Cardiac biomarkers in premature calves with respiratory distress syndrome

Aydoğdu, Uğur; Yıldız, Ramazan; Güzelbekteş, Hasan; Coşkun, Alparslan; Şen, İsmai̇l

doi:10.1556/004.2016.004

Cited by 16 publications

(18 citation statements)

References 41 publications

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“…Therefore, all premature calves with RDS had mild metabolic and respiratory acidosis. Studies on premature calves (Ok and Birdane 2000, Yıldız 2014, Aydogdu and others 2016) showed that mixed acid-base disorders were common problem in premature calves with RDS. In premature calves with RDS, carbon dioxide increases in the blood because its elimination by lungs is impaired and this results in respiratory acidosis (Bleul and others 2007).…”

Section: Discussionmentioning

confidence: 99%

Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome

et al. 2017

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Hyperlactatemia, hypercapnia, low pH and low oxygen saturation (SatO) are commonly observed in premature calves. These clinical indicators are associated with increased mortality in preterm human newborns with respiratory distress syndrome (RDS). The aim of this study was to investigate the prognostic importance of venous pH, partial pressure of carbon dioxide (pCO) and lactate level and which parameters are related with mortality in premature calves with RDS. All premature calves (52 male/58 female) were admitted to clinic within 12-24 hours after birth and blood samples were also taken into heparinised plastic syringes from the jugular vein within 30 minutes following admission. Diagnosis of RDS was made by both clinical signs and blood gas results. For the evaluation of independent samples, t test was used to compare the venous blood gas indicators of surviving and non-surviving premature calves. Receiver operating characteristics curves were used to determine a cut-off value in terms of lactate and pCO measurements among non-surviving and surviving calves. Venous pH, pCO, SatO, base deficit, bicarbonate (HCO) and lactate levels showed a significant variance between surviving and non-surviving calves. Mean venous pH, pCO, SatO, lactate levels in non-surviving premature calves was 7.05, 78.9 mm Hg, 16.1 per cent and 9.50 mmol/l, respectively. Mean pH, pCO, SatO and lactate levels in surviving premature calves were 7.29, 56.3 mm Hg, 25.5 per cent and 5.1 mmol/l, respectively. The cut-off values for lactate and pCO were 7.5 mmol/l and 63.5 mm Hg, respectively. In conclusion, the results of the study show that venous blood lactate and pCO have prognostic importance in premature calves with RDS.

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Section: Discussionmentioning

confidence: 99%

Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome

et al. 2017

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“…The arterial blood pH, PaO 2 , PaCO 2 , base excess, lactate, glucose and oxygen saturation (SatO 2 ) were analysed using an automatic blood gas analyser (GEM Premier 3000, Inst. Laboratory, Lexington, USA) within 15 min after collection at 0 h (before treatment), Turkey)) and 5% dextrose (Dekstrosol, Vilsan, Turkey) were slowly infused to premature calves which, in PaCO 2 value measurements, were found to have pH values of less than 7.2 and base excess less than -3 mmol/l (Guzelbektes et al 2012;Aydogdu et al 2016). Fluids were administered only between the 2 nd and 10 th hour on the first day; only dextrose was administered on the second and third days to prevent changes in arterial blood gas values.…”

Section: Methodsmentioning

confidence: 99%

“…Veterinarni Medicina, 62, 2017(10): 541-552 doi: 10.17221/34/2017 hypoxaemia and the need to supplement oxygen (Kotecha 2000;Aydogdu et al 2016). It is thought that surfactant deficiency, poor development of the lung structure and fibrosis as a result of inflammation may play important roles in the development of respiratory distress syndrome in preterm human infants (Murch et al 1996;Lee et al 1998).…”

Section: Original Papermentioning

confidence: 99%

“…Premature calves suffer from life-threatening disorders associated with the incomplete development of organs including the brain, locomotor system, gastrointestinal tract and lungs (Bleul 2009;Altug and Basbugan 2013;Aydogdu et al 2016). The final stages in the development of normal lungs are interrupted by premature birth resulting in reduced gas exchange capacity due to decreased lung volumes and capillary surface areas.…”

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confidence: 99%

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Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Yıldız¹,

