Comparison of the Clinical Efficacy of Abobotulinumtoxin A (ABO) and Onabotulinumtoxin A (ONA) in the Treatment of Crow’s Feet Wrinkles: A Split-Face Study

Elridy, Ahmed Shafik; Zaki, Rania Gamal Eldin; Elshinawy, Reham F.

doi:10.1080/08820538.2017.1418013

Cited by 5 publications

(8 citation statements)

References 12 publications

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“…17,30 In comparing study of Elridy (2018), the clinical efficacy of ABO and Onabotulinumtoxin A (ONA, Botox ® ) using a dosing ratio of 2.5U:1.0U in the treatment of crow's feet wrinkles, satisfaction was higher with ABO. 31 In Rystedt'…”

Section: Discussionmentioning

confidence: 99%

“…33 To improve skin texture, ABO was used in this study due to its most powerful potent and efficacy per unit. [31][32][33] Most European patients have thinner skin (dermis) than Asians, especially in women. Therefore, injection into dermis is very difficult for European physicians, and some of them did not distinguish the dermal injection from the subdermal injection.…”

Section: Discussionmentioning

confidence: 99%

“…Patients also experienced reduced oil secretions and skin pore size, likely due to dermatoxin effects (MicroBotox) by dermal hydration and dermatoxin activity on the sebaceous gland 17,30 . In comparing study of Elridy (2018), the clinical efficacy of ABO and Onabotulinumtoxin A (ONA, Botox ® ) using a dosing ratio of 2.5U:1.0U in the treatment of crow's feet wrinkles, satisfaction was higher with ABO 31 . In Rystedt’ comparison study (2008) of ABO and ONA, ABO at 200 U/ml was more potent than ONA at 100 U/ml with regard to both anhidrotic and muscular effects, and the equipotent concentration of ABO, compared with ONA 100 U/ml, was found to be in the range 100‐150 U/mL 32 .…”

Section: Discussionmentioning

confidence: 99%

“…A randomized, double‐blind, intra‐individual Nestor's study (2011) showed ABO with 2.5:1.0 ratio displayed significantly longer duration of action than ONA in the frontalis activity measurement standard 33 . To improve skin texture, ABO was used in this study due to its most powerful potent and efficacy per unit 31‐33 …”

Section: Discussionmentioning

confidence: 99%

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Topographic computer analysis for acne scar treatment on face accompanying biopsy study after dermal injection of hydrotoxin mixture

Kim

2020

J of Cosmetic Dermatology

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Background: Acne during youth can leave permanent facial scarring. The depressed acne scars can be treated by injection of stabilized hyaluronic acid (S-HA) into the dermis. Due to the large number of acne scars, manual injection methods are technically difficult and bear high risk of lump formation in the dermis. Therefore, the author designed a specific injection method to solve the two abovementioned problems. Aims: This research aims to assess the effect of the intradermal injection of S-HA and aboborulinumtoxinA mixture in the treatment of all types of acne scars. Materials/Methods: A total of 102 patients who suffered from acne scars were treated with a mixture of S-HA (Restylane Vital®) and abobotulinumtoxinA (Dysport ®). Using an automatic injector, micro-droplets of the mixture (0.001 cc of S-HA and 0.125 U abobotulinumtoxinA) were delivered into 1000 intradermal sites on whole face except eyelids. This instrument radically reduced injection amounts per site (0.001 cc), lessened manual operator efforts, and ensured consistent injection depth (from 0.8 to 1.2 mm depending on individual dermal thickness) into the facial dermis. The changes in each depression site of acne scars were evaluated by topographic computer analysis (point roughness), based on the 40 magnification microscopic photographs generated. Depth measurements of each small acne scar point were taken one by one at the exact same point before and after the treatments. Global Aesthetic Improvement Scale (GAIS) was measured for improvement of acne scars at 1-and 6-month posttreatment. Additionally, serial histologic examinations of the biopsy specimens evaluated neocollagenesis, neoelastinogenesis, and longevity state of the S-HA. Results: A total of 78 patients showed improvements of depressed acne scars in physical examinations, medical photographs, and dermascopic photographs. Using topographic computer analysis, the average point roughness decreased 27.48% (at 1 month) from 29.042 ± 6.85 (baseline) to 21.05 ± 6.30 µm (P < .0001), corresponding with scar improvements observed in physical examinations, and 3.02 ± 0.66 of GAIS at 1-month posttreatment. Using an injector allowed the hydrotoxin mixture This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Topographic computer analysis for acne scar treatment on face accompanying biopsy study after dermal injection of hydrotoxin mixture

