Comparison of serum cardiac troponin T and creatine kinase MB isoenzyme mass concentrations in asphyxiated term infants during the first 48 h of life

Ny, Boo; Hafidz, Hasri; Nawawi, Hapizah Md; Cheah, Fook-Choe; Fadzil, Yong Junina; Abdul-Aziz, Bilkis B.; Ismail, Zulkifli

doi:10.1111/j.1440-1754.2005.00626.x

Cited by 37 publications

(35 citation statements)

References 24 publications

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“…Cardiac troponin T concentrations remained high also on the 3rd and 7th day of life [13,15,18]. In the present study no correlation between cTnT concentrations and Agar scoring in the 1st or 5th minute of life was found.…”

Section: Discussioncontrasting

confidence: 48%

“…Güneś et al [15], Boo et al [13], and Costa et al [18] revealed that newborns born with severe perinatal anoxia had significantly higher cTnT concentrations during the first hours of life, compared with newborns born in good or moderate condition. Cardiac troponin T concentrations remained high also on the 3rd and 7th day of life [13,15,18].…”

Section: Discussionmentioning

confidence: 99%

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The Evaluation of Cardiac Troponin T in Newborns

Tarkowska

Furmaga-Jabłońska

2017

Biomed Hub

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Introduction: In this paper, we evaluated the physiologic ranges of cardiac troponin T (cTnT) serum concentrations in healthy newborns. This is significant because these ranges have not been determined yet, especially for newborns older than 7 days. Cardiac troponins are widely used as diagnostic markers in adults; however, they cannot be routinely used in infants due to lack of data concerning normal values in this age group. Aim: To determine the physiologic ranges of cTnT concentrations in newborns and to evaluate the influence of factors such as age, sex, and blood saturation. Methods: The study involved 59 newborns up to 46 weeks of postmenstrual age (full-term and preterm). The exclusion criteria were severe perinatal asphyxia and presence of severe diseases. Troponin T concentrations were evaluated by the Roche CARDIAC T Quantitative Test. The obtained results were statistically analyzed by the use of the Statistica 9.0 computer program. Results: The study revealed that cTnT levels in newborns correlate with postmenstrual age, but not with chronologic or fetal age. Sex, delivery mode, and blood oxygenation did not influence cTnT concentrations in the studied patients. Conclusions: (1) Cardiac troponin T concentration depends on postmenstrual age in newborns. (2) Cardiac troponin T concentration in newborns does not depend on sex, mode of delivery, or blood saturation.

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Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

The Evaluation of Cardiac Troponin T in Newborns

Tarkowska

Furmaga-Jabłońska

2017

Biomed Hub

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“…Boo et al [32] compared 50 asphyxiated and 50 controls matched for birth weight, gestation and gender. The asphyxiated group had higher cTnT levels compared to controls at birth (0.1 vs. 0.02 g/l).…”

Section: Troponin T and Asphyxiamentioning

confidence: 99%

Serum Troponin in Neonatal Intensive Care

El-Khuffash

Molloy

2007

Neonatology

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Cardiac troponins have a major role in screening and diagnosis of myocardial ischaemia in adults and children. Their introduction has redefined the diagnosis of myocardial infarction in adults and provided valuable prognostic information. In the paediatric population, troponins show a good correlation with the extent of myocardial damage following cardiac surgery and cardiotoxic medication, and can be used as predictors of subsequent cardiac recovery and mortality. This review discusses the current established reference values in term and preterm infants and demonstrates their potential use in neonatology. They may serve as a useful adjunct in the assessment of the magnitude of myocardial injury in respiratory distress syndrome and asphyxia. They may also benefit centres without on-site echocardiography with some evidence showing good correlation with echo-derived markers of myocardial function. The use of troponins in the neonatal unit remains a research tool. More work is needed to explore their prognostic role and monitoring response to treatment following cardioprotective strategies. In preterm infants the effect of inotropes on myocardial function needs further study and troponin may form an integral part of this research.

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“…However, unlike in the adult population, circulatory failure is not a common cause of adverse outcomes in newborn infants (51,52). Boo et al did find that cTnT levels were significantly higher in infants who did not go on to survive, thereby suggesting that cardiac troponins can be used to predict short-term outcomes as well as longterm prognosis (53). Kanik et al reported that survivors of neonatal encephalopathy had significantly lower cTnI levels at days 1 and 3 (54).…”

Section: Reviewmentioning

confidence: 97%