The Evaluation of Cardiac Troponin T in Newborns

Tarkowska, A; Furmaga-Jabłońska, Wanda

doi:10.1159/000481086

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…We also could not find other studies to compare our results and it seems further studies are needed to clarify this possible relationship. Finally, we could not find any correlations between Troponin T levels with maternal age, parity, neonatal gestational age, sex, or anthropometric measures that these findings were confirmed by previous studies [17][18][19].…”

Section: Discussionsupporting

confidence: 79%

Finding a biomarker to predict patent ductus arteriosus in preterm babies

Veysizadeh¹,

Khodadadi²,

Zarkesh³

et al. 2022

World J. Adv. Res. Rev.

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Background: Few studies have evaluated the relationship between the presence of PDA and cardiac troponin T (cTnT) levels; however, the results are conflicting. The present study aimed to compare blood cTnT levels among preterm neonates with and without PDA. Methods: A case-control study was conducted at Iranian Hospital in 2021. For all included neonates, echocardiography examination was performed on admission time. According to the clinical presentation and echocardiography findings, preterm neonates were divided into the case (with PDA) and control (without PDA) groups. A blood test was also performed for all participants to detect levels of plasma cTnT. Finally, the levels of plasma cTnI (ng/ml) were compared between the case and control groups. Results: Totally 36 neonates (12 with PDA and 24without PDA) aged 1.972±0.696 days entered the study. The mean neonatal Troponin T level was 116.352±83.470 ng/ml. The results have shown no significant difference between the groups regarding the means of Troponin level (124.506±113.138 and 112.275±66.546; P=0.476). The results have indicated that there were significant and inverse correlations between the cTnT level with the 1st (Correlation Coefficient= -0.450; P=0.006) and 5th (Correlation Coefficient=-0.532; P=0.001) minutes Apgar Scores. This relationship was also observed between the mean of TnT level and maternal gravidity (Correlation Coefficient= -0.356; P=0.033). Conclusion: The results of the present study delineate no correlation between the presence of PDA and increased blood cTnT levels in preterm neonates. While low Apgar scores at 1 and 5 minutes as well as maternal gravidity could significantly change the levels of cardiac troponin T levels.

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Section: Discussionsupporting

confidence: 79%

Finding a biomarker to predict patent ductus arteriosus in preterm babies

Veysizadeh¹,

Khodadadi²,

Zarkesh³

et al. 2022

World J. Adv. Res. Rev.

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“…For example, high-sensitivity cardiac troponin T (hs-cTnT) is associated with the incidence of diabetes [17] and acute ischemic stroke [18]. Several reports studied relations between blood cTnT levels and neonates' health status [19][20][21][22][23][24]. As shown in previous studies [25,26], the size of troponin molecules prevents crossing the placenta, and therefore mother blood levels of cTnT cannot influence neonatal serum troponin levels.…”

Section: Discussionmentioning

confidence: 97%

Cardiac Troponin T in Neonates from Normal and Gestational Diabetes Mellitus Pregnancy

Kłaczewska¹,

Tomasiuk

2022

BioMed Research International

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This study is aimed at testing the hypothesis that serum analysis of high-sensitivity troponin T in neonates may serve as a diagnostic tool to predict the risk of gestational diabetes mellitus (GDM). 86 newborns were studied and stratified into two groups: healthy group; newborns with body weight ≥ 10 th percentile, born in good condition (APG 8-10pts) of pregnancy not complicated by diabetes, and the GDM group; neonates born to mothers with type 1 or type 2 diabetes. Results. The study revealed minimal troponin levels in GDM, and healthy groups equal to 0.02 ng/mL and 0.028 ng/mL, respectively. The GDM group is defined by an interquartile range of hs-TnT higher than the healthy group. This study confirms previously reported upper levels of troponin in healthy children. There are possible health problems that can appear during infancy and influence the further development of a child affected by GDM.

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“…The heart is essentially a muscle, and damage to the heart causes it to release troponin into the bloodstream. Troponin I levels in the blood are very low (<30 pg/mL in newborns) [19], but injuries to the heart can cause the levels to increase significantly. Troponin T is a commonly used cardiac biomarker that may be useful for determining whether patients have perinatal asphyxia.…”

Section: Biomarkers Associated With Cardiopulmonary Comorbiditymentioning

confidence: 99%

Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes

Lee

Wong

et al. 2021

JCM

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Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic–Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional outcomes, and neurodevelopmental outcomes at 1 year. Seventy-three patients were divided into two groups: mild HIE and moderate to severe HIE. Troponin I levels within 6 h of birth were obtained in 61 patients, and were significantly higher in patients with moderate to severe HIE than in patients with mild HIE (Mann–Whitney U test, U = 146, p = 0.001). A troponin I cut-off level of ≥60 pg/mL predicted moderate to severe HIE with a specificity of 81.1% and a negative prediction rate of 76.9%. A troponin I cut-off level of ≥180 pg/mL was significantly (χ2 (1, n = 61) = 33.1, p = 0.001, odds ratio 96.8) related with hypotension during first admission and significantly (χ2 (1, n = 61) = 5.3, p = 0.021, odds ratio 4.53) related with abnormal neurodevelopmental outcomes at 1 year. Early troponin I level may be a useful biomarker for predicting moderate to severe HIE, and initialization of hypothermia therapy.

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The Evaluation of Cardiac Troponin T in Newborns

Cited by 4 publications

References 17 publications

Finding a biomarker to predict patent ductus arteriosus in preterm babies

Finding a biomarker to predict patent ductus arteriosus in preterm babies

Cardiac Troponin T in Neonates from Normal and Gestational Diabetes Mellitus Pregnancy

Troponin I Levels in Neonatal Hypoxic–Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes

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