Kim

2020

J of Cosmetic Dermatology

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“…Since then, there have been multiple studies that have evaluated and compared the safety and efficacy of other BTX-A formulations in the treatment of CFL. 16-20…”

Section: Introductionmentioning

confidence: 99%

Comparison of Prabotulinumtoxin A to Onabotulinumtoxin A in the Treatment of Lateral Canthal Rhytids: A Side-by-Side, Randomized, Double-Blind Comparison

Brundridge¹,

Czyz²,

Foster

et al. 2021

Am J Cosmet Surg

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Botulinum toxin type A (Onabotulinumtoxin A, Incobotulinumtoxin A, Abobotulinumtoxin A) has been successfully used in the treatment of lateral canthal rhytid (crow’s feet) reduction. Prabotulinumtoxin A is a newer medication that has been shown to have efficacy for the treatment of upper limb spasticity and improvement in moderate to severe glabellar lines. This study evaluated the onset of action, maximal effect, duration of action, and side effect profile for Prabotulinumtoxin A compared with Onabotulinumtoxin A in the treatment of crow’s feet. A total of 18 subjects aged 25 to 60 without a previous history of neuromuscular disorders, eyelid surgery, or botulinum toxin type A injections were included. Patients received 3 injections of botulinum toxin in the crow’s feet area on each side. Each side received 4U/.1cc of Prabotulinumtoxin A or Onabotulinumtoxin A at each site for a total of 12U/.3cc. The surgeon was masked to the serotype injected. The subjects had their lateral canthal areas photographed in relaxed and smiling positions preoperatively, daily from postinjection days 1 to 4, and weekly thereafter for a total of 12 weeks. Two masked oculoplastic surgeons were given the preoperative photos and postinjection photos and graded them on a scale of 0 to 3 (0 = no wrinkles, 1 = minimal wrinkles, 2 = moderate wrinkles, 3 = significant wrinkles). All subjects tolerated the injections well with no significant side effects or complications. The average onset of action was 3.47 days (1-14) for Onabotulinumtoxin A and 3.81 (1-14) for Prabotulinumtoxin A. The average time to peak effect was 11.11 days (1-56) for Onabotulinumtoxin A and 9.58 days (2-42) for Prabotulinumtoxin A. The average duration of action with improvement compared with baseline crow’s feet was 11.22 weeks (7-12) for Onabotulinumtoxin A and 11.11 weeks (6-12) for Prabotulinumtoxin A. Treatment of crow’s feet lines with Prabotulinumtoxin A achieves a comparable efficacy and safety profile compared with Onabotulinumtoxin A at a 1:1 dose. Therefore, Prabotulinumtoxin A can be used as another option in the treatment of crow’s feet.

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AbobotulinumtoxinA for Facial Rejuvenation: What Affects the Duration of Efficacy?

Warren

Welch

Coquis-Knezek

2020

Plastic Surgical Nursing

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Comparison of the Clinical Efficacy of Abobotulinumtoxin A (ABO) and Onabotulinumtoxin A (ONA) in the Treatment of Crow’s Feet Wrinkles: A Split-Face Study

Abstract: ABO is a safe, effective alternative to ONA in treating crow's feet wrinkles.

Cited by 5 publications

References 12 publications

Topographic computer analysis for acne scar treatment on face accompanying biopsy study after dermal injection of hydrotoxin mixture

Topographic computer analysis for acne scar treatment on face accompanying biopsy study after dermal injection of hydrotoxin mixture

Comparison of Prabotulinumtoxin A to Onabotulinumtoxin A in the Treatment of Lateral Canthal Rhytids: A Side-by-Side, Randomized, Double-Blind Comparison

AbobotulinumtoxinA for Facial Rejuvenation: What Affects the Duration of Efficacy?

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