation with a novel biphasic calcium phosphate: a clinical and radiographic pilot study

Lee

Jung

et al. 2022

Oral Biol Res

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The purpose of this pilot case series was to evaluate the clinical and radiographic outcomes of employing newly developed alloplastic biphasic calcium phosphate (BCP) in guided bone regeneration (GBR) for maxillary anterior peri-implant defects. Six peri-implant dehiscence defects were grafted with BCP. For all included treatment sites, clinical (defect width [DW] and defect height [DH]), radiographic (horizontal hard tissue thickness [HT]), patient discomfort, and early wound healing outcomes were evaluated. At reentry surgery, all surgical sites indicated a change in DW, DH, HT0, HT1, HT2, and HT3 from 4.08±1.39 mm to 1.13±1.76 mm, 3.57±1.42 mm to 0.58±1.09 mm, 2.18±0.66 mm to 1.50±0.53 mm, 2.11±0.57 mm to 1.73±0.28 mm, 2.22±0.54 mm to 1.75±0.26 mm, and 2.63±0.87 mm to 1.83±0.46 mm, respectively. Significant differences were discovered between paired DW and DH (p<0.05), whereas radiographic parameters had no significant differences. The severity of pain and swelling was 4.8±1.9 and 6.5±1.9, respectively, and the duration of pain and swelling was 4.5±3.8 and 5.8±2.9 days, respectively, according to early postoperative discomfort assessment. No adverse reactions occurred at any treatment site. In terms of clinical and radiographic outcomes, the newly developed BCP is acceptable biocompatible and suitable for the GBR of maxillary anterior peri-implant dehiscence defects within the limitations of this study.

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From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

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Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach is employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra‐bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

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Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans

Cited by 14 publications

References 62 publications

Conversion of borate glass microspheres to hollow biphasic calcium phosphate ceramic microspheres for bone defects

Conversion of borate glass microspheres to hollow biphasic calcium phosphate ceramic microspheres for bone defects

Case series of maxillary anterior bone augmentation with a novel biphasic calcium phosphate: a clinical and radiographic pilot study

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

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