Comparison of Safety, Efficacy, Patient Compliance and Cost-Effectiveness of Transdermal, Oral and Intramuscular Diclofenac for Pain Control Following Oral Surgical Procedures

Samal, Dipti; Mishra, Niranjan; Meher, Brundabati; Kar, Indu Bhusan; Kar, Rosalin; Saipooja, R. H.

doi:10.1007/s12663-019-01260-7

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Therefore, it can be used for post-surgical and post-traumatic pain. More extensive clinical trials are needed to establish the scope of transdermal diclofenac in other oral surgical procedures [ 34 ].…”

Section: Reviewmentioning

confidence: 99%

Efficacy of Diclofenac Transdermal Patch in Therapeutic Extractions: A Literature Review

Awachat¹,

Shukla²,

Bhola³

2022

Cureus

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Diclofenac sodium is a nonsteroidal anti-inflammatory drug that effectively manages pain following therapeutic extractions. Post-extraction pain is commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs). In addition to their high bioavailability and long duration of action, transdermal NSAIDS have several other advantages. The review tries to understand and elucidate the use of transdermal patches, here Diclofenac, as a postoperative pain management modality. Drug delivery is one of the essential aspects of drug administration where transdermal patches are to be found equally effective when compared to oral administration of drugs. Various analgesics can be administered as patches, for example, ketoprofen, diclofenac, etc. There are also comparative studies between diclofenac and ketoprofen to see and understand the efficacy of transdermal patches compared with oral administration. Compared to oral administration, transdermal patches offer numerous benefits. These include avoidance of first-pass metabolism, sustained and non-rapid absorption, steady plasma levels that remain for prolonged periods, lack of patient dependence on drugs, prevention of gastric distress, and flexibility of stopping delivery of medications by simply removing the patch. This review aims to examine the diclofenac transdermal patch's effectiveness in reducing postoperative pain after orthodontic extraction.

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Section: Reviewmentioning

confidence: 99%

Efficacy of Diclofenac Transdermal Patch in Therapeutic Extractions: A Literature Review

Awachat¹,

Shukla²,

Bhola³

2022

Cureus

View full text Add to dashboard Cite

show abstract

Analgesics effect of local diclofenac in third molar surgery: a randomized, controlled trial

Siritham,

Powcharoen,

Wanichsaithong

et al. 2023

Clin Oral Invest

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A Review on Transdermal Patches Used as an Anti-Inflammatory Agent

CHOUDHURY¹,

Dutta²,

Kalita³

2021

Asian J Pharm Clin Res

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The transdermal drug delivery system is widely accepted due to its numerous advantages as it is a non-invasive drug administration process with prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance, and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs such as Diclofenac sodium, Lornoxicam, Aceclofenac, Ibuprofen, antihypertensive drugs, for example, Repaglinide, Atenolol, and Antiviral agents such as Stavudine, zidovudine represents the most commonly used medications for the treatment of pain and inflammatory reaction but various side effects can limit their use. Therefore, transdermal delivery of these drugs has advantages of avoiding hepatic first-pass effect, gastric irritation and delivering the drug for an extended period of time at a sustained level. The present article mainly focuses on the work been done on these drugs by formulated and delivered as transdermal patches to decrease the side effects related to the oral delivery.

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Comparison of Safety, Efficacy, Patient Compliance and Cost-Effectiveness of Transdermal, Oral and Intramuscular Diclofenac for Pain Control Following Oral Surgical Procedures

Cited by 3 publications

References 16 publications

Efficacy of Diclofenac Transdermal Patch in Therapeutic Extractions: A Literature Review

Efficacy of Diclofenac Transdermal Patch in Therapeutic Extractions: A Literature Review

Analgesics effect of local diclofenac in third molar surgery: a randomized, controlled trial

A Review on Transdermal Patches Used as an Anti-Inflammatory Agent

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