1981
DOI: 10.1111/j.1471-4159.1981.tb04663.x
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Comparison of the Binding of [3H]Spiperone and [3H]Domperidone in Homogenates of Mammalian Retina and Caudate Nucleus

Abstract: The specific binding of [3H]spiperone and [3H]domperidone, as defined by 1 microM-(+)butaclamol, was compared in homogenates of bovine retina and caudate nucleus. Scatchard analyses of saturation data for [3H]spiperone binding yielded dissociation constants (Kd) of 0.35 nM in the retina and 0.64 nM in the caudate nucleus. Comparison of the maximum number of binding sites (Bmax) present in each tissue indicated that the density of sites in bovine caudate nucleus (270 fmol/mg protein) was approximately three tim… Show more

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Cited by 50 publications
(13 citation statements)
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References 41 publications
(46 reference statements)
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“…This conclusion is supported by the detection of dopamine in retinal neurons by the Falk-Hillarp method (Ehinger, 1966), the demonstration of dopamine synthesis and the detection of light-evoked release of dopamine in the retina (Da Prada, 1977;Kramer, 1971), and the presence of dopamine-specific receptors (Watling & Iversen, 1981). This conclusion is supported by the detection of dopamine in retinal neurons by the Falk-Hillarp method (Ehinger, 1966), the demonstration of dopamine synthesis and the detection of light-evoked release of dopamine in the retina (Da Prada, 1977;Kramer, 1971), and the presence of dopamine-specific receptors (Watling & Iversen, 1981).…”
Section: Catecholamines In the Vertebrate Retinamentioning
confidence: 93%
“…This conclusion is supported by the detection of dopamine in retinal neurons by the Falk-Hillarp method (Ehinger, 1966), the demonstration of dopamine synthesis and the detection of light-evoked release of dopamine in the retina (Da Prada, 1977;Kramer, 1971), and the presence of dopamine-specific receptors (Watling & Iversen, 1981). This conclusion is supported by the detection of dopamine in retinal neurons by the Falk-Hillarp method (Ehinger, 1966), the demonstration of dopamine synthesis and the detection of light-evoked release of dopamine in the retina (Da Prada, 1977;Kramer, 1971), and the presence of dopamine-specific receptors (Watling & Iversen, 1981).…”
Section: Catecholamines In the Vertebrate Retinamentioning
confidence: 93%
“…was chosen to investigate putative hypothalamic and pitu¬ itary gland dopamine receptors in mammalian neural tissue (Baudry, Martres & Schwartz, 1979;Sokoloff, Martres & Schwartz, 1980;Watling & Iversen, 1981). …”
Section: Measurement Of Dopamine-binding Sitesmentioning
confidence: 99%
“…A highly specific dopamine-sensitive adenylate cyclase is found in the teleost retina that possesses pharmacological properties very similar to those of the dopamine-sensitive adenylate cyclase in the mammalian brain (12,13). Although most dopamine receptors in the retina appear to be of the DI type (14,15), recent evidence suggests the presence of a small population ofdopamine receptors not associated with adenylate cyclase (16).…”
mentioning
confidence: 95%
“…The remaining 16 ml of Ringer's solution, containing clumps of cells, was discarded. The gradient vessels were funnel-shaped, with a diameter of 5 cm and a depth of 7 cm.…”
mentioning
confidence: 99%