Comparison of taurine, GABA, Glu, and Asp as scavengers of malondialdehyde in vitro and in vivo

Deng, Yan; Wang, Wei; Yu, Pingfeng; Xi, Zhijiang; Xu, Lijian; Li, Xiaolong; He, Nongyue

doi:10.1186/1556-276x-8-190

Cited by 53 publications

(27 citation statements)

References 44 publications

(53 reference statements)

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“…Nevertheless, according to the results of the current work, the significant improvement in all the studied parameters could be attributed to the role of GABA in attenuating oxidative stress through increasing endog enous superoxide dismutase (SOD) and CAT activities, decreasing lipid peroxidation 49 due to its free radicals scavenging activities, 50 its effectiveness in inhibiting the formation of reactive carbonyl intermediates and to react with MDA, increased in diabetic subjects as a side effect of increased protein glycation, to form different conjugated complexes 51 thus protect the tissue against active carbonyl damage. Treatment of the diabetic rats with GABA reduced the severity of changes in the intestinal epithelial cells where the villi appeared slightly hypertrophic with moderate lymphocytic infiltration in the connective tissue core.…”

supporting

confidence: 57%

Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats

Eltahawy¹,

El-Hady²,

Badawi³

et al. 2017

IJPER

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Introduction:The small intestine exhibits morphological and functional changes in streptozotocin (STZ)-induced diabetes. This study was carried out to clarify the role of gamma-aminobutyric acid (GABA) in ameliorating the histopathological changes and the oxidative stress in small intestine of the diabetic rats. Material and Methods: For this purpose, 40 adult male Swiss albino rats (Sprague dawley strain) were divided into 4 groups (10 animals in each group); the control group, GABA treated group, the diabetic group and the fourth group was subjected to induction of diabetes and GABA treatment. All animals were sacrificed and specimens from jejunum were removed and processed for the histopathological examinations, cytomorphometric analysis and oxidative stress assessment. Results: In diabetic rats, Jejunal sections from the diabetic rats exhibited pleomorphism of villi, inflammatory cellular infiltration and edema in the villous core with lymphoid hyperplasia, an increase in goblet cells number was also observed with disappearance of Paneth cells or they were degranulated, increased crypt numbers and mucosal height and increased thickness of muscularis layer. Moreover, there was an increase in the oxidant biomarkers with decline in the antioxidant enzymes in Jejunal sections of the diabetic rats. Conclusion: Treatment of rats with GABA ameliorated the observed histopathological alterations, morphometric changes and improved the oxidant/ antioxidant statusof the jejunum in diabetic rats. Based on these results, it was concluded that GABA administration to rats ameliorated diabetes-induced jejunal histopathological and biochemical alterations.

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supporting

confidence: 57%

Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats

Eltahawy¹,

El-Hady²,

Badawi³

et al. 2017

IJPER

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“…Glutamate, the raw material for glutathione synthesis in the antioxidation system, recover and maintain the reduced glutathione level, by this way improving the activity of GSH-Px in the antioxidation system (Chen, Tang, Sun, & Xie, 2013). Moreover, the modulator role of GABA following radiation exposure may also be attributed to its antioxidant and free radical-scavenging activities (Deng et al, 2013;Eltahawy, Abd El-Hady, Badawi, & Hammad, 2017). Thus, GABA can attenuate various morphological, histopathological, and biochemical changes resulting from intestinal injury following radiation exposure demonstrating that GABA provides a significant ameliorative effect against intestinal injury following irradiation process.…”

Section: Discussionmentioning

confidence: 99%

“…It has paracrine and autocrine properties in various peripheral tissues (Watanabe et al, 2002). It has a role in the inhibition of many inflammatory cellular reactions (Tian et al, 2011) and has antidiabetic (Soltani et al, 2011), antioxidant, and free radical-scavenging properties (Deng et al, 2013). GABA is found all over the GI tract, in endocrine-like cells, and in enteric nerves, and it is considered as a neurotransmitter with an endocrine GI tract function (Hyland & Cryan, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

