Comparison of Short- and Long-term Function and Radiographic Osteoarthrosis in Dogs After Postoperative Physical Rehabilitation and Tibial Plateau Leveling Osteotomy or Lateral Fabellar Suture Stabilization

Au, Kevin K.; Gordon‐Evans, Wanda J.; Dunning, Dianne; O'Dell-Anderson, Kristen; Knap, Kim E.; Griffon, Dominique J.; Johnson, Ann L.

doi:10.1111/j.1532-950x.2009.00628.x

Cited by 110 publications

(160 citation statements)

References 27 publications

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“…Treatment involves surgical joint stabilization and the medical management of pain and inflammation. To restore joint stability, tibial plateau leveling osteotomy (TPLO) is one of the most common surgical procedures performed worldwide (4–6), delivering quick and good clinical outcomes for a majority of the treated dogs (7–11). The biomechanical purpose of TPLO is to decrease the tibial slope angle through radial proximal tibial osteotomy, so the joint stability during gait no longer relies on the integrity of the cranial cruciate ligament.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Taroni

Cabon

Febre³

et al. 2017

Front. Vet. Sci.

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ObjectiveCompare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs).Study designProspective, double-blinded, randomized, controlled, monocentric clinical study.AnimalsSixteen client-owned dogs.Materials and methodsDogs with unilateral CrCLR confirmed by arthroscopy were included. Allogeneic neonatal canine MSCs were obtained from fetal adnexa retrieved after C-section performed on healthy pregnant bitches. The dogs were randomly allocated to either the “MSCs group,” receiving an IA injection of MSCs after TPLO, followed by placebo for 1 month, or the “NSAIDs group,” receiving IA equivalent volume of MSCs vehicle after TPLO, followed by oral NSAID for 1 month. One of the three blinded evaluators assessed the dogs in each group before and after surgery (1, 3, and 6 months). Clinical score and gait and bone healing process were assessed. The data were statistically compared between the two groups for pre- and postoperative evaluations.ResultsFourteen dogs (nine in the MSCs group, five in the NSAIDs group) completed the present study. No significant difference was observed between the groups preoperatively. No local or systemic adverse effect was observed after MSCs injection at any time point considered. At 1 month after surgery, bone healing scores were significantly higher in the MSCs group. At 1, 3, and 6 months after surgery, no significant difference was observed between the two groups for clinical scores and gait evaluation.ConclusionA single IA injection of allogeneic neonatal MSCs could be a safe and valuable postoperative alternative to NSAIDs for dogs requiring TPLO surgery, particularly for dogs intolerant to this class of drugs.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Taroni

Cabon

Febre³

et al. 2017

Front. Vet. Sci.

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“…Many recent studies have shown surgical stabilization to be effective in managing cranial cruciate ligament insufficiency (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). While there are numerous options for surgical management, surgery is not always an option.…”

Section: Introductionmentioning

confidence: 99%

The Use of Canine Stifle Orthotics for Cranial Cruciate Ligament Insufficiency

Carr¹,

Canapp²,

Meilleur³

et al. 2016

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Objective: To assess weight bearing of dogs treated for unilateral cranial cruciate ligament insufficiency with a custom stifle orthotic.Background: Cranial cruciate ligament (CCL) insufficiency is the most common cause of hind limb lameness in dogs. While there are numerous options for surgical management, surgery is not always an option. Recently, the use of canine stifle orthotics has also emerged as a means to non-surgically manage patients with cranial cruciate ligament insufficiency.

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“…102 in the treatment of chronic disease, such as DJD or conformational abnormalities, rehabilitation should be considered an important component of an overall long-term treatment strategy. 103 The foundation of rehabilitation is therapeutic exercise that aims to restore musculoskeletal strength and function, endurance and proprioception, and reduce pain.…”

Section: Physical Rehabilitationmentioning

confidence: 99%