Serum Troponin in Neonatal Intensive Care

El-Khuffash, Afif; Molloy, Eleanor J.

doi:10.1159/000112540

Cited by 39 publications

(59 citation statements)

References 85 publications

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“…Cardiac troponins (cTn) have a high sensitivity and specificity for myocardial injury. Troponin consists of three subunits: troponin I (cTn-I), troponin T (cTn-T), and troponin C. Troponin T and I are ideal diagnostic markers for myocardial injury since the heart and extracardiac muscle express distinct isoforms which are encoded by different genes (El-Khuffash and Molloy, 2008;Undhad et al, 2012). Owing to the positive correlation between the concentration of troponin and the size of myocardial injury developing after cardiac surgery or cardiotoxic drug treatment, troponin is useful as a prognostic indicator of mortality and morbidity in the paediatric age group.…”

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Cardiac biomarkers in premature calves with respiratory distress syndrome

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et al. 2016

Acta Veterinaria Hungarica

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The aim of this study was to determine the clinical relevance of cardiac biomarkers [troponin I and T, creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH)] in premature calves with respiratory distress syndrome. Seventy premature calves were admitted to the clinic within 24 h after birth. Respiratory distress syndrome was diagnosed in premature calves by clinical examination and venous blood gas analysis. Ten healthy calves, aged 5 days, were used as control. Cardiac troponin I and T were analysed using ELISA and ELFA, respectively. Serum CK-MB and LDH were also analysed in an automatic analyser. The calves had low venous pH, pO 2 , O 2 saturation and high pCO 2 values consistent with dyspnoea, hypoxaemia, and inadequate oxygen delivery. Mean serum troponin I, troponin T, CK-MB and LDH levels were increased in the premature calves compared to the control group. In conclusion, the results in this study demonstrated that serum CK-MB, troponin I and troponin T concentrations could be used for evaluating myocardial injury in premature calves with respiratory distress syndrome.

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Cardiac biomarkers in premature calves with respiratory distress syndrome

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et al. 2016

Acta Veterinaria Hungarica

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“…Son yıllarda yenidoğan döneminde kardiyak troponinlerin, asfiktik bebeklerdeki miyokard hasarını yansıtabileceği tartışılırken, birçok merkez bu amaçla kardiyak troponin düzeylerini incelemektedir (7,8,22,24). Türker ve ark.…”

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The Evaluation Of The Association Of Laboratory Tests Associated With Mortality In Term Neonates With Hypoxic-ischemic Encephalopathy

Can¹,

Bülbül²,

Nuhoğlu³

2010

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ÖZETAmaç: Hipoksik iskemik ensefalopati (HİE) tanılı zamanında doğan yenidoğan bebeklerin erken dönem laboratuvar testlerinin mortalite ile ilişkisinin değerlendirilmesi. Gereç ve Yöntemler: Ocak 2004-Aralık 2008 tarihleri arasında HİE tanısı alan yenidoğan bebekler; yaşayan ve ölen olarak iki gruba ayırılarak prospektif olarak incelendi.Bulgular: Çalışmaya 32 yenidoğan alındı. Sarnat&Sarnat'a göre bebeklerin 9'u (%28.1) evre 1, 14'ü (%43.8) evre 2 ve 9'u (%28.1) evre 3 idi. Bebeklerin 8'i (%25) kaybedildi. Risk faktörlerinin korelasyon değerlendirme-sinde; antenatal takipsizlik (r²=0.35) ve konvülsiyon geçirmenin (r²=0.50) Sarnat evresi ile, Sarnat evresinin de mortalite ile pozitif ilişkili olduğu saptandı (r²=0.57). Laboratuvar testlerinde CK-MB ölüm oranı ile kuvvetli ilişkili (r²=0.74), troponin-I orta düzeyde ilişkili (r²=0.44), pH ise zayıf ilişkili bulundu (r²=0.27). Mortalite için CK-MB ve Troponin-I seviyelerinin prediktivitesinin yüksek, pH'nın ise orta dereceli olduğu saptandı. CK-MB'nin mortalite için duyarlılığı %100, özgüllüğü %91.6; Troponin-I'nın mortalite için duyarlılığı %100 ve özgüllüğü %70.8; pH'nın mortalite için duyarlılığı %75 ve özgüllüğü %87.5 bulundu.Sonuç: HİE tanılı zamanında doğmuş yenidoğan bebeklerde, erken dö-nem ölüm oranlarının, CK-MB değeri ile yüksek, Troponin-I değeri ile orta ve pH değeri ile zayıf ilişkili olduğu saptandı.Anahtar Sözcükler: Hipoksik-iskemik ensefalopati, mortalite, CK-MB, troponin-I, yenidoğan The evaluation of the relationships between the mortality and early period laboratory tests in the term infants diagnosed as hypoxic ischemic encephalopathy (HIE). Material and Methods:The newborns diagnosed as HIE between January 2004 and December 2008 were divided into two groups as the living and non-surviving groups. The two groups were evaluated prospectively.Results: Thirty two infants were included in the study. According to the Sarnat&Sarnat classification, 9 (28.1%), 14 (43.8%) and 9 infants (28.1%) were in stage 1, 2 and 3, respectively. Eight (25%) infants died. In the correlation evaluation of risk factors; lack of-follow-up at the antenatal period (r²=0.35) and having convulsions (r²=0.50) were positively associated with Sarnat stage. A positive relationship between Sarnat stage and the mortality rate was also determined (r²=0.57). CK-MB was strongly (r²=0.74), troponin-I moderately (r²=0.44), and pH weakly (r²=0.27) associated with mortality. In predicting mortality, the sensitivity and specificity for CK-MB was 100% and 91.6%, for Troponin I 100% and 70.8% and for pH 75% and 87.5%, respectively. Conclusion:This study demonstrates that in HIE, the relationship between the early period mortality rate and CK-MB values are strong, whereas for troponin-I and pH there is a moderate and weak association respectively.Key Words: Hypoxic-ischemic encephalopathy, mortality, CK-MB, troponin I, newborn : 28.01.2010: 28.01. Accepted: 07.05.2010 Giriş Hipoksik iskemik ensefalopati (HİE) intrapartum hipoksi veya geç antepartum serebral hipoksi ve iskeminin neden ol...

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“…Several hypotheses have been proposed. It could be that the perinatal period causes minimal myocardial compromise; alternatively, the rise may be a result of perinatal cardiovascular remodeling in the course of adapting to extrauterine life, possibly influenced by respiratory compromise (31,32). No relationship was found between elevated troponin levels and the method of delivery (33,34).…”

Section: Cardiac Troponinsmentioning

confidence: 98%

“…No relationship was found between elevated troponin levels and the method of delivery (33,34). Reference values are available, but, especially in the case of cTnI, these are related to the type of assay used (31). As discussed earlier, this is an important limitation for routine clinical use.…”

Section: Cardiac Troponinsmentioning

confidence: 99%