El-Hady¹,

Gewefel²,

Badawi³

et al. 2017

JoBAZ

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Background: The current study aimed to evaluate the role of gamma-amino butyric acid (GABA) in modulating histopathological and biochemical disturbances in the rat's small intestine following gamma radiation exposure. Results:The results showed that whole body gamma irradiation (6 Gy) of rats induced mucosal damage, hemorrhage, increased cellularity of the lamina propria layer with areas of complete ulcerations. Histopathological changes were associated with a significant increase in malondialdehyde (MDA) and advanced oxidation protein products (AOPPs). In parallel, a significant decrease in catalase (CAT) and glutathione peroxidase (GSH-Px) activities was demonstrated. Administration of GABA (200 mg/kg body weight GABA daily via gastric gavage for three consecutive weeks) after irradiation of rats has significantly improved the oxidant/antioxidant status which was associated with regeneration of the small intestinal cell structure. Conclusion: Gastric administration of GABA was found to offer an advantageous treatment against gamma irradiation-induced small intestine oxidative stress in rats, probably by utilizing ameliorative effects via its antioxidant and free radical-scavenging activities. Its mechanisms need to be further investigated.

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“…Enzyme activities were expressed relative to protein concentrations, which were estimated by the method of Deng et al (2013) using bovine serum albumin as standard. We employed the dying method of Coomassie brilliant blue G-250 to determine the protein concentration of algal samples, measuring the absorbency at the wavelength of 595 nm.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant responses and photosynthetic behaviors of Kappaphycus alvarezii and Kappaphycus striatum (Rhodophyta, Solieriaceae) during low temperature stress

Liu

Zhang

2016

Bot Stud

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Background Kappaphycus are farmed in tropical countries as raw material for carrageenan, which is widely used in food industry. The sea area available for farming is one limiting factor in the production of seaweeds. Though cultivation is spreading into subtropical regions, the lower seawater temperature is an important problem encountered in subtropical regions for the farming of Kappaphycus. This research of physiological response to low temperature stress will be helpful for screening Kappaphycus strains for growth in a lower temperature environment.ResultsResponses of antioxidant systems and photosystem II (PSII) behaviors in Kappaphycus alvarezii and Kappaphycus striatum were evaluated during low temperature treatments (23, 20, 17 °C). Compared with the controls at 26 °C, the H2O2 concentrations increased in both species when the thalli were exposed to low temperatures (23, 20, 17 °C), but these increases were much greater in K. striatum than in K. alvarezii thalli, suggesting that K. striatum suffered more oxidative stress. The activities of some important antioxidant enzymes (e.g. superoxide dismutase and ascorbate peroxidase) and the hydroxyl free radical scavenging capacity were substantially higher at 23, 20 and 17 °C than at the control 26 °C in K. alvarezii, indicating that the antioxidant system of K. alvarezii enhanced its resistance to low temperature. However, no significant increases of antioxidant enzymes activities were observed at 20 and 17 °C in K. striatum. In addition, both the maximal efficiency of PSII photochemistry (FV/Fm) and the performance index (PIABS) decreased significantly in K. striatum at 23 °C, indicating that the photosynthetic apparatus was damaged at 23 °C. In contrast, no significant decreases of either FV/Fm or PIABS were observed in K. alvarezii at 23 °C.ConclusionsIt is concluded that K. alvarezii has greater tolerance to low temperature than K. striatum.

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Comparison of taurine, GABA, Glu, and Asp as scavengers of malondialdehyde in vitro and in vivo

Cited by 53 publications

References 44 publications

Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats

Gamma Amino Butyric Acid Ameliorates Jejunal Oxidative Damage in Diabetic Rats

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

Antioxidant responses and photosynthetic behaviors of Kappaphycus alvarezii and Kappaphycus striatum (Rhodophyta, Solieriaceae) during low temperature stress

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