1989
DOI: 10.1677/joe.0.1210067
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The functional activity of hypothalamic dopamine in broody bantam hens

Abstract: An assessment was made of the possible role of hypothalamic dopamine in the regulation of changes in plasma prolactin and LH in laying and broody bantam hens. Specific dopamine-binding sites were identified, using [3H]domperidone, in the anterior pituitary gland and in the anterior and posterior hypothalamus. The mean concentrations of dopamine-binding sites in both parts of the hypothalamus were 59-66 fmol/mg protein and did not differ between laying and incubating hens. The concentration of dopamine binding … Show more

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Cited by 30 publications
(11 citation statements)
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“…D 2 DA receptors on pituitary lactotropes inhibit PRL release in both mammals [3]and birds [24]and DA-binding sites in the anterior pituitary of bantam hens decrease during incubation [46]. The present findings clearly indicate that the differential expression of inhibitory D 2 DA receptor mRNA in the turkey pituitary is correlated with the degree of prolactinemia, since D 2 DA receptor mRNA increases in the pituitary of hypoprolactinemic photorefractory hens.…”
Section: Discussionsupporting
confidence: 57%
See 1 more Smart Citation
“…D 2 DA receptors on pituitary lactotropes inhibit PRL release in both mammals [3]and birds [24]and DA-binding sites in the anterior pituitary of bantam hens decrease during incubation [46]. The present findings clearly indicate that the differential expression of inhibitory D 2 DA receptor mRNA in the turkey pituitary is correlated with the degree of prolactinemia, since D 2 DA receptor mRNA increases in the pituitary of hypoprolactinemic photorefractory hens.…”
Section: Discussionsupporting
confidence: 57%
“…D 1 and D 2 DA receptors are stimulatory and inhibitory, respectively, to PRL release and expression in birds [18, 24]. The existence of specific DA-binding sites has been identified in the hypothalamus of the bantam hen [46]and D 1 -like DA receptors exist in the brain of the pigeon [47, 48], the European starling [49], the quail [50], and the chick [51]. D 2 -like DA receptors have been found in the pigeon [48]and quail brain [52]and D 1 and D 2 DA receptor subtypes have been cloned from the hypothalamus of the chick [21]and turkey [23].…”
Section: Discussionmentioning
confidence: 99%
“…In the chicken, DA inhibits the release of PRL stimulated by TRH, hypothalamic extract, or by previous exposure of the pituitary gland to estrogen (Hall & Chadwick 1984). Specific DA-binding sites identified in the anterior pituitary are found to be more abundant in laying than in incubating hens (Macnamee & Sharp 1989). Moreover, in cultured turkey pituitary cells, D 2 DA receptor agonists (D 2 AGs) inhibit VIP-stimulated PRL release and PRL mRNA steady-state levels (Xu et al 1996).…”
Section: Introductionmentioning
confidence: 99%
“…Pharmacological evidence suggests an inhibitory role for DA on LHRH release in mammals [9] as well as birds [5,[10][11][12][13]. Furthermore, the turnover of DA is depressed at the time of the preovulatory LH surge in both mam mals and birds [12,14] and an increased turnover of DA has been causally related to cessation of lay in birds [5,12,13,15], Several environmental conditions associated with low LH have been shown to precipiate ovulatory fail ure, among them undernutrition. In hens, temporary feed withdrawal (FW) causes a transient ovulatory fail ure and is an accepted method for extending the prof itable life of a laying flock, since egg production in creases after the anovulatory period is over [16], For example, FW for 4 days in laying hens at the end of their commercial egg-producing life induces a tempo rary ovulatory failure associated with low basal circulat ing levels of LH.…”
mentioning
confidence: 99%