Ok²

2017

Vet. Med. - Czech

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Surfactant deficiency, poor development of the lung structure and fibrosis as a result of inflammation are thought to play an important role in the development of respiratory distress syndrome in premature calves. Nebulised steroid (fluticasone), bronchodilator (salbutamol) and diuretics (furosemide) can be used in combination alongside standard treatment procedures for premature calves, and might improve viability as observed in infants, foals and horses with pulmonary disorders. Twenty-five premature calves with respiratory distress syndrome were used in this study. Oxygen and supportive treatment were administered to all groups. The first group was used as a control group (Group 1). The nebulised drug combinations were as follows: Group 2: fluticasone + salbutamol, Group 3: salbutamol + furosemide, Group 4: fluticasone + furosemide and Group 5: fluticasone + salbutamol + furosemide. During the 72-h time period of the study, fluticasone (15 µg/kg/12 h), salbutamol (0.025 mg/kg/6 h) and furosemide (1 mg/kg/12h) were applied for 5 min. Arterial blood samples were collected from the auricular artery at 0 h and at 1, 24, 48 and 72 h for blood gas analysis. Significant (P < 0.05) increases in arterial partial oxygen, oxygen saturation and peripheral oxygen saturation and decreases in arterial partial carbon dioxide, lactate and respiration rate were observed in all the nebulised treatment groups, while a statistical difference was observed only for arterial partial carbon dioxide in control group. When comparing the treated groups with the control, it may be concluded that nebulised drugs are highly effective in the therapy of premature calves with respiratory distress syndrome, while the different nebulised groups exhibited similar efficacies.

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“…Premature birth interrupts prenatal organ maturation including the lungs, liver, cardiovascular system, kidneys, and the gastrointestinal tract (Sangild, ). Immaturity may impair the ability to cope with the disease in calves and predispose them to serious health problems (Aydogdu, Yildiz, Guzelbektes, Coskun, & Sen, ; Bittrich et al., ). Moreover, because of abnormal absorption associated with an immature intestine and the absence or weakness of the sucking reflex related to prematurity, premature calves could not take enough colostrum and immunoglobulin, which leads to a greater risk of developing infectious diarrhea, pneumonia, and sepsis than that in mature calves (Bleul, ; Weaver, Tyler, VanMetre, Hostetler, & Barrington, ; Yildiz & Ok, ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves

Çorum

Yıldız

İder

et al. 2019

Vet Pharm & Therapeutics

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The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome (CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) administrations in premature calves. Using a parallel design, 24 premature calves were randomly divided into the two antibiotic groups. Each of the six animals in the first group received CFQ (2 mg/kg) through IV or IM administration. The second group received CTX (20 mg/kg) via the same administration route. Plasma concentrations of the drugs were analyzed by high‐performance liquid chromatography and noncompartmental methods. Mean pharmacokinetic parameters of CFQ and CTX following IV administration were as follows: elimination half‐life (t1/2λz) 1.85 and 3.31 hr, area under the plasma concentration–time curve (AUC0–∞) 15.74 and 174 hr * μg/ml, volume of distribution at steady‐state 0.37 and 0.45 L/kg, and total body clearance 0.13 and 0.12 L hr−1 kg−1, respectively. Mean pharmacokinetic parameters of CFQ and CTX after IM injection were as follows: peak concentration 4.56 and 25.04 μg/ml, time to reach peak concentration 1 and 1.5 hr, t1/2λz 4.74 and 3.62 hr, and AUC0–∞ 22.75 and 147 hr * μg/ml, respectively. The bioavailability of CFQ and CTX after IM injection was 141% and 79%, respectively. IM administration of CFQ (2 mg/kg) and CTX (20 mg/kg) can be recommended at 12‐hr interval for treating infections caused by susceptible bacteria, with minimum inhibitory concentration values of ≤0.5 and ≤4 μg/ml, respectively, in premature calves. However, further research is indicated to assess the pharmacokinetic parameters following multiple doses of the drug in premature calves.

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Cardiac biomarkers in premature calves with respiratory distress syndrome

Cited by 16 publications

References 41 publications

Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome

Venous lactate, pH and partial pressure of carbon dioxide levels as prognostic indicators in 110 premature calves with respiratory distress syndrome

Clinical efficacy of combinations of nebulised fluticasone, salbutamol and furosemide on lung function in premature calves with respiratory distress syndrome

Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves

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